PDE4B as a microglia target to reduce neuroinflammation von Pearse, Damien D., Hughes, Zoë A.

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Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor von Möller, Thomas, Bard, Frédérique, Bhattacharya, Anindya, Biber, Knut, Campbell, Brian, Dale, Elena, Eder, Claudia, Gan, Li, Garden, Gwenn A., Hughes, Zoë A., Pearse, Damien D., Staal, Roland G. W., Sayed, Faten A., Wes, Paul D., Boddeke, Hendrikus W. G. M.

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Translational Pharmacology of PRAX‐944, a Novel T‐Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor von Scott, Liam, Puryear, Corey B., Belfort, Gabriel M., Raines, Shane, Hughes, Zoë A., Matthews, Lillian G., Ravina, Bernard, Wittmann, Marion

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The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers von Kahlig, Kristopher M., Scott, Liam, Hatch, Robert J., Griffin, Andrew, Martinez Botella, Gabriel, Hughes, Zoë A., Wittmann, Marion

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Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs von Tejeda, Hugo A, Hanks, Ashley N, Scott, Liam, Mejias-Aponte, Carlos, Hughes, Zoë A, O'Donnell, Patricio

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GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents von Klein, Adam K, Austin, Eric W, Cunningham, Michael J, Dvorak, Dino, Gatti, Silvia, Hulls, Sarah K, Kiss, Laszlo, Kruegel, Andrew C, Marek, Gerard J, Papp, Mariusz, Sporn, Jonathan, Hughes, Zoë A

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The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges von Graf, Radka, Longo, Jami L, Hughes, Zoë A

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The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation von Hedde, Joseph R, Hanks, Ashley N, Schmidt, Christopher J, Hughes, Zoë A

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The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise? von Sukoff Rizzo, Stacey J., Leonard, Sarah K., Gilbert, Adam, Dollings, Paul, Smith, Deborah L., Zhang, Mei-Yi, Di, Li, Platt, Brian J., Neal, Sarah, Dwyer, Jason M., Bender, Corey N., Zhang, Jean, Lock, Tim, Kowal, Dianne, Kramer, Angela, Randall, Andrew, Huselton, Christine, Vishwanathan, Karthick, Tse, Susanna Y., Butera, John, Ring, Robert H., Rosenzweig-Lipson, Sharon, Hughes, Zoë A., Dunlop, John

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First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B von Wakabayashi, Yuichi, Stenkrona, Per, Arakawa, Ryosuke, Yan, Xuefeng, Van Buskirk, Maia G, Jenkins, Madeline D, Santamaria, Jose A Montero, Maresca, Kevin P, Takano, Akihiro, Liow, Jeih-San, Chappie, Thomas A, Varrone, Andrea, Nag, Sangram, Zhang, Lei, Hughes, Zoë A, Schmidt, Christopher J, Doran, Shawn D, Mannes, Andrew, Zanotti-Fregonara, Paolo, Ooms, Maarten, Morse, Cheryl L, Zoghbi, Sami S, Halldin, Christer, Pike, Victor W, Innis, Robert B

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Pharmacological disruption of mouse social approach behavior: Relevance to negative symptoms of schizophrenia von Hanks, Ashley N., Dlugolenski, Keith, Hughes, Zoë A., Seymour, Patricia A., Majchrzak, Mark J.

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Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series von Griffin, Andrew M, Kahlig, Kristopher M, Hatch, Robert John, Hughes, Zoë A, Chapman, Mark L, Antonio, Brett, Marron, Brian E, Wittmann, Marion, Martinez-Botella, Gabriel

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Verbal working memory and functional large-scale networks in schizophrenia von Dauvermann, Maria R., Moorhead, Thomas WJ, Watson, Andrew R., Duff, Barbara, Romaniuk, Liana, Hall, Jeremy, Roberts, Neil, Lee, Graham L., Hughes, Zoë A., Brandon, Nicholas J., Whitcher, Brandon, Blackwood, Douglas HR, McIntosh, Andrew M., Lawrie, Stephen M.

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Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice von Baldan, Lissandra Castellan, Williams, Kyle A, Gallezot, Jean-Dominique, Pogorelov, Vladimir, Rapanelli, Maximiliano, Crowley, Michael, Anderson, George M, Loring, Erin, Gorczyca, Roxanne, Billingslea, Eileen, Wasylink, Suzanne, Panza, Kaitlyn E, Ercan-Sencicek, A Gulhan, Krusong, Kuakarun, Leventhal, Bennett L, Ohtsu, Hiroshi, Bloch, Michael H, Hughes, Zoë A, Krystal, John H, Mayes, Linda, de Araujo, Ivan, Ding, Yu-Shin, State, Matthew W, Pittenger, Christopher

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Differentiating antidepressants of the future: efficacy and safety von Rosenzweig-Lipson, Sharon, Beyer, Chad E, Hughes, Zoë A, Khawaja, Xavier, Rajarao, Somana J, Malberg, Jessica E, Rahman, Zia, Ring, Robert H, Schechter, Lee E

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The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortex von McTighe, Stephanie M, Neal, Sarah J, Lin, Qian, Hughes, Zoë A, Smith, Daniel G

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Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice von Castellan Baldan, Lissandra, Williams, Kyle A., Gallezot, Jean-Dominique, Pogorelov, Vladimir, Rapanelli, Maximiliano, Crowley, Michael, Anderson, George M., Loring, Erin, Gorczyca, Roxanne, Billingslea, Eileen, Wasylink, Suzanne, Panza, Kaitlyn E., Ercan-Sencicek, A. Gulhan, Krusong, Kuakarun, Leventhal, Bennett L., Ohtsu, Hiroshi, Bloch, Michael H., Hughes, Zoë A., Krystal, John H., Mayes, Linda, de Araujo, Ivan, Ding, Yu-Shin, State, Matthew W., Pittenger, Christopher

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WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent von Hughes, Zoë A., Liu, Feng, Platt, Brian J., Dwyer, Jason M., Pulicicchio, Claudine M., Zhang, Guoming, Schechter, Lee E., Rosenzweig-Lipson, Sharon, Day, Mark

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Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclizat... von Oliynyk, Markiyan, Stark, Christian B. W., Bhatt, Apoorva, Jones, Michelle A., Hughes‐Thomas, Zoë A., Wilkinson, Christopher, Oliynyk, Zoryana, Demydchuk, Yuliya, Staunton, James, Leadlay, Peter F.

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Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples von Zhang, Mei-Yi, Hughes, Zoë A., Kerns, Edward H., Lin, Qian, Beyer, Chad E.

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