Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons von Muroi, Yukiko, Ru, Fei, Kollarik, Marian, Canning, Brendan J., Hughes, Stephen A., Walsh, Stacey, Sigg, Martin, Carr, Michael J., Undem, Bradley J.

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Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs von Kamola, Piotr J., Maratou, Klio, Wilson, Paul A., Rush, Kay, Mullaney, Tanya, McKevitt, Tom, Evans, Paula, Ridings, Jim, Chowdhury, Probash, Roulois, Aude, Fairchild, Ann, McCawley, Sean, Cartwright, Karen, Gooderham, Nigel J., Gant, Timothy W., Moores, Kitty, Hughes, Stephen A., Edbrooke, Mark R., Clark, Kenneth, Parry, Joel D.

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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis von Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R

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In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization von Kamola, Piotr J, Kitson, Jeremy D A, Turner, Gemma, Maratou, Klio, Eriksson, Sofie, Panjwani, Aliza, Warnock, Linda C, Douillard Guilloux, Gaelle A, Moores, Kitty, Koppe, Emma L, Wixted, William E, Wilson, Paul A, Gooderham, Nigel J, Gant, Timothy W, Clark, Kenneth L, Hughes, Stephen A, Edbrooke, Mark R, Parry, Joel D

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Depletion of LAG‐3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781 von Ellis, Joanne, J.B. Marks, Daniel, Srinivasan, Naren, Barrett, Christine, Hopkins, Thomas G., Richards, Anna, Fuhr, Rainard, Albayaty, Muna, Coenen, Martin, Liefaard, Lia, Leavens, Karen, Nevin, Katherine L., Tang, Shuo, Hughes, Stephen A., Fortunato, Léa, Edwards, Ken, Cui, Yi, Anselm, Rabia, Delves, Christopher J., Charles, Emilie, Feeney, Maria, Webb, Thomas M., Brett, Sara J., Schmidt, Tim S., Stone, John, Savage, Caroline O.S., Wisniacki, Nicolas, Tarzi, Ruth M.

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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains von Chung, Chun-wa, Coste, Hervé, White, Julia H, Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L, Delves, Chris, Magny, Sylvie M, Woodward, Robert, Hughes, Stephen A, Boursier, Eric V, Flynn, Helen, Bouillot, Anne M, Bamborough, Paul, Brusq, Jean-Marie G, Gellibert, Françoise J, Jones, Emma J, Riou, Alizon M, Homes, Paul, Martin, Sandrine L, Uings, Iain J, Toum, Jérôme, Clément, Catherine A, Boullay, Anne-Bénédicte, Grimley, Rachel L, Blandel, Florence M, Prinjha, Rab K, Lee, Kevin, Kirilovsky, Jorge, Nicodeme, Edwige

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Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, ran... von Aley, Parvinder K, Harndahl, Linda, Haughney, John, Hicks, Alexander, Lambe, Teresa, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Pan, Daniel, Regan, Karen, Saich, Stephen, Salkeld, Jo, Sheridan, Ray, Sturdy, Ann, Todd, Shirley, Read, Robert C, Nguyen-Van-Tam, Jonathan S, Rogers, Chris A, Longshaw, Laura, Reeder, Sally, Storton, Kim, Tandy, Bridget, Cox, Stephen, Shenoy, Anil, Calderwood, James, Thorp, Helen, Evans, Julie, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Makia, Fiona, Hopkins, NinaSimone, khan, Farida, Adebambo, Olumide, Chita, Sunder, Mazzella, Andrea, Jackson, Beth, Broadhead, Samantha, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Lyon, Rebecca, Cole, Christine, Beckett, Helen, Brown, Claire, Trinham, Charlotte, Hurdover, Steve, Ferreira Da Silva, Carla, White, Rachel, Morshead, Gertraud, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Minnis, Christine, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Shaik, Imam, Allen, Lauren, Thomas, Steve, Perkins, Jonathan, Gowland, Andrew, Peters, Erica, James, Rob, Seath, Ingrid, Newman, Joseph, Boubriak, Iryna, Bell, Judith, Coughlan, Tricia, Ronan, Nicholas, Dare, Tracey, Ricamara, Marivic, Roy, Subarna, Ambihapathy, Wythehi, Spencer, Joanne, Warren, Sarah, Haskell, Louise, Romani, Rossana, Bentley, Ian, Watson, Tara, Nightingale, Kari, Lingwood, Aidan, Chalwin, Olivia, Burton, Holly, Welham, Benjamin, Branney, Debbie, Wiselka, Martin, Vail, Dennyl, Lewis-Taylor, Jessica, Magan, Javier, Appleby, Kim

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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia von Davis, John B, Gray, Julie, Gunthorpe, Martin J, Hatcher, Jonathan P, Davey, Phil T, Overend, Philip, Harries, Mark H, Latcham, Judi, Clapham, Colin, Atkinson, Kirsty, Hughes, Stephen A, Rance, Kim, Grau, Evelyn, Harper, Alex J, Pugh, Perdita L, Rogers, Derek C, Bingham, Sharon, Randall, Andrew, Sheardown, Steven A

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Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans von Tuijnenburg, Paul, Jansen, Machiel H., Carss, Keren J., Baxendale, Helen, Chandra, Anita, Seneviratne, Suranjith L., Oksenhendler, Eric, Tool, Anton T.J., Whitehorn, Deborah, Turro, Ernest, Thaventhiran, James E., Kuijpers, Taco W., Adhya, Zoe, Anantharachagan, Ariharan, Arumugakani, Gururaj, Bacchelli, Chiara, Baxendale, Helen, Bibi, Shahnaz, Booth, Claire, Browning, Michael, Burns, Siobhan, Clifford, Hayley, Cooper, Nichola, Davies, Sophie, Devlin, Lisa, Edgar, David, Egner, William, Ghurye, Rohit, Gilmour, Kimberley, Goddard, Sarah, Gordins, Pavel, Hackett, Scott, Hague, Rosie, Hayman, Grant, Jolles, Stephen, Jones, Julie, Kelleher, Peter, Klein, Nigel, Kuijpers, Taco, Kumararatne, Dinakantha, Laffan, James, Lango Allen, Hana, Lear, Sara, Longhurst, Hilary, Maimaris, Jesmeen, McDermott, Elizabeth, Morrisson, Valerie, Nasir, Iman, Noorani, Sadia, Oksenhendler, Eric, Ponsford, Mark, Qasim, Waseem, Quinn, Ellen, Quinti, Isabella, Samarghitean, Crina, Savic, Sinisa, Seneviratne, Suranjith, Simeoni, Ilenia, Staples, Emily, Steele, Cathal, Thaventhiran, James, Thomas, Moira, Thrasher, Adrian, Worth, Austen, Yong, Patrick, Bradley, John, Hammerton, Tracey, Ouwehand, Willem, Raymond, F Lucy, Veltman, Marijke, Clements-Brod, Naomi, Davis, John, Dewhurst, Eleanor, Erwood, Marie, Frary, Amy, Linger, Rachel, Papadia, Sofia, Rehnstrom, Karola, Astle, William, Attwood, Antony, Bleda, Marta, Carss, Keren, Daugherty, Louise, Deevi, Sri, Graf, Stefan, Greene, Daniel, Halmagyi, Csaba, Matser, Vera, Meacham, Stuart, Megy, Karyn, Shamardina, Olga, Titterton, Catherine, Tuna, Salih, Turro, Ernest, von Ziegenweldt, Julie, Furnell, Abigail, Staines, Simon, Stephens, Jonathan, Whitehorn, Deborah, Watt, Christopher

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Safety of live attenuated influenza vaccine in atopic children with egg allergy von Turner, Paul J., FRACP, PhD, Southern, Jo, PhD, Andrews, Nick J., PhD, Miller, Elizabeth, FRCPath, Erlewyn-Lajeunesse, Michel, DM

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Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations von Lorenzini, Tiziana, Fliegauf, Manfred, Klammer, Nils, Proietti, Michele, Bulashevska, Alla, Schejter, Yael D., Atschekzei, Faranaz, Stepensky, Polina, Pedroza, Luis A., van der Flier, Michiel, Martínez-Gallo, Mónica, Svec, Peter, Fischer, Ute, Ip, Winnie, Geha, Raif, Chou, Janet, Alosaimi, Mohammed, Weintraub, Lauren, Dos Santos Vilela, Maria Marluce, Holzinger, Dirk, Seidl, Maximilian, Lougaris, Vassilios, Plebani, Alessandro, Abolhassani, Hassan, Thaventhiran, James E., Warnatz, Klaus, Grimbacher, Bodo, Ashford, Sofie, Bacchelli, Chiara, Batista, Joana, Bibi, Shahnaz, Boardman, Barbara, Booth, Claire, Breen, Gerome, Burns, Siobhan O., Burren, Oliver S., Carss, Keren, Chambers, John, Cooper, Nichola, Davies, E.G., Dempster, John, Dewhurst, Eleanor F., Drewe, Elizabeth, Duarte, Daniel, Edgar, J. David M., Egner, William, El-Shanawany, Tariq, Erwood, Marie, Fox, James, Frontini, Mattia, Furnell, Abigail, Gaspar, H. Bobby, Gleadall, Nicholas S., Grigoriadou, Sofia, Hackett, Scott, Hague, Rosie, Haimel, Matthias, Hayman, Grant, Hu, Fengyuan, Huissoon, Aarnoud P., Jolles, Stephen, Kasanicki, Mary A., Kelleher, Peter, Klein, Nigel, Kreuzhuber, Roman, Kuijpers, Taco W., Kumararatne, Dinakantha, Allen, Hana Lango, Linger, Rachel, Lorenzo, Lorena E., Maimaris, Jesmeen, Martin, Jennifer, McDermott, Elizabeth M., Meacham, Stuart, Morrisson, Valerie, Nasir, Iman, Nejentsev, Sergey, Papadia, Sofia, Ponsford, Mark J., Quinn, Ellen, Quinti, Isabella, Rayner-Matthews, Paula J., Samani, Nilesh, Sanchis-Juan, Alba, Savic, Sinisa, Simpson, Michael A., Smith, Kenneth G.C., Thaventhiran, James E., Tilly, Tobias, Titterton, Catherine, Tuna, Salih, Urniaz, Rafal, von Ziegenweidt, Julie, Watt, Christopher, Welch, Steven B., Whitehorn, Deborah, Wood, Yvette, Workman, Sarita, Worth, Austen, Young, Timothy

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Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma von Turner, Paul J., Fleming, Louise, Saglani, Sejal, Southern, Jo, Andrews, Nick J., Miller, Elizabeth, Adams, Alexandra, Doyle, Christine, Erlewyn-Lajeunesse, Michel, Fidler, Katy, Fleming, Louise, Gupta, Atul, Hughes, Stephen M., Ives, Andrew, Jay, Nicola, Kansra, Sonal, Michaelis, Louise, Moss, Samantha, Murray, Clare, Nagakumar, Prasad, Roberts, Graham, Saglani, Sejal, Seddon, Paul, Sinha, Ian, Stiefel, Gary, Thomas, Huw M., Turner, Paul J.

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‘Be on the TEAM’ Study (Teenagers Against Meningitis): protocol for a controlled clinical trial evaluating the impact of 4CMenB or MenB-fHbp vaccination on the pharyngeal carriage... von Carr, Jeremy, Plested, Emma, Aley, Parvinder, Camara, Susana, Davis, Kimberly, MacLennan, Jenny M, Gray, Steve, Faust, Saul N, Borrow, Ray, Christensen, Hannah, Trotter, Caroline, Maiden, Martin C J, Finn, Adam, Snape, Matthew D

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Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus standard care von Orton, Christopher M, Grinsztejn, Beatriz, Donaldson, Gavin C, Crabtree Ramírez, Brenda, Tonkin, James, Cardoso, Sandra W, Ritchie, Andrew I, Conway, Francesca, Riberio, Maria P D, Wiseman, Dexter J, Vijayakumar, Bavithra, Leaper, Craig, Mann, Bobby, Samson, Anda, Bhavsar, Pankaj K, Boffito, Marta, Johnson, Mark R, Pelly, Michael, Foster, Damon, Shabbir, Nadia, Connolly, Simon, Winpenny, Carmen, Daby, Doris, Pepper, Samuel, Carungcong, Jamie, Fedele, Serge, Samson-Fessale, Pardina, Schoolmeesters, Alexandra, Gomes de Almeida Martins, Laura, Bull, Rhian, Correia Da Costa, Patricia, Bautista, Carina, Eleanor Flores, Maria, Macabodbod, Lester, Houseman, Rosalie, Svensson, Marie-Louise, Sayan, Amrinder, Fung, Carrie, Garner, Justin, Lai, Dilys, Nelson, Mark, Moore, Luke, Davies, Gary, Ouma, Beatrice, Salinos, Clovis, Salha, Jad, Yassein, Redasaad, Abbasi, Abdul, Thankachen, Mini, Barker, Amy, Fernandes, Candida, Beatriz, Veronica, Flores, Leah, Rocca, Alessandra, Martella, Carmela, Lloyd, Charlotte, Nolan, Ciara, Horsford, Latoya, Martins, Laura, Thomas, Lervina, Winstanley, Mark, Bourke, Miriam, Branch, Nicholas, Orhan, Orhan, Saunder, Sangeetha, Patil, Shashank, Hughes, Stephen, Zhe, Wu, De Leon, Ashley, Farah, Ayaan, Rya, Grace, Alizadeh, Katrin, Leong, Kirsty, Trepte, Laure, Goel, Nupur, McGown, Patrick, Kirwan, Ursula, Vilela Baião, Tamiris, Marins, Luana, Nazer, Sandro, Malaguthi de Souza, Raquel, Feitosa, Marcella, Lessa, Flavia, Silva de Magalhães, Elizabeth, Costenaro, Jamile, de Cassia Alves Lira, Rita, Carolina, Ana, Machado Da Silva, Andre, Kliemann, Dimas, De Cassia Alves Lira, Rita, Walker, Gemma, Lowthorpe, Vicki, Lillie, Patrick, Easom, Nicholas, Sierra Madero, Juan, López Iñiguez, Álvaro, Paola Alarcón Murra, Claudia, Alanis Vega, Audelia, Muñoz Trejo, Teresa, Pérez Rodríguez, Olivia

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Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma von Minskaia, Ekaterina, Maimaris, Jesmeen, Jenkins, Persephone, Albuquerque, Adriana S., Hong, Ying, Eleftheriou, Despina, Gilmour, Kimberly C., Grace, Richard, Moreira, Fernando, Grimbacher, Bodo, Morris, Emma C., Burns, Siobhan O.

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Safety of live attenuated influenza vaccine in young people with egg allergy: multicentre prospective cohort study von Turner, Paul J, Southern, Jo, Andrews, Nick J, Miller, Elizabeth, Erlewyn-Lajeunesse, Michel

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A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT) von Murray, David W, MacLennan, Graeme S, Breeman, Suzanne, Dakin, Helen A, Johnston, Linda, Campbell, Marion K, Gray, Alastair M, Fiddian, Nick, Fitzpatrick, Ray, Morris, Richard W, Grant, Adrian M

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Practical challenges for functional validation of STAT1 gain of function genetic variants von Albuquerque, Adriana S, Maimaris, Jesmeen, McKenna, Alexander J, Lambourne, Jonathan, Moreira, Fernando, Workman, Sarita, Megy, Karyn, Simeoni, Ilenia, Lango Allen, Hana, Morris, Emma C, Burns, Siobhan O

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Prevention of vaccine-matched and mismatched influenza in children aged 6–35 months: a multinational randomised trial across five influenza seasons von Claeys, Carine, Zaman, Khalequ, Dbaibo, Ghassan, Li, Ping, Izu, Allen, Kosalaraksa, Pope, Acosta, Beatriz, Arroba Basanta, Maria Luisa, Aziz, Asma, Cabanero, Miguel Angel, Chandrashekaran, Vijayalakshmi, Corsaro, Bartholomew, Cousin, Luis, Diaz, Adolfo, Friel, Damien, Garcia-Sicilia, Jose, Gomez-Go, Grace D, Antoinette Gonzales, Maria Liza, Hughes, Stephen M, Jackowska, Teresa, Kant, Shashi, Malvaux, Ludovic, Mares Bermudez, Josep, Martinon-Torres, Federico, Miranda, Mariano, Montellano, May, Prymula, Roman, Puthanakit, Thanyawee, Ruzkova, Renata, Sadowska-Krawczenko, Iwona, Salamanca de la Cueva, Ignacio, Sokal, Etienne, Soni, Jyoti, Szymanski, Henryk, Ulied, Angels, Schuind, Anne, Jain, Varsha K, Innis, Bruce L, Acostas, Beatriz, Amanullah, Arshad, Ariza, Miguel, Arroba Basanta, Maria Luisa, Aziz, Asma, Bautista, Milagros, Bodalia, Bhavesh, Bravo, Lulu C, Brzostek, Jerzy, Cabanero, Miguel Angel, Caldwell, Ian, Carmona, Alfonso, Chandrashekaran, Vijayalakshmi, Claeys, Carine, Corsaro, Bartholomew, Cousin, Luis, Danier, Jasur, Dbaibo, Ghassan, Diaz Cirujano, Ana Isabel, Diaz, Adolfo, Diez-Domingo, Javier, Dinleyici, Ener Cagri, Docx, Martine, Faust, Saul N, Galaj, Andrzej, Garcia Rodriguez, Fermin, Garcia-Sicilia, Jose, Gonzales, Maria Liza Antoinette, Gomez-Go, Grace D, Gooding, Trevor, Hacimustafaoglu, Mustafa, Heath, Paul, Heaton, Paul, Innis, Bruce L, Izu, Allen, Jackowska, Teresa, Jain, Varsha K, Kant, Shashi, Kosalaraksa, Pope, Lalwani, Sanjay, Li, Ping, Logghe, Karl, Malvaux, Ludovic, Mantyka, Jolanta, Mares Bermudez, Josep, McNally, Damien, Montellano, May, Prymula, Roman, Puthanakit, Thanyawee, Ruzkova, Renata, Sablan, Benjamin, Sadowska-Krawczenko, Iwona, Salamanca de la Cueva, Ignacio, Schuind, Anne, Snape, Matthew, Soni, Jyoti, Tomlinson, Richard, Ulied, Angels, Verghote, Marc, Vertruyen, Andre, Wheeler, Marie, Zaman, Khalequ

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Examining the Impact of Patient Characteristics and Symptomatology on Knowledge, Attitudes, and Beliefs Among Foreign-born Tuberculosis Cases in the US and Canada von Colson, Paul W., Couzens, G. Lance, Royce, Rachel A., Kline, Tracy, Chavez-Lindell, Tamara, Welbel, Sharon, Pang, Jenny, Davidow, Amy, Hirsch-Moverman, Yael

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