Structure‐Based Design of a Macrocyclic PROTAC von Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual... von Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation von Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

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SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate von Roy, Michael J, Winkler, Sandra, Hughes, Scott J, Whitworth, Claire, Galant, Michael, Farnaby, William, Rumpel, Klaus, Ciulli, Alessio

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The rise and rise of protein degradation: Opportunities and challenges ahead von Hughes, Scott J., Testa, Andrea, Thompson, Nicola, Churcher, Ian

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Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 von Hughes, Scott J., Cravetchi, Xenia, Vilas, Gonzalo, Hammond, James R.

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Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs von Hughes, Scott J, Antoshchenko, Tetyana, Chen, Yun, Lu, Hua, Pizarro, Juan C, Park, Hee-Won

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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders von Hanzl, Alexander, Casement, Ryan, Imrichova, Hana, Hughes, Scott J., Barone, Eleonora, Testa, Andrea, Bauer, Sophie, Wright, Jane, Brand, Matthias, Ciulli, Alessio, Winter, Georg E.

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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity von Imaide, Satomi, Riching, Kristin M., Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J., Trainor, Nicole, Mahan, Sarah D., Murphy, Nancy, Cowan, Angus D., Chan, Kwok-Ho, Craigon, Conner, Testa, Andrea, Maniaci, Chiara, Urh, Marjeta, Daniels, Danette L., Ciulli, Alessio

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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs von Klein, Victoria G, Townsend, Chad E, Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J, Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott

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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs von Girardini, Miriam, Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Ciulli, Alessio

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Correction: Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs von Hughes, Scott J, Antoshchenko, Tetyana, Chen, Yun, Lu, Hua, Pizarro, Juan C, Park, Hee-Won

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Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus von Hughes, Scott J., Antoshchenko, Tetyana, Kim, Kyung Phil, Smil, David, Park, Hee-Won

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Structure‐Based Design of a Macrocyclic PROTAC von Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio

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Identification of cysteines involved in the effects of methanethiosulfonate reagents on human equilibrative nucleoside transporter 1 von Park, Jamie S, Hughes, Scott J, Cunningham, Frances K M, Hammond, James R

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Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product von Hughes, Scott J, Barnard, Leanne, Mottaghi, Katayoun, Tempel, Wolfram, Antoshchenko, Tetyana, Hong, Bum Soo, Allali-Hassani, Abdellah, Smil, David, Vedadi, Masoud, Strauss, Erick, Park, Hee-Won

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Probing the ATP site of GRP78 with nucleotide triphosphate analogs von Hughes, Scott J., Antoshchenko, Tetyana, Chen, Yun, Lu, Hua, Pizarro, Juan C., Park, Hee -Won

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Translating PROTAC chemical series optimization into functional outcomes underlying BRD7 and BRD9 protein degradation von Riching, Kristin M., Vasta, James D., Hughes, Scott J., Zoppi, Vittoria, Maniaci, Chiara, Testa, Andrea, Urh, Marjeta, Ciulli, Alessio, Daniels, Danette L.

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SMALL MOLECULES von CIULLI, Alessio, HUGHES, Scott J, TESTA, Andrea, MANIACI, Chiara

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SMALL MOLECULES von Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Hughes, Scott J

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