Identification and characterization of essential genes in the human genome von Wang, Tim, Birsoy, Kivanç, Hughes, Nicholas W., Krupczak, Kevin M., Post, Yorick, Wei, Jenny J., Lander, Eric S., Sabatini, David M.

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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth von Tang, Rui, Shuldiner, Emily G., Kelly, Marcus, Murray, Christopher W., Hebert, Jess D., Andrejka, Laura, Tsai, Min K., Hughes, Nicholas W., Parker, Mitchell I., Cai, Hongchen, Li, Yao-Cheng, Wahl, Geoffrey M., Dunbrack, Roland L., Jackson, Peter K., Petrov, Dmitri A., Winslow, Monte M.

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Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras von Wang, Tim, Yu, Haiyan, Hughes, Nicholas W., Liu, Bingxu, Kendirli, Arek, Klein, Klara, Chen, Walter W., Lander, Eric S., Sabatini, David M.

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dCas9-based gene editing for cleavage-free genomic knock-in of long sequences von Wang, Chengkun, Qu, Yuanhao, Cheng, Jason K. W., Hughes, Nicholas W., Zhang, Qianhe, Wang, Mengdi, Cong, Le

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CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells von Wang, Chengkun, Xia, Qiong, Zhang, Qianhe, Qu, Yuanhao, Su, Stephen, Cheng, Jason K W, Hughes, Nicholas W, Cong, Le

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Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles von Hughes, Nicholas W., Qu, Yuanhao, Zhang, Jiaqi, Tang, Weijing, Pierce, Justin, Wang, Chengkun, Agrawal, Aditi, Morri, Maurizio, Neff, Norma, Winslow, Monte M., Wang, Mengdi, Cong, Le

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Microbial single-strand annealing proteins enable CRISPR gene-editing tools with improved knock-in efficiencies and reduced off-target effects von Wang, Chengkun, Cheng, Jason K W, Zhang, Qianhe, Hughes, Nicholas W, Xia, Qiong, Winslow, Monte M, Cong, Le

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Computationally guided high-throughput engineering of an anti-CRISPR protein for precise genome editing in human cells von Marsiglia, Julia, Vaalavirta, Kia, Knight, Estefany, Nakamura, Muneaki, Cong, Le, Hughes, Nicholas W.

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A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer von Cai, Hongchen, Chew, Su Kit, Li, Chuan, Tsai, Min K, Andrejka, Laura, Murray, Christopher W, Hughes, Nicholas W, Shuldiner, Emily G, Ashkin, Emily L, Tang, Rui, Hung, King L, Chen, Leo C, Lee, Shi Ya C, Yousefi, Maryam, Lin, Wen-Yang, Kunder, Christian A, Cong, Le, McFarland, Christopher D, Petrov, Dmitri A, Swanton, Charles, Winslow, Monte M

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Multiplexed screens identify RAS paralogs HRAS and NRAS as suppressors of KRAS-driven lung cancer growth von Tang, Rui, Shuldiner, Emily G., Kelly, Marcus, Murray, Christopher W., Hebert, Jess D., Andrejka, Laura, Tsai, Min K., Hughes, Nicholas W., Parker, Mitchell I, Cai, Hongchen, Li, Yao-Cheng, Wahl, Geoffrey M., Dunbrack, Roland L, Jackson, Peter K., Petrov, Dmitri A., Winslow, Monte M.

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Abstract 827: A journey to deconvolute the multifaceted functions and context-dependency of cancer driver genes von Cai, Hongchen, Chew, Su Kit, Li, Chuan, Murray, Christopher W., Andrejka, Laura, Hebert, Jess D., Tsai, Min K., Tang, Rui, Hughes, Nicholas W., Shuldiner, Emily G., Ashkin, Emily L., Lee, Shi Ya C., Yousefi, Maryam, Petrov, Dmitri A., Swanton, Charles, Winslow, Monte W.

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COMPRESSIVE MOLECULAR PROBES FOR GENOMIC EDITING AND TRACKING von Cong, Le, Hughes, Nicholas W

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COMPRESSIVE MOLECULAR PROBES FOR GENOMIC EDITING AND TRACKING von CONG, Le, HUGHES, Nicholas W

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Collectively Encoded Rydberg Qubit von Spong, Nicholas L. R., Jiao, Yuechun, Hughes, Oliver D. W., Weatherill, Kevin J., Lesanovsky, Igor, Adams, Charles S.

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Horizontally acquired glycosyltransferase operons drive salmonellae lipopolysaccharide diversity von Davies, Mark R, Broadbent, Sarah E, Harris, Simon R, Thomson, Nicholas R, van der Woude, Marjan W

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The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 von Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.

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Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial von Murphy, Patrick B, Rehal, Sunita, Arbane, Gill, Bourke, Stephen, Calverley, Peter M. A, Crook, Angela M, Dowson, Lee, Duffy, Nicholas, Gibson, G. John, Hughes, Philip D, Hurst, John R, Lewis, Keir E, Mukherjee, Rahul, Nickol, Annabel, Oscroft, Nicholas, Patout, Maxime, Pepperell, Justin, Smith, Ian, Stradling, John R, Wedzicha, Jadwiga A, Polkey, Michael I, Elliott, Mark W, Hart, Nicholas

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Gut microbiota composition is associated with environmental landscape in honey bees von Jones, Julia C, Fruciano, Carmelo, Hildebrand, Falk, Al Toufalilia, Hasan, Balfour, Nicholas J, Bork, Peer, Engel, Philipp, Ratnieks, Francis LW, Hughes, William OH

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Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma von Merchant, Thomas E, Bendel, Anne E, Sabin, Noah D, Burger, Peter C, Shaw, Dennis W, Chang, Eric, Wu, Shengjie, Zhou, Tianni, Eisenstat, David D, Foreman, Nicholas K, Fuller, Christine E, Anderson, Edwina Templeton, Hukin, Juliette, Lau, Ching C, Pollack, Ian F, Laningham, Fred H, Lustig, Robert H, Armstrong, Floyd D, Handler, Michael H, Williams-Hughes, Chris, Kessel, Sandra, Kocak, Mehmet, Ellison, David W, Ramaswamy, Vijay

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Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments von Yu, Jong W, Bhattacharya, Sabyasachi, Yanamandra, Niranjan, Kilian, David, Shi, Hong, Yadavilli, Sapna, Katlinskaya, Yuliya, Kaczynski, Heather, Conner, Michael, Benson, William, Hahn, Ashleigh, Seestaller-Wehr, Laura, Bi, Meixia, Vitali, Nicholas J, Tsvetkov, Lyuben, Halsey, Wendy, Hughes, Ashley, Traini, Christopher, Zhou, Hui, Jing, Junping, Lee, Tae, Figueroa, David J, Brett, Sara, Hopson, Christopher B, Smothers, James F, Hoos, Axel, Srinivasan, Roopa

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