Fibrin activates GPVI in human and mouse platelets von Alshehri, Osama M., Hughes, Craig E., Montague, Samantha, Watson, Stephanie K., Frampton, Jon, Bender, Markus, Watson, Steve P.

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Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring von Gaspar, Renato S., Unsworth, Amanda J., Al-Dibouni, Alaa, Bye, Alexander P., Sage, Tanya, Stewart, Michelle, Wells, Sara, Cox, Roger D., Gibbins, Jonathan M., Sellayah, Dyan, E. Hughes, Craig

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Immobilized fibrinogen activates human platelets through glycoprotein VI von Mangin, Pierre H, Onselaer, Marie-Blanche, Receveur, Nicolas, Le Lay, Nicolas, Hardy, Alexander T, Wilson, Clare, Sanchez, Ximena, Loyau, Stéphane, Dupuis, Arnaud, Babar, Amir K, Miller, Jeanette Lc, Philippou, Helen, Hughes, Craig E, Herr, Andrew B, Ariëns, Robert As, Mezzano, Diego, Jandrot-Perrus, Martine, Gachet, Christian, Watson, Steve P

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Low-dose Btk inhibitors selectively block platelet activation by CLEC-2 von Nicolson, Phillip L R, Nock, Sophie H, Hinds, Joshua, Garcia-Quintanilla, Lourdes, Smith, Christopher W, Campos, Joana, Brill, Alexander, Pike, Jeremy A, Khan, Abdullah O, Poulter, Natalie S, Kavanagh, Diedre M, Watson, Stephanie, Watson, Callum N, Clifford, Hayley, Huissoon, Aarnoud P, Pollitt, Alice Y, Eble, Johannes A, Pratt, Guy, Watson, Steve P, Hughes, Craig E

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Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI von Nicolson, Phillip L R, Hughes, Craig E, Watson, Stephanie, Nock, Sophie H, Hardy, Alexander T, Watson, Callum N, Montague, Samantha J, Clifford, Hayley, Huissoon, Aarnoud P, Malcor, Jean-Daniel, Thomas, Mark R, Pollitt, Alice Y, Tomlinson, Michael G, Pratt, Guy, Watson, Steve P

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Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells von Pollitt, Alice Y., Poulter, Natalie S., Gitz, Eelo, Navarro-Nuñez, Leyre, Wang, Ying-Jie, Hughes, Craig E., Thomas, Steven G., Nieswandt, Bernhard, Douglas, Michael R., Owen, Dylan M., Jackson, David G., Dustin, Michael L., Watson, Steve P.

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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development von Finney, Brenda A., Schweighoffer, Edina, Navarro-Núñez, Leyre, Bénézech, Cecile, Barone, Francesca, Hughes, Craig E., Langan, Stacey A., Lowe, Kate L., Pollitt, Alice Y., Mourao-Sa, Diego, Sheardown, Steve, Nash, Gerard B., Smithers, Nicholas, Reis e Sousa, Caetano, Tybulewicz, Victor L.J., Watson, Steve P.

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CLEC-2 activates Syk through dimerization von Hughes, Craig E., Pollitt, Alice Y., Mori, Jun, Eble, Johannes A., Tomlinson, Michael G., Hartwig, John H., O'Callaghan, Christopher A., Fütterer, Klaus, Watson, Steve P.

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Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib von Bye, Alexander P., Unsworth, Amanda J., Desborough, Michael J., Hildyard, Catherine A.T., Appleby, Niamh, Bruce, David, Kriek, Neline, Nock, Sophie H., Sage, Tanya, Hughes, Craig E., Gibbins, Jonathan M.

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Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands von Alshehri, Osama M, Montague, Samantha, Watson, Stephanie, Carter, Paul, Sarker, Najiat, Manne, Bhanu K, Miller, Jeanette L C, Herr, Andrew B, Pollitt, Alice Y, O'Callaghan, Chris A, Kunapuli, Satya, Arman, Mònica, Hughes, Craig E, Watson, Steve P

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G6f-like is an ITAM-containing collagen receptor in thrombocytes von Hughes, Craig E, Radhakrishnan, Uvaraj P, Lordkipanidzé, Marie, Egginton, Stuart, Dijkstra, Johannes M, Jagadeeswaran, Pudur, Watson, Stephen P

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A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: Involvement of G6f, a novel platelet Grb2-binding membrane adapter von García, Ángel, Senis, Yotis A., Antrobus, Robin, Hughes, Craig E., Dwek, Raymond A., Watson, Steve P., Zitzmann, Nicole

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The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets von Hughes, Craig E., Finney, Brenda A., Koentgen, Frank, Lowe, Kate L., Watson, Steve P.

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Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2) von Manne, Bhanu Kanth, Getz, Todd M., Hughes, Craig E., Alshehri, Osama, Dangelmaier, Carol, Naik, Ulhas P., Watson, Steve P., Kunapuli, Satya P.

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Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin R... von Hughes, Craig E., Sinha, Uma, Pandey, Anjali, Eble, Johannes A., O'Callaghan, Christopher A., Watson, Steve P.

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CLEC‐2 is not required for platelet aggregation at arteriolar shear von HUGHES, C. E., NAVARRO‐NÚÑEZ, L., FINNEY, B. A., MOURÃO‐SÁ, D., POLLITT, A. Y., WATSON, S. P.

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SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice von Cherpokova, Deya, Bender, Markus, Morowski, Martina, Kraft, Peter, Schuhmann, Michael K., Akbar, Sarah M., Sultan, Cheryl S., Hughes, Craig E., Kleinschnitz, Christoph, Stoll, Guido, Dragone, Leonard L., Watson, Steve P., Tomlinson, Michael G., Nieswandt, Bernhard

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Growth Factor Receptor–Bound Protein 2 Contributes to (Hem)Immunoreceptor Tyrosine-Based Activation Motif–Mediated Signaling in Platelets von Dütting, Sebastian, Vögtle, Timo, Morowski, Martina, Schiessl, Sarah, Schäfer, Carmen M, Watson, Stephanie K, Hughes, Craig E, Ackermann, Jochen A, Radtke, Daniel, Hermanns, Heike M, Watson, Steve P, Nitschke, Lars, Nieswandt, Bernhard

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Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets von Pears, Catherine J., Thornber, Kelly, Auger, Jocelyn M., Hughes, Craig E., Grygielska, Beata, Protty, Majd B., Pearce, Andrew C., Watson, Steve P.

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Involvement of Src kinases and PLCγ2 in clot retraction von Suzuki-Inoue, Katsue, Hughes, Craig E, Inoue, Osamu, Kaneko, Makoto, Cuyun-Lira, Olga, Takafuta, Toshiro, Watson, Steve P, Ozaki, Yukio

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