Murine bone-derived mesenchymal stem cells undergo molecular changes after a single passage in culture von Hughes, Anastasia M., Kuek, Vincent, Oommen, Joyce, Kotecha, Rishi S., Cheung, Laurence C.

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Therapeutic Targeting of the Leukaemia Microenvironment von Kuek, Vincent, Hughes, Anastasia M., Kotecha, Rishi S., Cheung, Laurence C.

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Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia von Hughes, Anastasia M, Kuek, Vincent, Oommen, Joyce, Chua, Grace-Alyssa, van Loenhout, Maria, Malinge, Sebastien, Kotecha, Rishi S, Cheung, Laurence C

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Romidepsin enhances the efficacy of cytarabine in vivo , revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A -rearranged infant acute lymphoblast... von Cheung, Laurence C, Cruickshank, Mark N, Hughes, Anastasia M, Singh, Sajla, Chua, Grace-Alyssa, Ford, Jette, Ferrari, Emanuela, Oommen, Joyce, Malinge, Sébastien, Lock, Richard B, Kees, Ursula R, Kotecha, Rishi S

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Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia von Cheung, Laurence C., de Kraa, Rebecca, Oommen, Joyce, Chua, Grace-Alyssa, Singh, Sajla, Hughes, Anastasia M., Ferrari, Emanuela, Ford, Jette, Chiu, Sung K., Stam, Ronald W., Kees, Ursula R., Malinge, Sebastien, Kotecha, Rishi S.

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The Bone Marrow Microenvironment in B-Cell Development and Malignancy von Hughes, Anastasia M, Kuek, Vincent, Kotecha, Rishi S, Cheung, Laurence C

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Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy von Cheung, Laurence C., Aya-Bonilla, Carlos, Cruickshank, Mark N., Chiu, Sung K., Kuek, Vincent, Anderson, Denise, Chua, Grace-Alyssa, Singh, Sajla, Oommen, Joyce, Ferrari, Emanuela, Hughes, Anastasia M., Ford, Jette, Kunold, Elena, Hesselman, Maria C., Post, Frederik, Faulk, Kelly E., Breese, Erin H., Guest, Erin M., Brown, Patrick A., Loh, Mignon L., Lock, Richard B., Kees, Ursula R., Jafari, Rozbeh, Malinge, Sébastien, Kotecha, Rishi S.

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New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment von Cheung, Laurence C., Tickner, Jennifer, Hughes, Anastasia M., Skut, Patrycja, Howlett, Meegan, Foley, Bree, Oommen, Joyce, Wells, Julia E., He, Bo, Singh, Sajla, Chua, Grace-Alyssa, Ford, Jette, Mullighan, Charles G., Kotecha, Rishi S., Kees, Ursula R.

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The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution von Anderson, Denise, Skut, Patrycja, Hughes, Anastasia M., Ferrari, Emanuela, Tickner, Jennifer, Xu, Jiake, Mullin, Benjamin H., Tang, Dave, Malinge, Sébastien, Kees, Ursula R., Kotecha, Rishi S., Lassmann, Timo, Cheung, Laurence C.

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Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia von Cheung, Laurence, de Kraa, Rebecca, Oommen, Joyce, Chua, Grace-Alyssa, Singh, Sajla, Hughes, Anastasia M, Ferrari, Emanuela, Ford, Jette, Chiu, Sung K, Stam, Ronald W, Kees, Ursula R, Malinge, Sébastien, Kotecha, Rishi

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Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic... von Cheung, Laurence C, Cruickshank, Mark N, Hughes, Anastasia M, Singh, Sajla, Chua, Grace-Alyssa, Ford, Jette, Ferrari, Emanuela, Oommen, Joyce, Malinge, Sébastien, Lock, Richard B, Kees, Ursula R, Kotecha, Rishi S

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Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic... von Cheung, Laurence, Cruickshank, Mark N, Hughes, Anastasia M, Singh, Sajla, Chua, Grace-Alyssa, Ford, Jette, Ferrari, Emanuela, Oommen, Joyce, Malinge, Sébastien, Lock, Richard B, Kees, Ursula R, Kotecha, Rishi S

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Diversity and Complexity in DNA Recognition by Transcription Factors von Badis, Gwenael, Berger, Michael F, Philippakis, Anthony A, Talukder, Shaheynoor, Gehrke, Andrew R, Jaeger, Savina A, Chan, Esther T, Metzler, Genita, Vedenko, Anastasia, Chen, Xiaoyu, Kuznetsov, Hanna, Wang, Chi-Fong, Coburn, David, Newburger, Daniel E, Morris, Quaid, Hughes, Timothy R, Bulyk, Martha L

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A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva von Shatilovich, Anastasia, Gade, Vamshidhar R, Pippel, Martin, Hoffmeyer, Tarja T, Tchesunov, Alexei V, Stevens, Lewis, Winkler, Sylke, Hughes, Graham M, Traikov, Sofia, Hiller, Michael, Rivkina, Elizaveta, Schiffer, Philipp H, Myers, Eugene W, Kurzchalia, Teymuras V

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AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease von Nikolaou, Nikolaos, Gathercole, Laura L., Marchand, Lea, Althari, Sara, Dempster, Niall J., Green, Charlotte J., van de Bunt, Martijn, McNeil, Catriona, Arvaniti, Anastasia, Hughes, Beverly A., Sgromo, Bruno, Gillies, Richard S., Marschall, Hanns-Ulrich, Penning, Trevor M., Ryan, John, Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 von Curran, Martin D., Roy, Sunando, Shaaban, Sharif, de Cesare, Mariateresa, Stark, Richard, Palmer, Steve, Jeffries, Aaron R., da Silva Filipe, Ana, Davis, Thomas, Collins, Jennifer, Williams, Thomas, Haldenby, Sam T., Cook, Kate, Davies, Robert, Kay, Sally, Poplawski, Radoslaw, Reynolds, Nicola, Moll, Robin J., Thornton, Alicia, Gatica-Wilcox, Bree, Louka, Stavroula F., Kraemer, Moritz U.G., Freeman, Timothy M., Abudahab, Khalil, Menegazzo, Mirko, Mason, Jenifer, Holmes, Alison, Curran, Tanya, Mookerjee, Siddharth, Munn, Robert, Davies, Alisha, Smith, Nikki, Cormie, Claire, Lo, Stephanie, Auckland, Cressida, Mollett, Guy, Harper, Katherine L., Bonner, Stephen, Padgett, Debra, Burton-Fanning, Shirelle, Bedford, Luke, Coupland, Lindsay, Wright, Victoria, Ball, Jonathan, Boswell, Tim, Duckworth, Nichola, Williams, Rebecca, Cogger, Benjamin J., Farr, Ben W., Thurston, Scott A.J., Bronner, Iraad F., Aigrain, Louise, Gallagher, Michael D., Miah, Shahjahan, Ramsay, Mary, Schaefer, Ulf, Manesis, Nikos, Allara, Elias, Nichols, Jenna, Vamos, Edith E., Hughes, Margaret, Wilson, Harry D., Wilson, Rebekah E., Thompson, Thomas, O’Brien, Sarah, Rudder, Steven, McCluggage, Kathryn, Bonfield, James, Liddle, Jennifier, Rowe, Will, Bevan, Paul, Clark, Richard, Cutts, Tim, Densem, Aiden, Dodd, David, Griffiths, Coline, Kay, Keely, Lensing, Stefanie, Lewis-Wade, Amanah, Mamun, Irfan, Martin, Matt, McClintock, Jo, Nathwani, Claire, Nicholson, Jon, Patel, Gaurang, Petersen, Arabella, Reynolds, Joe, Rudd, Luke, Sadri, Ramin, Sizer, Dale, Soria, Carmen Diaz, Sousa, Catarina, Squares, Janet, Stickland, Tim, Still, Ian, Symons, Edward, Uphill, James, Van, Philip Jansen, Voak, Paul, Corti, Davide

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Evaluation of methods for modeling transcription factor sequence specificity von Weirauch, Matthew T, Cote, Atina, Norel, Raquel, Annala, Matti, Zhao, Yue, Riley, Todd R, Saez-Rodriguez, Julio, Cokelaer, Thomas, Vedenko, Anastasia, Talukder, Shaheynoor, Bussemaker, Harmen J, Morris, Quaid D, Bulyk, Martha L, Stolovitzky, Gustavo, Hughes, Timothy R

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Using a Caenorhabditis elegans Parkinson's Disease Model to Assess Disease Progression and Therapy Efficiency von Hughes, Samantha, van Dop, Maritza, Kolsters, Nikki, van de Klashorst, David, Pogosova, Anastasia, Rijs, Anouk M

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Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial von Lyttle, Mark D, Rainford, Naomi E A, Gamble, Carrol, Messahel, Shrouk, Humphreys, Amy, Hickey, Helen, Woolfall, Kerry, Roper, Louise, Noblet, Joanne, Lee, Elizabeth D, Tate, Paul, Iyer, Anand, Evans, Vicki, Appleton, Richard E, Hardwick, Susie, Messahel, Shrouk, Lee, Elizabeth D, Buchanan, Mark, Lewis, Lucy, Hughes, Sharon, Rogers, Louise, Hopkins, Juliet, Lyttle, Mark D, Fernandez, Daphin, Potter, Sarah, Lavigne-Smith, Holly R, Moulsdale, Phoebe, Ross, James, Ramsey, Natasha, Hacking, Jo, Mullen, Niall, Corrigan, Paul P, Prudhoe, Sarah, Faza, Hani, Robinson, Gisela, Sunley, Rachel C, Unsworth, Vanessa, Criddle, John, Sheedy, Alyce B, Anderson, Mark, Bell, Kathryn, Devine, Kirsty, Scott, Alex, Kumar, Ramesh, Armstrong, Sonia, Sutherland, Emer, Helyer, Sinead, Riozzi, Paul, Cotton, Hannah, Downes, Alice J, Mollard, Helen, Roland, Damian, Gough, Christopher, Finucane, Sonya, Bevan, Catherine, Ramsay, Rebecca, Walton, Emily, Maney, Julie-Ann, Dalzell, Elizabeth, Millar, Muriel, Howells, Rachel J, Appelboam, Andy, Mackle, Daisy, Small, Jennie, Neil, Ashleigh, Choudhery, Vince, MacLeod, Stewart, O'Neill, Thomas, Grahamslaw, Julia, Parikh, Ami, Skene, Imogen, Potier de la Morandiere, Katherine, Wilson, Jill L, Danziger, Donna, Burke, Derek, Ramlakhan, Shammi, Evans, Jayne, Morcombe, Julie, Gormley, Stuart, Barling, Jason M, Cathie, Katrina, Bayreuther, Jane, Ensom, Ruth, Iqbal, Yasser, Rounding, Sarah, Bell, Claire, McLellan, Shona, Nyirenda, Maggie, Crome, Laura, Williamson, Neil, Alcock, Anastasia, Edwards, Sara, Morgan, Jeff, Powell, Colin VE, Ramesh, Chaniyil A, Kamal-Uddin, Solomon, Linney, Mike, Vamvakiti, Katia, Floyd, Sharon, Hobden, Gill

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Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo von Nikolaou, Nikolaos, Arvaniti, Anastasia, Appanna, Nathan, Sharp, Anna, Hughes, Beverly A, Digweed, Dena, Whitaker, Martin J, Ross, Richard, Arlt, Wiebke, Penning, Trevor M, Morris, Karen, George, Sherly, Keevil, Brian G, Hodson, Leanne, Gathercole, Laura L, Tomlinson, Jeremy W

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