Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties von Schwitalla, Sarah, Fingerle, Alexander A., Cammareri, Patrizia, Nebelsiek, Tim, Göktuna, Serkan I., Ziegler, Paul K., Canli, Ozge, Heijmans, Jarom, Huels, David J., Moreaux, Guenievre, Rupec, Rudolf A., Gerhard, Markus, Schmid, Roland, Barker, Nick, Clevers, Hans, Lang, Roland, Neumann, Jens, Kirchner, Thomas, Taketo, Makoto M., van den Brink, Gijs R., Sansom, Owen J., Arkan, Melek C., Greten, Florian R.

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ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation von Myant, Kevin B., Cammareri, Patrizia, McGhee, Ewan J., Ridgway, Rachel A., Huels, David J., Cordero, Julia B., Schwitalla, Sarah, Kalna, Gabriela, Ogg, Erinn-Lee, Athineos, Dimitris, Timpson, Paul, Vidal, Marcos, Murray, Graeme I., Greten, Florian R., Anderson, Kurt I., Sansom, Owen J.

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Think About the Environment: Cellular Reprogramming by the Extracellular Matrix von Huels, David J., Medema, Jan Paul

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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer von Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.

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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis von Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.

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Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells von Huels, D. J., Bruens, L., Hodder, M. C., Cammareri, P., Campbell, A. D., Ridgway, R. A., Gay, D. M., Solar-Abboud, M., Faller, W. J., Nixon, C., Zeiger, L. B., McLaughlin, M. E., Morrissey, E., Winton, D. J., Snippert, H. J., van Rheenen, J., Sansom, O. J.

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Retrograde movements determine effective stem cell numbers in the intestine von Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I. J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J. A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco

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The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues von Johnsson, Anna-Karin E, Dai, Yanfeng, Nobis, Max, Baker, Martin J, McGhee, Ewan J, Walker, Simon, Schwarz, Juliane P, Kadir, Shereen, Morton, Jennifer P, Myant, Kevin B, Huels, David J, Segonds-Pichon, Anne, Sansom, Owen J, Anderson, Kurt I, Timpson, Paul, Welch, Heidi C E

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Stem vs non-stem cell origin of colorectal cancer von Huels, D J, Sansom, O J

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The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut von Ramadan, Rana, Wouters, Valérie M., van Neerven, Sanne M., de Groot, Nina E., Garcia, Tania Martins, Muncan, Vanessa, Franklin, Olivia D., Battle, Michelle, Carlson, Karen Sue, Leach, Joshua, Sansom, Owen J., Boulard, Olivier, Chamaillard, Mathias, Vermeulen, Louis, Medema, Jan Paul, Huels, David J.

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Intestinal organoid co-culture protocol to study cell competition in vitro von van Neerven, Sanne M., Ramadan, Rana, van Driel, Milou S., Huels, David J., Vermeulen, Louis

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Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer von Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.

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The APC network regulates the removal of mutated cells from colonic crypts von Song, Je-Hoon, Huels, David J, Ridgway, Rachel A, Sansom, Owen J, Kholodenko, Boris N, Kolch, Walter, Cho, Kwang-Hyun

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Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition von Recasens-Alvarez, Carles, Alexandre, Cyrille, Kirkpatrick, Joanna, Nojima, Hisashi, Huels, David J., Snijders, Ambrosius P., Vincent, Jean-Paul

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mTORC1-mediated translational elongation limits intestinal tumour initiation and growth von Faller, William J., Jackson, Thomas J., Knight, John R. P., Ridgway, Rachel A., Jamieson, Thomas, Karim, Saadia A., Jones, Carolyn, Radulescu, Sorina, Huels, David J., Myant, Kevin B., Dudek, Kate M., Casey, Helen A., Scopelliti, Alessandro, Cordero, Julia B., Vidal, Marcos, Pende, Mario, Ryazanov, Alexey G., Sonenberg, Nahum, Meyuhas, Oded, Hall, Michael N., Bushell, Martin, Willis, Anne E., Sansom, Owen J.

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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia von Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.

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Modelled evaluation of multi-component meningococcal vaccine (Bexsero®) for the prevention of invasive meningococcal disease in infants and adolescents in the UK von HUELS, J., CLEMENTS, K. M., McGARRY, L. J., HILL, G. J., WASSIL, J., KESSABI, S.

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R-spondin Is More Than Just Wnt’s Sidekick von Huels, David J., Sansom, Owen J.

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E-cadherin can limit the transforming properties of activating β-catenin mutations von Huels, David J, Ridgway, Rachel A, Radulescu, Sorina, Leushacke, Marc, Campbell, Andrew D, Biswas, Sujata, Leedham, Simon, Serra, Stefano, Chetty, Runjan, Moreaux, Guenievre, Parry, Lee, Matthews, James, Song, Fei, Hedley, Ann, Kalna, Gabriela, Ceteci, Fatih, Reed, Karen R, Meniel, Valerie S, Maguire, Aoife, Doyle, Brendan, Söderberg, Ola, Barker, Nick, Watson, Alastair, Larue, Lionel, Clarke, Alan R, Sansom, Owen J

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TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis von Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J

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