Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation von Scott, James S, Birch, Alan M, Brocklehurst, Katy J, Broo, Anders, Brown, Hayley S, Butlin, Roger J, Clarke, David S, Davidsson, Öjvind, Ertan, Anne, Goldberg, Kristin, Groombridge, Sam D, Hudson, Julian A, Laber, David, Leach, Andrew G, MacFaul, Philip A, McKerrecher, Darren, Pickup, Adrian, Schofield, Paul, Svensson, Per H, Sörme, Pernilla, Teague, Joanne

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Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists von Scott, James S, Bowker, Suzanne S, Brocklehurst, Katy J, Brown, Hayley S, Clarke, David S, Easter, Alison, Ertan, Anne, Goldberg, Kristin, Hudson, Julian A, Kavanagh, Stefan, Laber, David, Leach, Andrew G, MacFaul, Philip A, Martin, Elizabeth A, McKerrecher, Darren, Schofield, Paul, Svensson, Per H, Teague, Joanne

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Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B‑Cell Lymphom... von Scott, James S, Degorce, Sébastien L, Anjum, Rana, Culshaw, Janet, Davies, Robert D. M, Davies, Nichola L, Dillman, Keith S, Dowling, James E, Drew, Lisa, Ferguson, Andrew D, Groombridge, Sam D, Halsall, Christopher T, Hudson, Julian A, Lamont, Scott, Lindsay, Nicola A, Marden, Stacey K, Mayo, Michele F, Pease, J. Elizabeth, Perkins, David R, Pink, Jennifer H, Robb, Graeme R, Rosen, Alan, Shen, Minhui, McWhirter, Claire, Wu, Dedong

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Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 L265P Diffuse Large B-Cell Lympho... von Scott, James S, Degorce, Sébastien L, Anjum, Rana, Culshaw, Janet, Davies, Robert D M, Davies, Nichola L, Dillman, Keith S, Dowling, James E, Drew, Lisa, Ferguson, Andrew D, Groombridge, Sam D, Halsall, Christopher T, Hudson, Julian A, Lamont, Scott, Lindsay, Nicola A, Marden, Stacey K, Mayo, Michele F, Pease, J Elizabeth, Perkins, David R, Pink, Jennifer H, Robb, Graeme R, Rosen, Alan, Shen, Minhui, McWhirter, Claire, Wu, Dedong

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Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors von Crawford, James J, Kenny, Peter W, Bowyer, Jonathan, Cook, Calum R, Finlayson, Jonathan E, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McDermott, Benjamin P, McGuire, Thomas M, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Dossetter, Alexander G

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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition von Dossetter, Alexander G., Bowyer, Jonathan, Cook, Calum R., Crawford, James J., Finlayson, Jonathan E., Heron, Nicola M., Heyes, Christine, Highton, Adrian J., Hudson, Julian A., Jestel, Anja, Krapp, Stephan, MacFaul, Philip A., McGuire, Thomas M., Morley, Andrew D., Morris, Jeffrey J., Page, Ken M., Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline

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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor f... von Dossetter, Alexander G, Beeley, Howard, Bowyer, Jonathan, Cook, Calum R, Crawford, James J, Finlayson, Jonathan E, Heron, Nicola M, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Kenny, Peter W, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McGuire, Thomas M, Gutierrez, Pablo Morentin, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine

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Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas von Burrows, Jeremy N., Cumming, John G., Fillery, Shaun M., Hamlin, Gordon A., Hudson, Julian A., Jackson, Ruth J., McLaughlin, Sharon, Shaw, John S.

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Facile synthesis of 3-alkoxyindoles via rhodium(II)-catalysed diazoindole O–H insertion reactions von Kettle, Jason G, Faull, Alan W, Fillery, Shaun M, Flynn, Anthony P, Hoyle, Marcus A, Hudson, Julian A

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ChemInform Abstract: An Efficient Method for Reductive Amination of Carbonyl Compounds under Nonacidic Conditions von Hudson, Julian A., Sweeney, J. B.

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A Novel Approach to Dual-Acting Thromboxane Receptor Antagonist/Synthase Inhibitors Based on the Link of 1,3-Dioxane-Thromboxane Receptor Antagonists and -Thromboxane Synthase Inhi... von Ackerley, Norman, Brewster, Andrew G, Brown, George R, Clarke, David S, Foubister, Alan J, Griffin, Stephen J, Hudson, Julian A, Smithers, Michael J, Whittamore, Paul R. O

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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists von Scott, James S., Birch, Alan M., Brocklehurst, Katy J., Brown, Hayley S., Goldberg, Kristin, Groombridge, Sam D., Hudson, Julian A., Leach, Andrew G., MacFaul, Philip A., McKerrecher, Darren, Poultney, Ruth, Schofield, Paul, Svensson, Per H.

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Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors von Scott, James S., Berry, David J., Brown, Hayley S., Buckett, Linda, Clarke, David S., Goldberg, Kristin, Hudson, Julian A., Leach, Andrew G., MacFaul, Philip A., Raubo, Piotr, Robb, Graeme

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Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00156c von Scott, James S, Berry, David J, Brown, Hayley S, Buckett, Linda, Clarke, David S, Goldberg, Kristin, Hudson, Julian A, Leach, Andrew G, MacFaul, Philip A, Raubo, Piotr, Robb, Graeme

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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonistsThis article is part of a MedChemComm 'New Talents' issue highlighting the work of... von Scott, James S, Birch, Alan M, Brocklehurst, Katy J, Brown, Hayley S, Goldberg, Kristin, Groombridge, Sam D, Hudson, Julian A, Leach, Andrew G, MacFaul, Philip A, McKerrecher, Darren, Poultney, Ruth, Schofield, Paul, Svensson, Per H

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Acid catalyzed racemization of 1-(heterocyclyloxy)-2,3-propanediols von Barlow, Jeffrey J, Block, Michael H, Hudson, Julian A, Leach, Alison, Longridge, Jethro L, Main, Brian G, Nicholson, Stuart

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ChemInform Abstract: Facile Synthesis of 3-Alkoxyindoles via Rhodium(II)-Catalyzed Diazoindole O-H Insertion Reactions von Kettle, Jason G., Faull, Alan W., Fillery, Shaun M., Flynn, Anthony P., Hoyle, Marcus A., Hudson, Julian A.

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An epigenome-wide association study of total serum immunoglobulin E concentration von Liang, Liming, Willis-Owen, Saffron A. G., Laprise, Catherine, Wong, Kenny C. C., Davies, Gwyneth A., Hudson, Thomas J., Binia, Aristea, Hopkin, Julian M., Yang, Ivana V., Grundberg, Elin, Busche, Stephan, Hudson, Marie, Rönnblom, Lars, Pastinen, Tomi M., Schwartz, David A., Lathrop, G. Mark, Moffatt, Miriam F., Cookson, William O. C. M.

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Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor von Terhzaz, Selim, Cabrero, Pablo, Robben, Joris H, Radford, Jonathan C, Hudson, Brian D, Milligan, Graeme, Dow, Julian A T, Davies, Shireen-A

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Structural snapshots of the SCR reaction mechanism on Cu-SSZ-13 von Günter, Tobias, Carvalho, Hudson W P, Doronkin, Dmitry E, Sheppard, Thomas, Glatzel, Pieter, Atkins, Andrew J, Rudolph, Julian, Jacob, Christoph R, Casapu, Maria, Grunwaldt, Jan-Dierk

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