LGG-12. TRAMETINIB FOR PEDIATRIC LOW GRADE GLIOMAS: A SINGLE INSTITUTION EXPERIENCE von Barbour, Mustafa, Huang, Michael Angelo

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HGG-26. Comprehensive Genomic Profiling of Pediatric and AYA High-Grade Gliomas Reveals a High Prevalence of ATRX and Homologous Recombination Repair (HRR) Mutations von Kuang, Zheng, Hiemenz, Matthew, Huang, Michael Angelo

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LGG-02. PEDIATRIC LOW-GRADE GLIOMA RISK STRATIFICATION IN THE MOLECULAR ERA von Hata, Jessica, Barbour, Mustafa, Huang, Michael Angelo

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Improving pneumococcal vaccination rates in pediatric acute lymphoblastic leukemia/lymphoblastic lymphoma von Chang, Simone, Cheerva, Alexandra, Huang, Michael Angelo, McGowan, Kerry, Knapp, Esther E, Raj, Ashok, Slone, Natalie, Zhao, Jun, Tse, William T, Barbour, Mustafa

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A transcriptional switch governs fibroblast activation in heart disease von Alexanian, Michael, Przytycki, Pawel F., Micheletti, Rudi, Padmanabhan, Arun, Ye, Lin, Travers, Joshua G., Gonzalez-Teran, Barbara, Silva, Ana Catarina, Duan, Qiming, Ranade, Sanjeev S., Felix, Franco, Linares-Saldana, Ricardo, Li, Li, Lee, Clara Youngna, Sadagopan, Nandhini, Pelonero, Angelo, Huang, Yu, Andreoletti, Gaia, Jain, Rajan, McKinsey, Timothy A., Rosenfeld, Michael G., Gifford, Casey A., Pollard, Katherine S., Haldar, Saptarsi M., Srivastava, Deepak

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Durvalumab, with or without tremelimumab, plus platinum–etoposide versus platinum–etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updat... von Chen, Yuanbin, Reinmuth, Niels, Hotta, Katsuyuki, Özgüroğlu, Mustafa, Ji, Jun Ho, Garassino, Marina Chiara, Poltoratskiy, Artem, Ponce, Santiago, Bondarenko, Igor, Conev, Nikolay V, Armstrong, Jon, Byrne, Natalie, Jiang, Haiyi, Paz-Ares, Luis, Voitko, Nataliia, Poltoratskiy, Artem, Bondarenko, Igor, Chen, Yuanbin, Özgüroglu, Mustafa, Conev, Nikolay, Burghuber, Otto, Moiseenko, Vladimir, Reinmuth, Niels, Ursol, Grygorii, Pajkos, Gábor, Verderame, Francesco, Smolin, Alexey, Göksel, Tuncay, Dakhil, Shaker, Lee, Jong-Seok, Garcia Campelo, Maria Rosario, Alacacioglu, Ahmet, Casarini, Ignacio, Ilieva, Rumyana, Somfay, Attila, Roila, Fausto, Urda, Michal, Majem Tarruella, Margarita, Bettini, Anna Cecilia, Okamoto, Isamu, Mandziuk, Slawomir, Domine Gomez, Manuel, Wu, Shang-Yin, Knoble, Jeanna, Venkova, Violetka, Laack, Eckart, Bischoff, Helge, Fülöp, Andrea, Telekes, András, Kanda, Shintaro, Nakahara, Yasuharu, Lin, Sheng-Hao, Schaefer, Eric, Nikolinakos, Petros, Schneider, Jeffrey, Kultan, Juraj, Kolek, Vitezslav, Lee, Kyung Hee, Goloborodko, Olexandr, Kolesnik, Oleksii, Ostapenko, Yuriy, Stilwill, Joseph, De Marchi, Pedro Rafael Martins, Krasteva, Rositsa, Koubkova, Leona, Grohe, Christian, Heching, Norman Isaac, Harada, Daijiro, Nogami, Naoyuki, Nokihara, Hiroshi, Goto, Hisatsugu, Staal van den Brekel, Agnes, Ganea, Doina, Popova, Ekaterina, Sakaeva, Dina, Stresko, Marian, Demo, Pavol, Hsia, Te-Chun, Lee, Kang-Yun, Zarba, Juan Jose, Pastor, Andrea Viviana, Zukin, Mauro, Calabrich, Aknar, Dudov, Asen, Lang, Susanne, Kanazawa, Kenya, Hiltermann, Jeroen, Shparyk, Yaroslav, Kryzhanivska, Anna, Jamil, Rodney, Williamson, Michael, Han, Zhigang, Wang, Mengzhao, Li, Wei, Feng, Jifeng, Zhou, Xiangdong, Hu, Yi, Nan, Kejun, Zhang, Wei, Lin, Zhong

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Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study von Xu, Jianlin, Xu, Xuankuo, Huang, Chao, Angelo, James, Oliveira, Christopher L, Xu, Mengmeng, Xu, Xia, Temel, Deniz, Ding, Julia, Ghose, Sanchayita, Borys, Michael C, Li, Zheng Jian

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Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia von Liu, Hong, Zhang, Yujin, Wu, Hongyu, D’Alessandro, Angelo, Yegutkin, Gennady G, Song, Anren, Sun, Kaiqi, Li, Jessica, Cheng, Ning-Yuan, Huang, Aji, Edward Wen, Yuan, Weng, Ting Ting, Luo, Fayong, Nemkov, Travis, Sun, Hong, Kellems, Rodney E, Karmouty-Quintana, Harry, Hansen, Kirk C, Zhao, Bihong, Subudhi, Andrew W, Jameson-Van Houten, Sonja, Julian, Colleen G, Lovering, Andrew T, Eltzschig, Holger K, Blackburn, Michael R, Roach, Robert C, Xia, Yang

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R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis von Huang, Helen J, Angelo, Laura S, Rodon, Jordi, Sun, Michael, Kuenkele, Klaus-Peter, Parsons, Henrique A, Trent, Jonathan C, Kurzrock, Razelle

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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion von Leuzzi, Giuseppe, Vasciaveo, Alessandro, Taglialatela, Angelo, Chen, Xiao, Firestone, Tessa M., Hickman, Allison R., Mao, Wendy, Thakar, Tanay, Vaitsiankova, Alina, Huang, Jen-Wei, Cuella-Martin, Raquel, Hayward, Samuel B., Kesner, Jordan S., Ghasemzadeh, Ali, Nambiar, Tarun S., Ho, Patricia, Rialdi, Alexander, Hebrard, Maxime, Li, Yinglu, Gao, Jinmei, Gopinath, Saarang, Adeleke, Oluwatobi A., Venters, Bryan J., Drake, Charles G., Baer, Richard, Izar, Benjamin, Guccione, Ernesto, Keogh, Michael-Christopher, Guerois, Raphael, Sun, Lu, Lu, Chao, Califano, Andrea, Ciccia, Alberto

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The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2 von Huisman, Menno V, Rothman, Kenneth J, Paquette, Miney, Teutsch, Christine, Diener, Hans-Christoph, Dubner, Sergio J, Halperin, Jonathan L, Ma, Chang Sheng, Zint, Kristina, Elsaesser, Amelie, Bartels, Dorothee B, Lip, Gregory Y H

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Comparing Data Generated Using Multiparametric Flow Cytometry, Capillary Electrophoresis, and Next-Generation Sequencing in a Cohort of B-Cell Lymphoproliferative Disorder Samples von Arias, Angelo, Palekha, Serge, Tong, Tina, Apilado, Robert, Chanco, Michael, Li, Hongyi, Zimmerman, Micah, Wong, Allyson, Willis, Jason, Andrews, Robert, Thornes, Jordan, Huang, Ying, Miller, Jeffrey E

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DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy von Lin, Hsin-Pin, Petersen, Jennifer D, Gilsrud, Alexandra J, Madruga, Angelo, D’Silva, Theresa M, Huang, Xiaoping, Shammas, Mario K, Randolph, Nicholas P, Johnson, Kory R, Li, Yan, Jones, Drew R, Pacold, Michael E, Narendra, Derek P

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Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology von Compton, Carolyn C., De Marzo, Angelo M., Debnath, Jayanta, Eaton, Keith D., Elenitoba-Johnson, Kojo, Fiorentino, Michelangelo, French, Christopher A., Fuchs, Thomas J., Giangaspero, Felice, Huang, Jiaoti, Iafrate, A. John, Ittmann, Michael M., Jensen, Roy A., Kim, Annette S., Loda, Massimo, Lorenz, Robin G., Lotan, Tamara L., Maitra, Anirban, Meijer, Gerrit A., Mitchell, Richard N., Parwani, Anil V., Pezzella, Francesco, Pikarsky, Eli, Reis-Filho, Jorge S., Richardson, Andrea L., Rubin, Mark A., True, Lawrence D.

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Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes von Scala, Marcello, Nishikawa, Masashi, Ito, Hidenori, Tabata, Hidenori, Khan, Tayyaba, Accogli, Andrea, Davids, Laura, Ruiz, Anna, Chiurazzi, Pietro, Cericola, Gabriella, Schulte, Björn, Monaghan, Kristin G, Begtrup, Amber, Torella, Annalaura, Pinelli, Michele, Denommé-Pichon, Anne Sophie, Vitobello, Antonio, Racine, Caroline, Mancardi, Maria Margherita, Kiss, Courtney, Guerin, Andrea, Wu, Wendy, Gabau Vila, Elisabeth, Mak, Bryan C, Martinez-Agosto, Julian A, Gorin, Michael B, Duz, Bugrahan, Bayram, Yavuz, Carvalho, Claudia M B, Vengoechea, Jaime E, Chitayat, David, Tan, Tiong Yang, Callewaert, Bert, Kruse, Bernd, Bird, Lynne M, Faivre, Laurence, Zollino, Marcella, Biskup, Saskia, Striano, Pasquale, Nigro, Vincenzo, Severino, Mariasavina, Capra, Valeria, Costain, Gregory, Nagata, Koh Ichi

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An Overview of Verification and Validation Challenges for Inspection Robots von Fisher, Michael, Cardoso, Rafael C., Collins, Emily C., Dadswell, Christopher, Dennis, Louise A., Dixon, Clare, Farrell, Marie, Ferrando, Angelo, Huang, Xiaowei, Jump, Mike, Kourtis, Georgios, Lisitsa, Alexei, Luckcuck, Matt, Luo, Shan, Page, Vincent, Papacchini, Fabio, Webster, Matt

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Abstract 4141686: Chromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart Failure von Alexanian, Michael, Padmanabhan, Arun, Nishino, Tomohiro, Travers, Joshua, Ye, Lin, Angelo, Pelonero, Lee, Clara, Sadagopan, Nandhini, Huang, Yu, Auclair, Kirsten, Zhu, Ada, An, Yuqian, Ekstrand, Christina, Martinez, Cassandra, Gonzalez Teran, Barbara, Flanigan, Will, Kee-Seon Kim, Charis, Conradson, Devon, Gardner, Zachary, Li, Li, Costa, Mauro, Jain, Rajan, Charo, Israel, Combes, Alexis, Haldar, Saptarsi, Pollard, Katherine, Vagnozzi, Ronald, McKinsey, Timothy, Przytycki, Pawel, Srivastava, Deepak

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Sustained Immunogenicity of 2-dose Human Papillomavirus 16/18 AS04-adjuvanted Vaccine Schedules in Girls Aged 9–14 Years: A Randomized Trial von Huang, Li-Min, Puthanakit, Thanyawee, Cheng-Hsun, Chiu, Ren-Bin, Tang, Schwarz, Tino, Pellegrino, Angelo, Esposito, Susanna, Frenette, Louise, McNeil, Shelly, Durando, Paolo, Rheault, Paul, Giaquinto, Carlo, Horn, Michael, Petry, Karl Ulrich, Peters, Klaus, Azhar, Toma, Hillemanns, Peter, De Simoni, Stephanie, Friel, Damien, Pemmaraju, Suryakiran, Hezareh, Marjan, Thomas, Florence, Descamps, Dominique, Folschweiller, Nicolas, Struyf, Frank

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Abstract 14797: Single Cell Multi-Modal Analyses Reveal Epigenomic and Transcriptomic Basis Underlying Cardiac Defects in Maternal Diabetes von Nishino, Tomohiro, Ranade, Sanjeev, Angelo, Pelonero, van Soldt, Benjamin J, Ye, Lin, Alexanian, Michael, Koback, Frances, Huang, Yu, Sadagopan, Nandhini, Padmanabhan, Arun, Thomas, Reuben, van Bemmel, Joke, Gifford, Casey, Costa, Mauro, Srivastava, Deepak

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Somatic loss of ATM is a late event in pancreatic tumorigenesis von Paranal, Raymond M, Jiang, Zhengdong, Hutchings, Danielle, Kryklyva, Valentyna, Gauthier, Christian, Fujikura, Kohei, Nanda, Neha, Huang, Bo, Skaro, Michael, Wolfgang, Christopher L, He, Jin, Klimstra, David S, Brand, Randall E, Singhi, Aatur D, DeMarzo, Angelo, Zheng, Lei, Goggins, Michael, Brosens, Lodewijk Aa, Hruban, Ralph H, Klein, Alison P, Lotan, Tamara, Wood, Laura D, Roberts, Nicholas J

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