Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer-Targeted Therapies von O'Brien, Neil A, Huang, Holly K T, McDermott, Martina S J, Madrid, Athena M, Luo, Tong, Ayala, Raul, Issakhanian, Shawnt, Gong, Ke Wei, Lu, Ming, Zhang, Jun, Slamon, Dennis J

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Efficacy and safety of FLAG‐IDA as front‐line therapy in de novo paediatric acute myeloid leukaemia population von Doan, Andrew, Huang, Holly K. T., Hadar, Ari J., Malvar, Jemily, Rushing, Teresa, Raca, Gordana, Kovach, Alexandra E., Freyer, David R., Parekh, Chintan, Stokke, Jamie, Posch, Leila C., Dao, Julie, Bhojwani, Deepa, Gaynon, Paul, Orgel, Etan

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Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis von Choi, Angela, Koch, Matthew, Wu, Kai, Chu, Laurence, Ma, LingZhi, Hill, Anna, Nunna, Naveen, Huang, Wenmei, Oestreicher, Judy, Colpitts, Tonya, Bennett, Hamilton, Legault, Holly, Paila, Yamuna, Nestorova, Biliana, Ding, Baoyu, Montefiori, David, Pajon, Rolando, Miller, Jacqueline M., Leav, Brett, Carfi, Andrea, McPhee, Roderick, Edwards, Darin K.

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Ten simple rules for women principal investigators during a pandemic von Kreeger, Pamela K, Brock, Amy, Gibbs, Holly C, Grande-Allen, K Jane, Huang, Alice H, Masters, Kristyn S, Rangamani, Padmini, Reagan, Michaela R, Servoss, Shannon L

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Endotyping Chronic Obstructive Pulmonary Disease, Bronchiectasis, and the "Chronic Obstructive Pulmonary Disease-Bronchiectasis Association" von Huang, Jeffrey T-J, Cant, Erin, Keir, Holly R, Barton, Alun K, Kuzmanova, Elena, Shuttleworth, Morven, Pollock, Jennifer, Finch, Simon, Polverino, Eva, Bottier, Mathieu, Dicker, Alison J, Shoemark, Amelia, Chalmers, James D

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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications von Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

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Sputum Proteomics in Nontuberculous Mycobacterial Lung Disease von Hull, Rebecca C., Huang, Jeffrey T.J., Barton, Alun K., Keir, Holly R., Ellis, Huw, Cookson, William O.C., Moffatt, Miriam F., Loebinger, Michael R., Chalmers, James D.

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Forest carbon emissions from cropland expansion in the Brazilian Cerrado biome von Noojipady, Praveen, Morton, C Douglas, Macedo, N Marcia, Victoria, C Daniel, Huang, Chengquan, Gibbs, K Holly, Bolfe, L Edson

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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses von Tan, Tiong Kit, Rijal, Pramila, Rahikainen, Rolle, Keeble, Anthony H., Schimanski, Lisa, Hussain, Saira, Harvey, Ruth, Hayes, Jack W. P., Edwards, Jane C., McLean, Rebecca K., Martini, Veronica, Pedrera, Miriam, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Zagrajek, Adrian K., Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Tully, Matthew, Moffat, Katy, Chiu, Chris, Waters, Ryan, Gray, Ashley, Azhar, Mehreen, Mioulet, Valerie, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Hammond, John A., Tchilian, Elma, Charleston, Bryan, Bailey, Dalan, Tuthill, Tobias J., Graham, Simon P., Duyvesteyn, Helen M. E., Malinauskas, Tomas, Huo, Jiandong, Tree, Julia A., Buttigieg, Karen R., Owens, Raymond J., Carroll, Miles W., Daniels, Rodney S., McCauley, John W., Stuart, David I., Huang, Kuan-Ying A., Howarth, Mark, Townsend, Alain R.

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Factors affecting outdoor physical activity in extreme temperatures in a sub-tropical Chinese urban population: an exploratory telephone survey von Ho, Janice Y, Lam, Holly Y C, Huang, Zhe, Liu, Sida, Goggins, William B, Mo, Phoenix K H, Chan, Emily Y Y

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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice von Rickard, James A, Anderton, Holly, Etemadi, Nima, Nachbur, Ueli, Darding, Maurice, Peltzer, Nieves, Lalaoui, Najoua, Lawlor, Kate E, Vanyai, Hannah, Hall, Cathrine, Bankovacki, Aleks, Gangoda, Lahiru, Wong, Wendy Wei-Lynn, Corbin, Jason, Huang, Chunzi, Mocarski, Edward S, Murphy, James M, Alexander, Warren S, Voss, Anne K, Vaux, David L, Kaiser, William J, Walczak, Henning, Silke, John

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Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b–2 trial von Loi, Sherene, Giobbie-Hurder, Anita, Gombos, Andrea, Bachelot, Thomas, Hui, Rina, Curigliano, Giuseppe, Campone, Mario, Biganzoli, Laura, Bonnefoi, Hervé, Jerusalem, Guy, Bartsch, Rupert, Rabaglio-Poretti, Manuela, Kammler, Roswitha, Maibach, Rudolf, Smyth, Mark J, Di Leo, Angelo, Colleoni, Marco, Viale, Giuseppe, Regan, Meredith M, André, Fabrice, Fumagalli, Debora, Gelber, Richard D, Goulioti, Theodora, Hiltbrunner, Anita, Hui, Rita, Roschitzki, Heidi, Ruepp, Barbara, Boyle, Fran, Stahel, Rolf, Aebi, Stefan, Coates, Alan S, Goldhirsch, Aron, Karlsson, Per, Kössler, Ingrid, Fournarakou, Stamatina, Gasca, Adriana, Pfister, Rita, Ribeli-Hofmann, Sabrina, Weber, Magdelena, Celotto, Daniela, Comune, Carmen, Frapolli, Michela, Sánchez-Hohl, Magdalena, Huang, Hui, Mahoney, Caitlin, Price, Karen, Scott, Karolyn, Shaw, Holly, Fischer, Susan, Greco, Monica, King, Colleen, Andrighetto, Stefania, Piccart-Gebhart, Martine, Findlay, Heather, Jenkins, Michelle, Karantza, Vassiliki, Mejia, Jaime, Schneier, Patrick

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Immune response to SARS-CoV-2 after a booster of mRNA-1273: an open-label phase 2 trial von Chu, Laurence, Vrbicky, Keith, Montefiori, David, Huang, Wenmei, Nestorova, Biliana, Chang, Ying, Carfi, Andrea, Edwards, Darin K., Oestreicher, Judy, Legault, Holly, Dutko, Frank J., Girard, Bethany, Pajon, Rolando, Miller, Jacqueline M., Das, Rituparna, Leav, Brett, McPhee, Roderick

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A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated von Follmann, D, Fintzi, J, Fay, MP, Janes, HE, Baden, LR, El Sahly, HM, Fleming, TR, Mehrotra, DV, Carpp, LN, Juraska, M, Benkeser, D, Donnell, D, Fong, YY, Han, S, Hirsch, I, Huang, Y, Huang, YD, Hyrien, O, Luedtke, A, Carone, M, Nason, M, Vandebosch, A, Zhou, HH, Cho, I, Gabriel, E, Kublin, JG, Cohen, MS, Corey, L, Gilbert, PB, Neuzil, KM

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Secretin Stimulates Biliary Cell Proliferation by Regulating Expression of MicroRNA 125b and MicroRNA let7a in Mice von Glaser, Shannon, Meng, Fanyin, Han, Yuyan, Onori, Paolo, Chow, Billy K, Francis, Heather, Venter, Julie, McDaniel, Kelly, Marzioni, Marco, Invernizzi, Pietro, Ueno, Yoshiyuki, Lai, Jia-ming, Huang, Li, Standeford, Holly, Alvaro, Domenico, Gaudio, Eugenio, Franchitto, Antonio, Alpini, Gianfranco

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Acetate Dependence of Tumors von Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.

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Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms von Zhu, Rongjia, Yan, Tingdong, Feng, Yingmei, Liu, Yan, Cao, Hongcui, Peng, Gongxin, Yang, Yanlei, Xu, Zhen, Liu, Jingqi, Hou, Wei, Wang, Xiaoyue, Li, Zhe, Deng, Luchan, Wang, Shihua, Li, Jing, Han, Qin, Li, Hongling, Shan, Guangliang, Cao, Yinghao, An, Xingyan, Yan, Jianshe, Zhang, Zhonghui, Li, Huafei, Qu, Xuebin, Zhu, Jiaqi, Zhou, Shumin, Wang, Jiao, Zhang, Fengchun, Gao, Jinming, Jin, Ronghua, Xu, Dayong, Ma, Yan-Qing, Huang, Tao, Peng, Shuang, Zheng, Zhi, Stambler, Ilia, Gilson, Eric, Lim, Lee Wei, Moskalev, Alexey, Cano, Antonio, Chakrabarti, Sasanka, Ulfhake, Brun, Su, Huanxing, Xu, Haoying, Xu, Sihuan, Wei, Feng, Brown-Borg, Holly M., Min, Kyung-Jin, Ellison-Hughes, Georgina, Caruso, Calogero, Jin, Kunlin, Zhao, Robert Chunhua

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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer von Riggan, Marjorie J, Beesley, Jonathan, Soucy, Penny, Aalfs, Cora M, Adams, Marcia, Arnold, Norbert, Arun, Banu K, Bean, Yukie, Bermisheva, Marina, Birrer, Michael J, Blankstein, Kenneth, Bonanni, Bernardo, Bradbury, Angela R, Broberg, Per, Campbell, Ian, Cannioto, Rikki, Cescon, Terence, Chan, Salina B, Chanock, Stephen, Claes, Kathleen B M, Conner, Thomas, Dansonka-Mieszkowska, Agnieszka, Davidson, Rosemarie, Dürst, Matthias, Ellis, Steve, Fasching, Peter A, Ferguson, Sarah, Frost, Debra, Gentry-Maharaj, Aleksandra, Gore, Martin, Gronwald, Jacek, Gruber, Stephen, Håkansson, Niclas, Hauke, Jan, Hildebrandt, Michelle A T, Høgdall, Claus K, Hogervorst, Frans B L, Hulick, Peter J, Imyanitov, Evgeny N, Izatt, Louise, Izquierdo, Angel, Jensen, Allan, Karnezis, Anthony, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lee, Jong Won, Lele, Shashikant B, Leroux, Dominique, Lesueur, Fabienne, Lilyquist, Jenna, Mai, Phuong L, McAlpine, Jessica N, McGuire, Valerie, Mensenkamp, Arjen R, Modugno, Francesmary, Moes-Sosnowska, Joanna, Mulligan, Anna Marie, Musinsky, Jacob, Nedergaard, Lotte, Ness, Roberta B, Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L, Onland-Moret, N Charlotte, Paul, James, Pelttari, Liisa M, Pezzani, Lidia, Phillips, Kelly-Anne, Poppe, Bruce, Prieur, Fabienne, Prokofyeva, Darya, Rice, Patricia, Rodriguez, Gustavo C, Rookus, Matti A, Senter, Leigha, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E, Stadler, Zsofia, Sutphen, Rebecca, Sutter, Christian, Szabo, Csilla I, Terry, Kathryn L, Tihomirova, Laima, Tung, Nadine, Van Heetvelde, Mattias, Varon-Mateeva, Raymonda, Walsh, Christine, Wappenschmidt, Barbara, Webb, Penelope M, Weinberg, Clarice R, Weitzel, Jeffrey N, Yang, Hannah, Goodman, Marc T, Park, Sue K, Risch, Harvey A, Offit, Kenneth, Simard, Jacques, Chenevix-Trench, Georgia, Goode, Ellen L

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Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma von Kogiso, Mari, Qi, Lin, Du, Yuchen, Braun, Frank K., Zhang, Huiyuan, Huang, L. Frank, Guo, Lei, Huang, Yulun, Teo, Wan-Yee, Lindsay, Holly, Zhao, Sibo, Injac, Sarah G., Liu, Zhen, Mehta, Vidya, Tran, Diep, Li, Feng, Baxter, Patricia A., Su, Jack M., Perlaky, Laszlo, Parsons, D. Williams, Chintagumpala, Murali, Adesina, Adekunle, Song, Yongcheng, Li, Xiao-Nan

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Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes von Zhou, Xueya, Feliciano, Pamela, Shu, Chang, Wang, Tianyun, Astrovskaya, Irina, Hall, Jacob B., Obiajulu, Joseph U., Wright, Jessica R., Murali, Shwetha C., Xu, Simon Xuming, Brueggeman, Leo, Thomas, Taylor R., Marchenko, Olena, Fleisch, Christopher, Barns, Sarah D., Snyder, LeeAnne Green, Han, Bing, Chang, Timothy S., Turner, Tychele N., Harvey, William T., Nishida, Andrew, O’Roak, Brian J., Geschwind, Daniel H., Michaelson, Jacob J., Volfovsky, Natalia, Eichler, Evan E., Shen, Yufeng, Chung, Wendy K.

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