Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics von Cragg, Mark S, Kuroda, Junya, Puthalakath, Hamsa, Huang, David C S, Strasser, Andreas

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Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease von ROBERTS, Andrew W, SEYMOUR, John F, YUE CUI, BUSMAN, Todd A, MCKEEGAN, Evelyn M, KRIVOSHIK, Andrew P, ENSCHEDE, Sari H, HUMERICKHOUSE, Rod, BROWN, Jennifer R, WIERDA, William G, KIPPS, Thomas J, SEONG LIN KHAW, CARNEY, Dennis A, HE, Simon Z, HUANG, David C. S, HAO XIONG

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XIAP discriminates between type I and type II FAS-induced apoptosis von Strasser, Andreas, Kaufmann, Thomas, Jost, Philipp J, Grabow, Stephanie, Gray, Daniel, McKenzie, Mark D, Nachbur, Ueli, Huang, David C. S, Bouillet, Philippe, Thomas, Helen E, Borner, Christoph, Silke, John

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PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling von Yao, Bing, Gui, Tao, Zeng, Xiangwei, Deng, Yexuan, Wang, Zhi, Wang, Ying, Yang, Dongjun, Li, Qixiang, Xu, Peipei, Hu, Ruifeng, Li, Xinyu, Chen, Bing, Wang, Jin, Zen, Ke, Li, Haitao, Davis, Melissa J., Herold, Marco J., Pan, Hua-Feng, Jiang, Zhi-Wei, Huang, David C. S., Liu, Ming, Ju, Junyi, Zhao, Quan

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Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 von Oakes, Samantha R, Vaillant, François, Lim, Elgene, Lee, Lily, Breslin, Kelsey, Feleppa, Frank, Deb, Siddhartha, Ritchie, Matthew E, Takano, Elena, Ward, Teresa, Fox, Stephen B, Generali, Daniele, Smyth, Gordon K, Strasser, Andreas, Huang, David C. S, Visvader, Jane E, Lindeman, Geoffrey J

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Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis von Yuan, Zheng, van Delft, Mark F, Li, Mark Xiang, Sumardy, Fransisca, Smith, Brian J, Huang, David C S, Lessene, Guillaume, Khakam, Yelena, Jin, Ruitao, He, Sitong, Smith, Nicholas A, Birkinshaw, Richard W, Czabotar, Peter E, Dewson, Grant

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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection von Masamsetti, V. Pragathi, Low, Ronnie Ren Jie, Mak, Ka Sin, O’Connor, Aisling, Riffkin, Chris D., Lamm, Noa, Crabbe, Laure, Karlseder, Jan, Huang, David C. S., Hayashi, Makoto T., Cesare, Anthony J.

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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak von Willis, Simon N, Fletcher, Jamie I, Kaufmann, Thomas, van Delft, Mark F, Chen, Lin, Czabotar, Peter E, Ierino, Helen, Lee, Erinna F, Fairlie, W. Douglas, Bouillet, Philippe, Strasser, Andreas, Kluck, Ruth M, Adams, Jerry M, Huang, David C.S

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Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function von Schoenwaelder, Simone M., Yuan, Yuping, Josefsson, Emma C., White, Michael J., Yao, Yu, Mason, Kylie D., O'Reilly, Lorraine A., Henley, Katya J., Ono, Akiko, Hsiao, Sarah, Willcox, Abbey, Roberts, Andrew W., Huang, David C.S., Salem, Hatem H., Kile, Benjamin T., Jackson, Shaun P.

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BCL2 and MCL1 inhibitors for hematologic malignancies von Roberts, Andrew W., Wei, Andrew H., Huang, David C.S.

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Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity von Bouillet, Philippe, Metcalf, Donald, David C. S. Huang, Tarlinton, David M., Tom W. H. Kay, Köntgen, Frank, Adams, Jerry M., Strasser, Andreas

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Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1 von Kvansakul, Marc, Wei, Andrew H, Fletcher, Jamie I, Willis, Simon N, Chen, Lin, Roberts, Andrew W, Huang, David C S, Colman, Peter M

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Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II von Chambers, Jennifer M, Lindqvist, Lisa M, Webb, Andrew, Huang, David C. S, Savage, G. Paul, Rizzacasa, Mark A

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Mesenchymal stromal cell apoptosis is required for their therapeutic function von Pang, Swee Heng Milon, D’Rozario, Joshua, Mendonca, Senora, Bhuvan, Tejasvini, Payne, Natalie L., Zheng, Di, Hisana, Assifa, Wallis, Georgia, Barugahare, Adele, Powell, David, Rautela, Jai, Huntington, Nicholas D., Dewson, Grant, Huang, David C. S., Gray, Daniel H. D., Heng, Tracy S. P.

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Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak von Lindqvist, Lisa M., Heinlein, Melanie, Huang, David C. S., Vaux, David L.

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival von Schwickart, Martin, Dornan, David, Huang, David C. S, Liu, Jinfeng, Lill, Jennie R, Maecker, Heather, Bazan, Fernando, Huang, XiaoDong, Yue, Peng, French, Dorothy M, Eastham-Anderson, Jeffrey, Dixit, Vishva M, Ferrando, Ronald, O'Rourke, Karen

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Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins von OKAMOTO, Toru, CAMPBELL, Stephanie, MEHTA, Ninad, THIBAULT, John, COLMAN, Peter M, BARRY, Michele, HUANG, David C. S, KVANSAKUL, Marc

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In vivo Efficacy of the Bcl-2 Antagonist ABT-737 against Aggressive Myc-Driven Lymphomas von Mason, Kylie D., Vandenberg, Cassandra J., Scott, Clare L., Wei, Andrew H., Cory, Suzanne, Huang, David C. S., Roberts, Andrew W.

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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations von Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.

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A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation von Wölwer, Christina B, Pase, Luke B, Pearson, Helen B, Gödde, Nathan J, Lackovic, Kurt, Huang, David C S, Russell, Sarah M, Humbert, Patrick O

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