The storm has cleared: lessons from the CD28 superagonist TGN1412 trial von Hunig, Thomas

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Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice von Badr, Mohammad, McFleder, Rhonda L, Wu, Jingjing, Knorr, Susanne, Koprich, James B, Hünig, Thomas, Brotchie, Jonathan M, Volkmann, Jens, Lutz, Manfred B, Ip, Chi Wang

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Standardized monitoring of cytomegalovirus-specific immunity can improve risk stratification of recurrent cytomegalovirus reactivation after hematopoietic stem cell transplantation von Wagner-Drouet, Eva, Teschner, Daniel, Wolschke, Christine, Janson, Dietlinde, Schäfer-Eckart, Kerstin, Gärtner, Johannes, Mielke, Stephan, Schreder, Martin, Kobbe, Guido, Kondakci, Mustafa, Hilgendorf, Inken, von Lilienfeld-Toal, Marie, Klein, Stefan, Heidenreich, Daniela, Kreil, Sebastian, Verbeek, Mareike, Grass, Sandra, Ditschkowski, Markus, Gromke, Tanja, Koch, Martina, Lindemann, Monika, Hünig, Thomas, Schmidt, Traudel, Rascle, Anne, Guldan, Harald, Barabas, Sascha, Deml, Ludwig, Wagner, Ralf, Wolff, Daniel

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The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account von Hunig, Thomas

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CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo von Langenhorst, Daniela, Haack, Stephanie, Göb, Selina, Uri, Anna, Lühder, Fred, Vanhove, Bernard, Hünig, Thomas, Beyersdorf, Niklas

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Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model von Boivin, Valérie, Beyersdorf, Niklas, Palm, Dieter, Nikolaev, Viacheslav O, Schlipp, Angela, Müller, Justus, Schmidt, Doris, Kocoski, Vladimir, Kerkau, Thomas, Hünig, Thomas, Ertl, Georg, Lohse, Martin J, Jahns, Roland

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Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis von Beyersdorf, Niklas, Gaupp, Stefanie, Balbach, Karen, Schmidt, Jens, Toyka, Klaus V, Lin, Chia-Huey, Hanke, Thomas, Hünig, Thomas, Kerkau, Thomas, Gold, Ralf

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Foxp3+ regulatory T cells are required for recovery from severe sepsis von Kühlhorn, Franziska, Rath, Matthias, Schmoeckel, Katrin, Cziupka, Katharina, Nguyen, Huu Hung, Hildebrandt, Petra, Hünig, Thomas, Sparwasser, Tim, Huehn, Jochen, Pötschke, Christian, Bröker, Barbara M

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Foxp3+ regulatory T cells control persistence of viral CNS infection von Reuter, Dajana, Sparwasser, Tim, Hünig, Thomas, Schneider-Schaulies, Jürgen

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A novel multicolor immunostaining method using ethynyl deoxyuridine for analysis of in situ immunoproliferative response von Kitazawa, Yusuke, Ueta, Hisashi, Hünig, Thomas, Sawanobori, Yasushi, Matsuno, Kenjiro

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Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4 + Foxp3 + Regulatory T Cells von Uri, Anna, Werner, Sandra, Lühder, Fred, Hünig, Thomas, Kerkau, Thomas, Beyersdorf, Niklas

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The rise and fall of the CD 28 superagonist TGN 1412 and its return as TAB 08: a personal account von Hünig, Thomas

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Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1) von Vaeth, Martin, Gogishvili, Tea, Bopp, Tobias, Klein, Matthias, Berberich-Siebelt, Friederike, Gattenloehner, Stefan, Avots, Andris, Sparwasser, Tim, Grebe, Nadine, Schmitt, Edgar, Hünig, Thomas, Serfling, Edgar, Bodor, Josef

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Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses von Ndlovu, Hlumani, Darby, Mathew, Froelich, Monika, Horsnell, William, Lühder, Fred, Hünig, Thomas, Brombacher, Frank

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Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice von Gogishvili, Tea, Langenhorst, Daniela, Lühder, Fred, Elias, Fernando, Elflein, Karin, Dennehy, Kevin M, Gold, Ralf, Hünig, Thomas

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Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells von Langenhorst, Daniela, Gogishvili, Tea, Ribechini, Eliana, Kneitz, Susanne, McPherson, Kirsty, Lutz, Manfred B, Hünig, Thomas

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Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation von Langenhorst, Daniela, Tabares, Paula, Gulde, Tobias, Becklund, Bryan R, Berr, Susanne, Surh, Charles D, Beyersdorf, Niklas, Hünig, Thomas

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Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4 + T Cells von Bergfeld, Arne, Dasari, Prasad, Werner, Sandra, Hughes, Timothy R, Song, Wen-Chao, Hortschansky, Peter, Brakhage, Axel A, Hünig, Thomas, Zipfel, Peter F, Beyersdorf, Niklas

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Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease von Gogishvili, Tea, Dr rer nat, Lühder, Fred, Dr rer nat, Kirstein, Frank, PhD, Nieuwenhuizen, Natalie E., PhD, Goebbels, Sandra, Dr rer nat, Beer-Hammer, Sandra, Dr rer nat, Pfeffer, Klaus, MD, Reuter, Sebastian, Dr rer nat, Taube, Christian, MD, Brombacher, Frank, PhD, Hünig, Thomas, Dr rer nat

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Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists von Lühder, Fred, Huang, Yun, Dennehy, Kevin M, Guntermann, Christine, Müller, Ingrid, Winkler, Erna, Kerkau, Thomas, Ikemizu, Shinji, Davis, Simon J, Hanke, Thomas, Hünig, Thomas

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