Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity von Lv, Dongwen, Pal, Pratik, Liu, Xingui, Jia, Yannan, Thummuri, Dinesh, Zhang, Peiyi, Hu, Wanyi, Pei, Jing, Zhang, Qi, Zhou, Shuo, Khan, Sajid, Zhang, Xuan, Hua, Nan, Yang, Qingping, Arango, Sebastian, Zhang, Weizhou, Nayak, Digant, Olsen, Shaun K., Weintraub, Susan T., Hromas, Robert, Konopleva, Marina, Yuan, Yaxia, Zheng, Guangrong, Zhou, Daohong

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Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL von Nayak, Digant, Lv, Dongwen, Yuan, Yaxia, Zhang, Peiyi, Hu, Wanyi, Nayak, Anindita, Ruben, Eliza A., Lv, Zongyang, Sung, Patrick, Hromas, Robert, Zheng, Guangrong, Zhou, Daohong, Olsen, Shaun K.

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Accelerating inhibitor discovery for deubiquitinating enzymes von Chan, Wai Cheung, Liu, Xiaoxi, Magin, Robert S., Girardi, Nicholas M., Ficarro, Scott B., Hu, Wanyi, Tarazona Guzman, Maria I., Starnbach, Cara A., Felix, Alejandra, Adelmant, Guillaume, Varca, Anthony C., Hu, Bin, Bratt, Ariana S., DaSilva, Ethan, Schauer, Nathan J., Jaen Maisonet, Isabella, Dolen, Emma K., Ayala, Anthony X., Marto, Jarrod A., Buhrlage, Sara J.

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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism von Schauer, Nathan J., Liu, Xiaoxi, Magin, Robert S., Doherty, Laura M., Chan, Wai Cheung, Ficarro, Scott B., Hu, Wanyi, Roberts, Rebekka M., Iacob, Roxana E., Stolte, Björn, Giacomelli, Andrew O., Perera, Sumner, McKay, Kyle, Boswell, Sarah A., Weisberg, Ellen L., Ray, Arghya, Chauhan, Dharminder, Dhe-Paganon, Sirano, Anderson, Ken C., Griffin, James D., Li, Jianing, Hahn, William C., Sorger, Peter K., Engen, John R., Stegmaier, Kimberly, Marto, Jarrod A., Buhrlage, Sara J.

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BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers von Khan, Sajid, Wiegand, Janet, Zhang, Peiyi, Hu, Wanyi, Thummuri, Dinesh, Budamagunta, Vivekananda, Hua, Nan, Jin, Lingtao, Allegra, Carmen J, Kopetz, Scott E, Zajac-Kaye, Maria, Kaye, Frederic J, Zheng, Guangrong, Zhou, Daohong

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Targeted degradation of specific TEAD paralogs by small molecule degraders von Chen, Hui, Gridnev, Artem, Schlamowitz, Netanya, Hu, Wanyi, Dey, Kuntala, Zheng, Guangrong, Misra, Jyoti R.

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High-resolution genetic mapping and identification of candidate genes for the wheat stem rust resistance gene Sr8155B1 von Wang, Jian, Li, Hongyu, Shen, Tao, Lyu, Shikai, ur Rehman, Shams, Li, Hongna, Wang, Guiping, Xu, Binyang, Wang, Qing, Hu, Wanyi, Li, Kairong, Bai, Shengsheng, Ma, Jian, Yu, Haitao, Rouse, Matthew N., Chen, Shisheng

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Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity von Zhang, Xuan, Thummuri, Dinesh, Liu, Xingui, Hu, Wanyi, Zhang, Peiyi, Khan, Sajid, Yuan, Yaxia, Zhou, Daohong, Zheng, Guangrong

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Discovery of PROTAC BCL-X-L degraders as potent anticancer agents with low on-target platelet toxicity von Zhang, Xuan, Thummuri, Dinesh, Liu, Xingui, Hu, Wanyi, Zhang, Peiyi, Khan, Sajid, Yuan, Yaxia, Zhou, Daohong, Zheng, Guangrong

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Abstract 1209 Structural And Biochemical Studies Of Proteolysis-Targeting Chimera (PROTAC) Against Oncogenic Anti-Apoptotic Proteins, BCL-xl And Bcl-2 von Nayak, Digant, Lyu, Dongwen, Hu, Wanyi, Zheng, Guangrong, Zhao, Daohong, Olsen, Shaun

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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development von Donovan, Katherine A., Ferguson, Fleur M., Bushman, Jonathan W., Eleuteri, Nicholas A., Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D., Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P., Ghobrial, Irene M., Ma, Michelle W., Che, Jianwei, Buhrlage, Sara J., Sim, Taebo, Gray, Nathanael S., Fischer, Eric S.

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Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7 von Lamberto, Ilaria, Liu, Xiaoxi, Seo, Hyuk-Soo, Schauer, Nathan J., Iacob, Roxana E., Hu, Wanyi, Das, Deepika, Mikhailova, Tatiana, Weisberg, Ellen L., Engen, John R., Anderson, Kenneth C., Chauhan, Dharminder, Dhe-Paganon, Sirano, Buhrlage, Sara J.

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Discovery of a Novel BCL-X-L PROTAC Degrader with Enhanced BCL-2 Inhibition von Pal, Pratik, Thummuri, Dinesh, Lv, Dongwen, Liu, Xingui, Zhang, Peiyi, Hu, Wanyi, Poddar, Saikat K., Hua, Nan, Khan, Sajid, Yuan, Yaxia, Zhang, Xuan, Zhou, Daohong, Zheng, Guangrong

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Piperlongumine conjugates induce targeted protein degradation von Pei, Jing, Xiao, Yufeng, Liu, Xingui, Hu, Wanyi, Sobh, Amin, Yuan, Yaxia, Zhou, Shuo, Hua, Nan, Mackintosh, Samuel G., Zhang, Xuan, Basso, Kari B., Kamat, Manasi, Yang, Qingping, Licht, Jonathan D., Zheng, Guangrong, Zhou, Daohong, Lv, Dongwen

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Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors von Bushman, Jonathan W., Donovan, Katherine A., Schauer, Nathan J., Liu, Xiaoxi, Hu, Wanyi, Varca, Anthony C., Buhrlage, Sara J., Fischer, Eric S.

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Enriched Signalling Pathways in Venetoclax-Relapsed Chronic Lymphocytic Leukemia (CLL) Cells and Targeting Using a Protac-Based Bcl-2/Bcl-Xl Degrader von Diaz Rohena, Daisy, Peris Cuesta, Arnau, Slawin, Bailey, Ravikrishnan, Janani, Liu, Chaomei, Williams, Charmelle, Hu, Wanyi, Zhang, Peiyi, Thompson, Philip, Wierda, William G., Jain, Nitin, Shukla, Sachet, Zheng, Guangrong, Zhou, Daohong, Woyach, Jennifer A., Sampath, Deepa

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Targeting Venetoclax Resistant CLL Using a Protac-Based BCL-2/BCL-XL Degrader von Diaz Rohena, Daisy, Slawin, Bailey, Ravikrishnan, Janani, Liu, Chaomei, Hu, Wanyi, Zhang, Peiyi, Thompson, Philip A., Wierda, William G., Jain, Nitin, Zheng, Guangrong, Zhou, Daohong, Woyach, Jennifer A., Sampath, Deepa

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Design, Synthesis, and Evaluation of BCL‐2 Targeting PROTACs von Bricelj, Aleša, Dora Ng, Yuen Lam, Gobec, Martina, Kuchta, Robert, Hu, Wanyi, Javornik, Špela, Rožič, Miha, Gütschow, Michael, Zheng, Guangrong, Krönke, Jan, Steinebach, Christian, Sosič, Izidor

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Discovery of a Novel BCL‑XL PROTAC Degrader with Enhanced BCL‑2 Inhibition von Pal, Pratik, Thummuri, Dinesh, Lv, Dongwen, Liu, Xingui, Zhang, Peiyi, Hu, Wanyi, Poddar, Saikat K, Hua, Nan, Khan, Sajid, Yuan, Yaxia, Zhang, Xuan, Zhou, Daohong, Zheng, Guangrong

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Abstract B009: A liver-tropic BCL-xL PROTAC effectively clears senescent hepatocytes and prevents NASH-driven HCC in mice von Yang, Yang, Jn-Simon, Natacha, Hu, Wanyi, Zhang, Peiyi, Zheng, Guangrong, Pi, Liya, He, Yonghan, Zhou, Daohong

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