Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies von Chowdhury, Sarwat, Sripathy, Smitha, Webster, Alyssa A., Park, Angela, Lao, Uyen, Hsu, Joanne H., Loe, Taylor, Bedalov, Antonio, Simon, Julian A.

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Chromosome-specific DNA repeats: rapid identification in silico and validation using fluorescence in situ hybridization von Hsu, Joanne H, Zeng, Hui, Lemke, Kalistyn H, Polyzos, Aris A, Weier, Jingly F, Wang, Mei, Lawin-O'Brien, Anna R, Weier, Heinz-Ulrich G, O'Brien, Benjamin

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Multi-Color Spectral Transcript Analysis (SPECTRA) for Phenotypic Characterization of Tumor Cells von Hsu, Joanne H, Weier, Jingly F, Weier, Heinz-Ulrich G, Ito, Yuko

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Schrödinger's microbes: Tools for distinguishing the living from the dead in microbial ecosystems von Emerson, Joanne B, Adams, Rachel I, Román, Clarisse M Betancourt, Brooks, Brandon, Coil, David A, Dahlhausen, Katherine, Ganz, Holly H, Hartmann, Erica M, Hsu, Tiffany, Justice, Nicholas B, Paulino-Lima, Ivan G, Luongo, Julia C, Lymperopoulou, Despoina S, Gomez-Silvan, Cinta, Rothschild-Mancinelli, Brooke, Balk, Melike, Huttenhower, Curtis, Nocker, Andreas, Vaishampayan, Parag, Rothschild, Lynn J

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Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome von Hsu, Yu-Han H., Astley, Christina M., Cole, Joanne B., Vedantam, Sailaja, Mercader, Josep M., Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K., Gonzalez, Clicerio, Gonzalez, Maria E., Esko, Tonu, Hirschhorn, Joel N.

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Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge von Monitto, Constance L., Hsu, Aaron, Gao, Shuna, Vozzo, Paul T., Park, Paul S., Roter, Deborah, Yenokyan, Gayane, White, Elizabeth D., Kattail, Deepa, Edgeworth, Amy E., Vasquenza, Kelly J., Atwater, Sara E., Shay, Joanne E., George, Jessica A., Vickers, Barbara A., Kost-Byerly, Sabine, Lee, Benjamin H., Yaster, Myron

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Racial and ethnic disparities in untreated patients with hepatitis C virus-related hepatocellular carcinoma but not in those with sustained virologic response von Park, Jung Eun, Nguyen, Vy H, Tsai, Pei-Chien, Toyoda, Hidenori, Leong, Jennifer, Guy, Jennifer E, Yeh, Ming-Lun, Huang, Chung-Feng, Yasuda, Satoshi, Abe, Hiroshi, Hsu, Yao-Chun, Tseng, Cheng-Hao, Liu, Joanne, Chen, Yao-Li, Lin, Ping-Yi, Jun, Dae Won, Yoshimaru, Yoko, Ogawa, Eiichi, Ishigami, Masatoshi, Enomoto, Masaru, Tamori, Akihiro, Uojima, Haruki, Wang, Xiao Zhong, Xu, Qiang, Takahashi, Hirokazu, Eguchi, Yuichiro, Inoue, Kaori, Huang, Daniel Q, Zhao, Wen Jing, Chuang, Wan-Long, Dai, Chia-Yen, Huang, Jee-Fu, Barnett, Scott, Maeda, Mayumi, Cheung, Ramsey, Landis, Charles, Tanaka, Yasuhito, Roberts, Lewis R, Schwartz, Myron E, Kumada, Takashi, Yu, Ming-Lung, Nguyen, Mindie H

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Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production von Lau, Anthony, Avery, Danielle T, Jackson, Katherine, Lenthall, Helen, Volpi, Stefano, Brigden, Henry, Russell, Amanda J, Bier, Julia, Reed, Joanne H, Smart, Joanne M, Cole, Theresa, Choo, Sharon, Gray, Paul E, Berglund, Lucinda J, Hsu, Peter, Wong, Melanie, O'Sullivan, Michael, Boztug, Kaan, Meyts, Isabelle, Uzel, Gulbu, Notarangelo, Luigi D, Brink, Robert, Goodnow, Christopher C, Tangye, Stuart G, Deenick, Elissa K

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Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group von Puzanov, I, Diab, A, Abdallah, K, Bingham, 3rd, C O, Brogdon, C, Dadu, R, Hamad, L, Kim, S, Lacouture, M E, LeBoeuf, N R, Lenihan, D, Onofrei, C, Shannon, V, Sharma, R, Silk, A W, Skondra, D, Suarez-Almazor, M E, Wang, Y, Wiley, K, Kaufman, H L, Ernstoff, M S

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A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF von Chuang, Ling-Shiang, Villaverde, Nicole, Hui, Ken Y, Mortha, Arthur, Rahman, Adeeb, Levine, Adam P, Haritunians, Talin, Evelyn Ng, Sok Meng, Zhang, Wei, Hsu, Nai-Yun, Facey, Jody-Ann, Luong, Tramy, Fernandez-Hernandez, Heriberto, Li, Dalin, Rivas, Manuel, Schiff, Elena R, Gusev, Alexander, Schumm, L. Phillip, Bowen, Beatrice M, Sharma, Yashoda, Ning, Kaida, Remark, Romain, Gnjatic, Sacha, Legnani, Peter, George, James, Sands, Bruce E, Stempak, Joanne M, Datta, Lisa W, Lipka, Seth, Katz, Seymour, Cheifetz, Adam S, Barzilai, Nir, Pontikos, Nikolas, Abraham, Clara, Dubinsky, Marla J, Targan, Stephan, Taylor, Kent, Rotter, Jerome I, Scherl, Ellen J, Desnick, Robert J, Abreu, Maria T, Zhao, Hongyu, Atzmon, Gil, Pe’er, Itsik, Kugathasan, Subra, Hakonarson, Hakon, McCauley, Jacob L, Lencz, Todd, Darvasi, Ariel, Plagnol, Vincent, Silverberg, Mark S, Muise, Aleixo M, Brant, Steven R, Daly, Mark J, Segal, Anthony W, Duerr, Richard H, Merad, Miriam, McGovern, Dermot P.B, Peter, Inga, Cho, Judy H

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Temperature-Dependent Galleria mellonella Mortality as a Result of Yersinia entomophaga Infection von Hurst, Mark R H, Beattie, Amy K, Jones, Sandra A, Hsu, Pei-Chun, Calder, Joanne, van Koten, Chikako

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Cancer Chemotherapy Accelerates the Loss of Clonal Diversity in Hematopoietic Stem Cells and Promotes the Convergent Evolution of Therapy-Related Clonal Hematopoiesis von Uryu, Hidetaka, Saeki, Koichi, Nangalia, Jyoti, Spencer Chapman, Michael, Zhao, Li, Hsu, Joanne I., Bueso-Ramos, Carlos E., Chen, Shujuan, Yang, Hui, Kantarjian, Hagop, DiNardo, Courtney D., Daver, Naval, Colla, Simona, Ganan-Gomez, Irene, Zhang, Jianhua, Song, Xingzhi, Thompson, Erika, Tang, Hongli, Orlowski, Robert Z., Champlin, Richard E, Qazilbash, Muzaffar H, Shpall, Elizabeth J, Garcia-Manero, Guillermo, Haeno, Hiroshi, Takahashi, Koichi, Futreal, Andrew

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816 RACIAL AND ETHNIC DISPARITIES IN DIRECT-ACTING ANTIVIRAL (DAA) TREATMENT AND SURVIVAL OUTCOMES FOR TREATED/SVR (SUSTAINED VIROLOGIC RESPONSE) AND UNTREATED/NON-SVR PATIENTS WIT... von Park, Jung Eun, Nguyen, Vy H., Tsai, Pei-Chien, Toyoda, Hidenori, Leong, Jennifer, Guy, Jennifer, Yeh, Ming-Lun, Huang, Chung-Feng, Yasuda, Satoshi, Abe, Hiroshi, Hsu, Yao-Chun, Tseng, Cheng-Hao, Liu, Joanne, Chen, Yao-Li, Lin, Ping-Yi, Jun, Dae Won, Yoshimaru, Yoko, Ogawa, Eiichi, Ishigami, Masatoshi, Enomoto, Masaru, Tamori, Akihiro, Uojima, Haruki, Wang, Xiao Zhong, Xu, Qiang, Takahashi, Hirokazu, Eguchi, Yuichiro, Inoue, Kaori, Huang, Daniel, Zhao, Wen Jing, Chuang, Wan-Long, Dai, Chia-Yen, Huang, Jee-Fu, Cheung, Ramsey, Landis, Charles, Tanaka, Yasuhito, Roberts, Lewis R., Schwartz, Myron, Kumada, Takashi, Yu, Ming-Lung, Nguyen, Mindie H.

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Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production von Lau, Anthony, Avery, Danielle T, Jackson, Katherine, Lenthall, Helen, Volpi, Stefano, Brigden, Henry, Russell, Amanda J, Bier, Julia, Reed, Joanne H, Smart, Joanne M, Cole, Theresa, Choo, Sharon, Gray, Paul E, Berglund, Lucinda J, Hsu, Peter, Wong, Melanie, O'Sullivan, Michael, Boztug, Kaan, Meyts, Isabelle, Uzel, Gulbu, Notarangelo, Luigi D, Brink, Robert, Goodnow, Christopher C, Tangye, Stuart G, Deenick, Elissa K

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A novel modality of BAFF-specific inhibitor AMG623 peptibody reduces B-cell number and improves outcomes in murine models of autoimmune disease von HSU, H, KHARE, S. D, XIONG, F, BOONE, T, ZACK, D. J, LEE, F, MINER, K, HU, Y.-L, STOLINA, M, HAWKINS, N, CHEN, Q, HO, S. J, MIN, H

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Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus von Ma, Christopher, Ma, Christopher, Schoepfer, Alain M., Schoepfer, Alain M., Safroneeva, Ekaterina, Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina

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The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL von De Braekeleer, Etienne, Hsu, Joanne, Hervieu, Celine, Tzelepis, Konstantinos, Indraccolo, Stefano, Warren, Alan J., Jeremias, Irmela, Antoran, David Fernandez, Jones, Phil H, Goodell, Margaret A., Vassiliou, George S.

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Sa1396: ANTIVIRAL THERAPY IMPROVES SURVIVAL IN VIRAL-ASSOCIATED HEPATOCELLULAR CARCINOMA AFTER LIVER RESECTION BUT IS SEVERELY UNDERUTILIZED von Huang, Daniel, Kamal, Rubayet, Tsai, Pei-Chien, Toyoda, Hidenori, Yeh, Ming-Lun, Yasuda, Satoshi, Leong, Jennifer, Hoang, Joseph, Maeda, Mayumi, Huang, Chung-Feng, Jun, Dae Won, Bonham, Andrew, Ogawa, Eiichi, Uojima, Haruki, Abe, Hiroshi, Hsu, Yao-Chun, Tseng, Cheng-Hao, Liu, Joanne, Landis, Charles, Dai, Chia-Yen, Huang, Jee-Fu, Chuang, Wan-Long, Schwartz, Myron, Dan, Yock Young, Esquivel, Carlos O., Yu, Ming-Lung, Nguyen, Mindie H., Suzuki, Takanori, Tanaka, Yasuhito

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Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry von Graff, Mariaelisa, Young, Kristin L., Marouli, Eirini, Fine, Rebecca S., Lim, Elise, Buchanan, Victoria, Rand, Kristin, Wojczynski, Mary K., Yanek, Lisa R., Aldrich, Melinda C., Ambrosone, Christine B., Atwood, Larry, Bandera, Elisa V., Berndt, Sonja I., Bernstein, Leslie, Bowden, Donald W., Burke, Gregory, Cai, Qiuyin, Carlson, Chris, Casey, Graham, Chanock, Stephen J., Chen, Guanjie, Chen, Minhui, Conti, David V., Cooper, Richard S., Cushman, Mary, Dimitrov, Latchezar, Evans, Michele K., Freedman, Barry I., Gillanders, Elizabeth M., Gottesman, Omri, Henderson, Brian E., Hernandez, Dena G., Hsing, Ann W., Hsu, Yu-Han H., Huo, Dezheng, Irvin, Marguerite R., John, Esther M., Johnson, Karen C., Jordan, Joanne M., Kabagambe, Edmond K., Keating, Brendan J., Kittles, Rick A., Leonard, Hampton, Lettre, Guillaume, Li, Yun, Li, Jin, Liu, Yongmei, Liu, Youfang, Liu, Simin, Lohman, Kurt, Maixner, William, McKnight, Barbara, Meng, Yan, Monda, Keri L., Moore, Jason H., Murphy, Adam B., Nalls, Mike A., Nathanson, Katherine L., Neuhouser, Marian L., Nyante, Sarah, Ochs-Balcom, Heather, Ogundiran, Temidayo O., Ogunniyi, Adesola, Padhukasahasram, Badri, Pettaway, Curtis A., Peyser, Patricia A., Rao, D.C., Rasmussen-Torvik, Laura J., Reiner, Alex P., Rhie, Suhn K., Rodriguez-Gil, Jorge L., Schwartz, Ann G., Shriner, Daniel A., Siscovick, David S., Smith, Shad, Spitz, Margaret, Stevens, Victoria L., Stram, Alex, Strom, Sara S., Sucheston, Lara, Sun, Yan V., Tajuddin, Salman M., Tayo, Bamidele O., Thun, Michael J., Vaidya, Dhananjay, Vedantam, Sailaja, Vitolins, Mara, Wang, Zhaoming, Wassertheil-Smoller, Sylvia, Weir, David R., Wilson, James G., Wrensch, Margaret, Wu, Xifeng, Zakai, Neil, Zonderman, Alan B., Psaty, Bruce M., Borecki, Ingrid B., Liu, Ching-Ti, North, Kari E.

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P1330: CYTOREDUCTIVE CHEMOTHERAPY COULD ACCELERATE THE LOSS OF CLONAL DIVERSITY IN HEMATOPOIETIC STEM CELLS AND PROMOTES THE CONVERGENT EVOLUTION OF THERAPY‐RELATED CLONAL HEMATOPO... von Uryu, Hidetaka, Saeki, Koichi, Nangalia, Jyoti, Chapman, Michael, Zhao, LI, Hsu, Joanne, Bueso‐Ramos, Carlos, Chen, Shujuan, Yang, Hui, Dinardo, Courtney, Daver, Naval, Colla, Simona, Ganan‐Gomez, Irene, Zhang, Jianhua, Song, Xingzhi, Thompson, Erika, Tang, Hongli, Orlowski, Robert Z, Champlin, Richard E., Qazilbash, Muzaffar H., Shpall, Elizabeth J., Futreal, Andrew, Garcia‐Manero, Guillermo, Haeno, Hiroshi, Takahashi, Koichi

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