Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner von Xie, Huafeng, Xu, Jian, Hsu, Jessie H., Nguyen, Minh, Fujiwara, Yuko, Peng, Cong, Orkin, Stuart H.

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Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial von Ascierto, Paolo A, McArthur, Grant A, Dréno, Brigitte, Atkinson, Victoria, Liszkay, Gabrielle, Di Giacomo, Anna Maria, Mandalà, Mario, Demidov, Lev, Stroyakovskiy, Daniil, Thomas, Luc, de la Cruz-Merino, Luis, Dutriaux, Caroline, Garbe, Claus, Yan, Yibing, Wongchenko, Matthew, Chang, Ilsung, Hsu, Jessie J, Koralek, Daniel O, Rooney, Isabelle, Ribas, Antoni, Larkin, James

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex von Hsu, Jessie Hao-Ru, Rasmusson, Timothy, Robinson, James, Pachl, Fiona, Read, Jon, Kawatkar, Sameer, O’ Donovan, Daniel H., Bagal, Sharan, Code, Erin, Rawlins, Philip, Argyrou, Argyrides, Tomlinson, Ronald, Gao, Ning, Zhu, Xiahui, Chiarparin, Elisabetta, Jacques, Kelly, Shen, Minhui, Woods, Haley, Bednarski, Emma, Wilson, David M., Drew, Lisa, Castaldi, M. Paola, Fawell, Stephen, Bloecher, Andrew

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Modeling initiation of Ewing sarcoma in human neural crest cells von von Levetzow, Cornelia, Jiang, Xiaohua, Gwye, Ynnez, von Levetzow, Gregor, Hung, Long, Cooper, Aaron, Hsu, Jessie Hao-Ru, Lawlor, Elizabeth R

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Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice von Özcan, Ezgi, Yu, Kristie B., Dinh, Lyna, Lum, Gregory R., Lau, Katie, Hsu, Jessie, Arino, Mariana, Paramo, Jorge, Lopez-Romero, Arlene, Hsiao, Elaine Y.

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Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF -Mutant Melanoma von Ribas, Antoni, Daud, Adil, Pavlick, Anna C, Gonzalez, Rene, Lewis, Karl D, Hamid, Omid, Gajewski, Thomas F, Puzanov, Igor, Wongchenko, Matthew, Rooney, Isabelle, Hsu, Jessie J, Yan, Yibing, Park, Erica, McArthur, Grant A

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Outcome-Driven Cluster Analysis with Application to Microarray Data von Hsu, Jessie J, Finkelstein, Dianne M, Schoenfeld, David A

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase von Bagal, Sharan K, Gregson, Clare, O’ Donovan, Daniel H, Pike, Kurt G, Bloecher, Andrew, Barton, Peter, Borodovsky, Alexandra, Code, Erin, Fillery, Shaun M, Hsu, Jessie Hao-Ru, Kawatkar, Sameer P, Li, Chengzhi, Longmire, David, Nai, Youfeng, Nash, Samuel C, Pike, Andrew, Robinson, James, Read, Jon A, Rawlins, Phillip B, Shen, Minhui, Tang, Jia, Wang, Peng, Woods, Haley, Williamson, Beth

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Phase III Trial Comparing Concurrent Biochemotherapy With Cisplatin, Vinblastine, Dacarbazine, Interleukin-2, and Interferon Alfa-2b With Cisplatin, Vinblastine, and Dacarbazine Al... von ATKINS, Michael B, HSU, Jessie, LEE, Sandra, COHEN, Gary I, FLAHERTY, Lawrence E, SOSMAN, Jeffrey A, SONDAK, Vernon K, KIRKWOOD, John M

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B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-c... von SNUDERL, Matija, KOLMAN, Olga K, ABRAMSON, Jeremy S, HOCHBERG, Ephraim P, LEE, Hang, LEE, Alfred I, TOOMEY, Christiana E, SOHANI, Aliyah R, CHEN, Yi-Bin, HSU, Jessie J, ACKERMAN, Adam M, DAL CIN, Paola, FERRY, Judith A, LEE HARRIS, Nancy, HASSERJIAN, Robert P, ZUKERBERG, Lawrence R

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Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study von de la Cruz-Merino, Luis, Di Guardo, Lorenza, Grob, Jean-Jacques, Venosa, Alfredo, Larkin, James, McArthur, Grant A, Ribas, Antoni, Ascierto, Paolo A, Evans, Jeffrey T R, Gomez-Escobar, Antonio, Barteselli, Giulio, Eng, Susan, Hsu, Jessie J, Uyei, Anne, Dréno, Brigitte

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A Phase II Randomized Trial (GO27827) of First‐Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer von Bendell, Johanna C., Hochster, Howard, Hart, Lowell L., Firdaus, Irfan, Mace, Joseph R., McFarlane, Joshua J., Kozloff, Mark, Catenacci, Daniel, Hsu, Jessie J., Hack, Stephen P., Shames, David S., Phan, See‐Chun, Koeppen, Hartmut, Cohn, Allen L.

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase von O' Donovan, Daniel H., Gregson, Clare, Packer, Martin J., Greenwood, Ryan, Pike, Kurt G., Kawatkar, Sameer, Bloecher, Andrew, Robinson, James, Read, Jon, Code, Erin, Hsu, Jessie Hao-Ru, Shen, Minhui, Woods, Haley, Barton, Peter, Fillery, Shaun, Williamson, Beth, Rawlins, Philip B., Bagal, Sharan K.

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BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression von Douglas, Dorothea, Hsu, Jessie Hao-Ru, Hung, Long, Cooper, Aaron, Abdueva, Diana, van Doorninck, John, Peng, Grace, Shimada, Hiro, Triche, Timothy J, Lawlor, Elizabeth R

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Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma von Green, Adam L, Ramkissoon, Shakti H, McCauley, Dilara, Jones, Kristen, Perry, Jennifer A, Hsu, Jessie Hao-Ru, Ramkissoon, Lori A, Maire, Cecile L, Hubbell-Engler, Benjamin, Knoff, David S, Shacham, Sharon, Ligon, Keith L, Kung, Andrew L

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PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer von Hsu, Jessie Hao-Ru, Hubbell-Engler, Benjamin, Adelmant, Guillaume, Huang, Jialiang, Joyce, Cailin E, Vazquez, Francisca, Weir, Barbara A, Montgomery, Philip, Tsherniak, Aviad, Giacomelli, Andrew O, Perry, Jennifer A, Trowbridge, Jennifer, Fujiwara, Yuko, Cowley, Glenn S, Xie, Huafeng, Kim, Woojin, Novina, Carl D, Hahn, William C, Marto, Jarrod A, Orkin, Stuart H

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Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients with BRAF V600 -mutated Metastatic Melanoma von Yan, Yibing, Wongchenko, Matthew J, Robert, Caroline, Larkin, James, Ascierto, Paolo A, Dréno, Brigitte, Maio, Michele, Garbe, Claus, Chapman, Paul B, Sosman, Jeffrey A, Shi, Zhen, Koeppen, Hartmut, Hsu, Jessie J, Chang, Ilsung, Caro, Ivor, Rooney, Isabelle, McArthur, Grant A, Ribas, Antoni

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Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program von Morley, Roland, Cardenas, Alison, Hawkins, Peter, Suzuki, Yasuyo, Paton, Virginia, Phan, See-Chun, Merchant, Mark, Hsu, Jessie, Yu, Wei, Xia, Qi, Koralek, Daniel, Luhn, Patricia, Aldairy, Wassim

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Cobimetinib combined with vemurafenib in advanced BRAFV600 -mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial von Ascierto, Paolo A, MD, McArthur, Grant A, Prof, Dréno, Brigitte, Prof, Atkinson, Victoria, MD, Liszkay, Gabrielle, MD, Di Giacomo, Anna Maria, MD, Mandalà, Mario, MD, Demidov, Lev, MD, Stroyakovskiy, Daniil, MD, Thomas, Luc, Prof, de la Cruz-Merino, Luis, MD, Dutriaux, Caroline, MD, Garbe, Claus, Prof, Yan, Yibing, PhD, Wongchenko, Matthew, BS, Chang, Ilsung, PhD, Hsu, Jessie J, PhD, Koralek, Daniel O, PhD, Rooney, Isabelle, MBChB, Ribas, Antoni, Prof, Larkin, James, FRCP

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Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group von COOPER, Aaron, VAN DOORNINCK, John, TRICHE, Timothy J, SPOSTO, Richard, LAWLOR, Elizabeth R, LINGYUN JI, RUSSELL, Darren, LADANYI, Marc, SHIMADA, Hiroyuki, KRAILO, Mark, WOMER, Richard B, HSU, Jessie Hao-Ru, THOMAS, Dafydd

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