Characterization of a New Class of Potent Inhibitors of the Voltage-Gated Sodium Channel Nav1.7 von Williams, Brande S, Felix, John P, Priest, Birgit T, Brochu, Richard M, Dai, Kefei, Hoyt, Scott B, London, Clare, Tang, Yui S, Duffy, Joseph L, Parsons, William H, Kaczorowski, Gregory J, Garcia, Maria L

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Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML von Bennett, Joshua, Ishikawa, Chiharu, Agarwal, Puneet, Yeung, Jennifer, Sampson, Avery, Uible, Emma, Vick, Eric, Bolanos, Lyndsey C., Hueneman, Kathleen, Wunderlich, Mark, Kolt, Amal, Choi, Kwangmin, Volk, Andrew, Greis, Kenneth D., Rosenbaum, Jan, Hoyt, Scott B., Thomas, Craig J., Starczynowski, Daniel T.

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Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain von Hoyt, Scott B., London, Clare, Gorin, David, Wyvratt, Matthew J., Fisher, Michael H., Abbadie, Catherine, Felix, John P., Garcia, Maria L., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, MacIntyre, D. Euan, Martin, William J., Priest, Birgit T., Ritter, Amy, Smith, McHardy M., Warren, Vivien A., Williams, Brande S., Kaczorowski, Gregory J., Parsons, William H.

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Targeting AML-associated FLT3 mutations with a type I kinase inhibitor von Jones, LaQuita M., Melgar, Katelyn, Bolanos, Lyndsey, Hueneman, Kathleen, Walker, Morgan M., Jiang, Jian-Kang, Wilson, Kelli M., Zhang, Xiaohu, Shen, Jian, Jiang, Fan, Sutter, Patrick, Wang, Amy, Xu, Xin, Tawa, Gregory J., Hoyt, Scott B., Wunderlich, Mark, O'Brien, Eric, Perentesis, John P., Starczynowski, Daniel T., Thomas, Craig J.

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A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain von McGowan, Erin, Hoyt, Scott B, Li, Xiaohua, Lyons, Kathryn A, Abbadie, Catherine

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Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia von Hoyt, Scott B., Finocchio, Chris J., Croll, Elizabeth, Tawa, Gregory J., Li, Huixu, Ma, Li, Li, Kaikai, Liu, Li, Li, Ranran, Zhang, Xiaohu, Wilson, Kelli, Xu, Xin, Shah, Pranav, Williams, Jordan, Fang, Yuhong, Bolanos, Lyndsey C., Gracia-Maldonado, Gabriel, Kolt, Amal, Robinson, Christina, Free, Jessica, Edmondson, Elijah F., Difilippantonio, Simone, Jones, LaQuita M., Culver-Cochran, Ashley E., Rosenbaum, Jan S., Starczynowski, Daniel T., Thomas, Craig J.

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Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension von Hoyt, Scott B., Taylor, Jerry, London, Clare, Ali, Amjad, Ujjainwalla, Feroze, Tata, Jim, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Clemas, Joe, Zhou, Gaochao, MacNeil, Douglas, Duffy, Ruth, Xiong, Yusheng

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Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker von Abbadie, Catherine, McManus, Owen B, Sun, Shu-Yu, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Herrington, James B, Kaczorowski, Gregory J, Smith, McHardy M, Swensen, Andrew M, Warren, Vivien A, Williams, Brande, Arneric, Stephen P, Eduljee, Cyrus, Snutch, Terrance P, Tringham, Elizabeth W, Jochnowitz, Nina, Liang, Annie, Euan MacIntyre, D, McGowan, Erin, Mistry, Shruti, White, Valerie V, Hoyt, Scott B, London, Clare, Lyons, Kathryn A, Bunting, Patricia B, Volksdorf, Sylvia, Duffy, Joseph L

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A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain von McGowan, Erin, Hoyt, Scott B., Li, Xiaohua, Lyons, Kathryn A., Abbadie, Catherine

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Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels von Swensen, Andrew M, Herrington, James, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Ratliff, Kevin S, Smith, McHardy M, Warren, Vivien A, Arneric, Stephen P, Eduljee, Cyrus, Parker, David, Snutch, Terrance P, Hoyt, Scott B, London, Clare, Duffy, Joseph L, Kaczorowski, Gregory J, McManus, Owen B

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Imidazopyridyl compounds as aldosterone synthase inhibitors von Whitehead, Brent R., Lo, Michael M.-C., Ali, Amjad, Park, Min K., Hoyt, Scott B., Xiong, Yusheng, Cai, Jiaqiang, Carswell, Emma, Cooke, Andrew, MacLean, John, Ratcliffe, Paul, Robinson, John, Bennett, D. Jonathan, Clemas, Joseph A., Wisniewski, Tom, Struthers, Mary, Cully, Doris, MacNeil, Douglas J.

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Investigation of a Dialkylation Approach for Enantioselective Construction of Vicinal Quaternary Stereocenters von Hoyt, Scott B, Overman, Larry E

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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension von Petrilli, Whitney L, Hoyt, Scott B, London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J, Duffy, Ruth, Tata, James R, Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng

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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain von Hoyt, Scott B., London, Clare, Abbadie, Catherine, Felix, John P., Garcia, Maria L., Jochnowitz, Nina, Karanam, Bindhu V., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, Priest, Birgit T., Smith, McHardy M., Warren, Vivien A., Thomas-Fowlkes, Brande S., Kaczorowski, Gregory J., Duffy, Joseph L.

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Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain von Hoyt, Scott B, London, Clare, Gorin, David, Wyvratt, Matthew J, Fisher, Michael H, Abbadie, Catherine, Felix, John P, Garcia, Maria L, Li, Xiaohua, Lyons, Kathryn A, McGowan, Erin, MacIntyre, D Euan, Martin, William J, Priest, Birgit T, Ritter, Amy, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Kaczorowski, Gregory J, Parsons, William H

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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys von Hoyt, Scott B, Petrilli, Whitney, London, Clare, Liang, Gui-Bai, Tata, Jim, Hu, Qingzhong, Yin, Lina, van Koppen, Chris J, Hartmann, Rolf W, Struthers, Mary, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Xiong, Yusheng

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Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys von Hoyt, Scott B, Park, Min K, London, Clare, Xiong, Yusheng, Tata, Jim, Bennett, D. Jonathan, Cooke, Andrew, Cai, Jiaqiang, Carswell, Emma, Robinson, John, MacLean, John, Brown, Lindsay, Belshaw, Simone, Clarkson, Thomas R, Liu, Kun, Liang, Gui-Bai, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Kuethe, Jeff, Rivera, Nelo, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Ali, Amjad

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Benzazepinone Nav1.7 blockers : Potential treatments for neuropathic pain von HOYT, Scott B, LONDON, Clare, KARANAM, Bindhu V, XIAOHUA LI, LYONS, Kathryn A, MCGOWAN, Erin, EUAN MACINTYRE, D, MARTIN, William J, PRIEST, Birgit T, SMITH, Mchardy M, TSCHIRRET-GUTH, Richard, WARREN, Vivien A, OK, Hyun, WILLIAMS, Brande S, KACZOROWSKI, Gregory J, PARSONS, William H, GONZALEZ, Edward, DUFFY, Joseph L, ABBADIE, Catherine, DEAN, Brian, FELIX, John P, GARCIA, Maria L, JOCHNOWITZ, Nina

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Imidazopyridines : A novel class of hNav1.7 channel blockers von LONDON, Clare, HOYT, Scott B, LYONS, Kathryn A, XIAOHUA LI, KARANAM, Bindhu V, JOCHNOWITZ, Nina, GARCIA, Maria L, FELIX, John P, DEAN, Brian, ABBADIE, Catherine, KACZOROWSKI, Gregory J, DUFFY, Joseph L, PARSONS, William H, WILLIAMS, Brande S, WARREN, Vivien A, TSCHIRRET-GUTH, Richard, SMITH, Mchardy M, PRIEST, Birgit T, MCGOWAN, Erin, MARTIN, William J

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Inhibition of Both IRAK1 and IRAK4 Is Required for Complete Suppression of NF-Kb Signaling across Multiple Receptor-Mediated Pathways in MDS and AML von Rosenbaum, Jan S, Hoyt, Scott B., Kolt, Amal S., Luedtke, Daniel A, Thomas, Craig J., Starczynowski, Daniel T.

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