The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism von Hoxhaj, Gerta, Manning, Brendan D.

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Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase von Hoxhaj, Gerta, Ben-Sahra, Issam, Lockwood, Sophie E, Timson, Rebecca C, Byles, Vanessa, Henning, Graham T, Gao, Peng, Selfors, Laura M, Asara, John M, Manning, Brendan D

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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle von Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J. H., Asara, John M., Manning, Brendan D.

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome von Menon, Suchithra, Dibble, Christian C., Talbott, George, Hoxhaj, Gerta, Valvezan, Alexander J., Takahashi, Hidenori, Cantley, Lewis C., Manning, Brendan D.

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Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex von Howell, Jessica J., Hellberg, Kristina, Turner, Marc, Talbott, George, Kolar, Matthew J., Ross, Debbie S., Hoxhaj, Gerta, Saghatelian, Alan, Shaw, Reuben J., Manning, Brendan D.

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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway von Soflaee, Mona Hoseini, Kesavan, Rushendhiran, Sahu, Umakant, Tasdogan, Alpaslan, Villa, Elodie, Djabari, Zied, Cai, Feng, Tran, Diem H., Vu, Hieu S., Ali, Eunus S., Rion, Halie, O’Hara, Brendan P., Kelekar, Sherwin, Hallett, James Hughes, Martin, Misty, Mathews, Thomas P., Gao, Peng, Asara, John M., Manning, Brendan D., Ben-Sahra, Issam, Hoxhaj, Gerta

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The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels von Hoxhaj, Gerta, Hughes-Hallett, James, Timson, Rebecca C., Ilagan, Erika, Yuan, Min, Asara, John M., Ben-Sahra, Issam, Manning, Brendan D.

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Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans von Heintz, Caroline, Doktor, Thomas K., Lanjuin, Anne, Escoubas, Caroline C., Zhang, Yue, Weir, Heather J., Dutta, Sneha, Silva-García, Carlos Giovanni, Bruun, Gitte H., Morantte, Ianessa, Hoxhaj, Gerta, Manning, Brendan D., Andresen, Brage S., Mair, William B.

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Effect of IRS4 levels on PI 3-kinase signalling von Hoxhaj, Gerta, Dissanayake, Kumara, MacKintosh, Carol

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GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing von Yu, Dong-Min, Zhao, Jiawei, Lee, Eunice E, Kim, Dohun, Mahapatra, Ruchika, Rose, Elysha K, Zhou, Zhiwei, Hosler, Calvin, El Kurdi, Abdullah, Choe, Jun-Yong, Abel, E Dale, Hoxhaj, Gerta, Westover, Kenneth D, Cho, Raymond J, Cheng, Jeffrey B, Wang, Richard C

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The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids von Hoxhaj, Gerta, Caddye, Edward, Najafov, Ayaz, Houde, Vanessa P, Johnson, Catherine, Dissanayake, Kumara, Toth, Rachel, Campbell, David G, Prescott, Alan R, MacKintosh, Carol

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth von Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.

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Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival von Kim, Dohun, Hoxhaj, Gerta

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Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin von Byles, Vanessa, Cormerais, Yann, Kalafut, Krystle, Barrera, Victor, Hughes Hallett, James E., Sui, Shannan Ho, Asara, John M., Adams, Christopher M., Hoxhaj, Gerta, Ben-Sahra, Issam, Manning, Brendan D.

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Itaconate-producing neutrophils regulate local and systemic inflammation following trauma von Crossley, Janna L, Ostashevskaya-Gohstand, Sonya, Comazzetto, Stefano, Hook, Jessica S, Guo, Lei, Vishlaghi, Neda, Juan, Conan, Xu, Lin, Horswill, Alexander R, Hoxhaj, Gerta, Moreland, Jessica G, Tower, Robert J, Levi, Benjamin

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MENA is a transcriptional target of the Wnt/beta-catenin pathway von Najafov, Ayaz, Seker, Tuncay, Even, Ipek, Hoxhaj, Gerta, Selvi, Osman, Ozel, Duygu Esen, Koman, Ahmet, Birgül-İyison, Necla

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Career pathways, part 11 von Hoxhaj, Gerta, Reznik, Ed

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An Erythropoietin Autocrine/Paracrine Axis Modulates the Growth and Survival of Human Prostate Cancer Cells von Jeong, Jee-Yeong, Hoxhaj, Gerta, Socha, Amanda L, Sytkowski, Arthur J, Feldman, Laurie

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Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets von Kavak, Ersen, Najafov, Ayaz, Ozturk, Nuri, Seker, Tuncay, Cavusoglu, Kader, Aslan, Tolga, Duru, Adil Doganay, Saygili, Tahsin, Hoxhaj, Gerta, Hiz, Mahmut Can, Unal, Durisehvar Ozer, Birgül-İyison, Necla, Ozturk, Mehmet, Koman, Ahmet

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Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase von Hoxhaj, Gerta, Najafov, Ayaz, Toth, Rachel, Campbell, David G, Prescott, Alan R, MacKintosh, Carol

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