Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer von Bradbury, Robert H., Acton, David G., Broadbent, Nicola L., Brooks, A. Nigel, Carr, Gregory R., Hatter, Glenn, Hayter, Barry R., Hill, Kathryn J., Howe, Nicholas J., Jones, Rhys D.O., Jude, David, Lamont, Scott G., Loddick, Sarah A., McFarland, Heather L., Parveen, Zaieda, Rabow, Alfred A., Sharma-Singh, Gorkhn, Stratton, Natalie C., Thomason, Andrew G., Trueman, Dawn, Walker, Graeme E., Wells, Stuart L., Wilson, Joanne, Wood, J. Matthew

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ChemInform Abstract: Synthesis of the Novel Tetrahydropyrazolo[3,4-c]pyridin-5-one Scaffold von Howe, Nicholas J., Blades, Kevin, Lamont, Gillian M.

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Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity von McCoull, William, Hennessy, Edward J., Blades, Kevin, Box, Matthew R., Chuaqui, Claudio, Dowling, James E., Davies, Christopher D., Ferguson, Andrew D., Goldberg, Frederick W., Howe, Nicholas J., Kemmitt, Paul D., Lamont, Gillian M., Madden, Katrina, McWhirter, Claire, Varnes, Jeffrey G., Ward, Richard A., Williams, Jason D., Yang, Bin

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Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivityElectronic supplementary information (ESI) available: Synthetic details f... von McCoull, William, Hennessy, Edward J, Blades, Kevin, Box, Matthew R, Chuaqui, Claudio, Dowling, James E, Davies, Christopher D, Ferguson, Andrew D, Goldberg, Frederick W, Howe, Nicholas J, Kemmitt, Paul D, Lamont, Gillian M, Madden, Katrina, McWhirter, Claire, Varnes, Jeffrey G, Ward, Richard A, Williams, Jason D, Yang, Bin

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The landscape of anthropogenic mortality: how African lions respond to spatial variation in risk von Loveridge, Andrew J., Valeix, Marion, Elliot, Nicholas B., Macdonald, David W.

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AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion von Cunniff, Brian, McKenzie, Andrew J, Heintz, Nicholas H, Howe, Alan K

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Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection von Howe, William M, Gritton, Howard J, Lusk, Nicholas A, Roberts, Erik A, Hetrick, Vaughn L, Berke, Joshua D, Sarter, Martin

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Shared processing in multiple object tracking and visual working memory in the absence of response order and task order confounds von Lapierre, Mark D, Cropper, Simon J, Howe, Piers D L

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Intraneural ganglion cysts: a systematic review and reinterpretation of the world's literature von Desy, Nicholas M, Wang, Huan, Elshiekh, Mohanad Ahmed Ibrahim, Tanaka, Shota, Choi, Tae Woong, Howe, B Matthew, Spinner, Robert J

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Viral proteins as a potential driver of histone depletion in dinoflagellates von Irwin, Nicholas A. T., Martin, Benjamin J. E., Young, Barry P., Browne, Martin J. G., Flaus, Andrew, Loewen, Christopher J. R., Keeling, Patrick J., Howe, LeAnn J.

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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed... von Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration von Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

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Assessing the Causal Role of Body Mass Index on Cardiovascular Health in Young Adults: Mendelian Randomization and Recall-by-Genotype Analyses von Wade, Kaitlin H, Chiesa, Scott T, Hughes, Alun D, Chaturvedi, Nish, Charakida, Marietta, Rapala, Alicja, Muthurangu, Vivek, Khan, Tauseef, Finer, Nicholas, Sattar, Naveed, Howe, Laura D, Fraser, Abigail, Lawlor, Debbie A, Davey Smith, George, Deanfield, John E, Timpson, Nicholas J

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Association of a body mass index genetic risk score with growth throughout childhood and adolescence von Warrington, Nicole M, Howe, Laura D, Wu, Yan Yan, Timpson, Nicholas J, Tilling, Kate, Pennell, Craig E, Newnham, John, Davey-Smith, George, Palmer, Lyle J, Beilin, Lawrence J, Lye, Stephen J, Lawlor, Debbie A, Briollais, Laurent

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The Function and Evolution of Motile DNA Replication Systems in Ciliates von Irwin, Nicholas A.T., Pittis, Alexandros A., Mathur, Varsha, Howe, LeAnn J., Keeling, Patrick J., Lynn, Denis H., Bourland, William A.

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Associations of Body Mass and Fat Indexes With Cardiometabolic Traits von Bell, Joshua A., Carslake, David, O’Keeffe, Linda M., Frysz, Monika, Howe, Laura D., Hamer, Mark, Wade, Kaitlin H., Timpson, Nicholas J., Davey Smith, George

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Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade von Wang, Ying, Nanda, Vivek, Direnzo, Daniel, Ye, Jianqin, Xiao, Sophia, Kojima, Yoko, Howe, Kathryn L., Jarr, Kai-Uwe, Flores, Alyssa M., Tsantilas, Pavlos, Tsao, Noah, Rao, Abhiram, Newmane, Alexandra A. C., Eberhard, Anne V., Priest, James R., Ruusalepp, Arno, Pasterkamp, Gerard, Maegdefessel, Lars, Miller, Clint L., Lind, Lars, Koplev, Simon, Björkegren, Johan L. M., Owense, Gary K., Ingelsson, Erik, Weissmanr, Irving L., Leeper, Nicholas J.

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Tiger sharks support the characterization of the world’s largest seagrass ecosystem von Gallagher, Austin J., Brownscombe, Jacob W., Alsudairy, Nourah A., Casagrande, Andrew B., Fu, Chuancheng, Harding, Lucy, Harris, S. David, Hammerschlag, Neil, Howe, Wells, Huertas, Antonio Delgado, Kattan, Sami, Kough, Andrew S., Musgrove, Andre, Payne, Nicholas L., Phillips, Adrian, Shea, Brendan D., Shipley, Oliver N., Sumaila, U. Rashid, Hossain, Mohammad S., Duarte, Carlos M.

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The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice von Bitsikas, Vassilis, Riento, Kirsi, Howe, Jonathan D, Barry, Nicholas P, Nichols, Benjamin J

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Accuracy of Dose Calibrators for 68Ga PET Imaging: Unexpected Findings in a Multicenter Clinical Pretrial Assessment von Bailey, Dale L, Hofman, Michael S, wood, Nicholas J, O'Keefe, Graeme J, Scott, Andrew M, van Wyngaardt, Winifred M, Howe, Bonnie, Kovacev, Olga, Francis, Roslyn J

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