Carcinogenesis of Pancreatic Ductal Adenocarcinoma von Storz, Peter, Crawford, Howard C.

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Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation von Crawford, Howard C.

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Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions von Liou, Geou-Yarh, Döppler, Heike, DelGiorno, Kathleen E., Zhang, Lizhi, Leitges, Michael, Crawford, Howard C., Murphy, Michael P., Storz, Peter

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Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption von Liu, Jun, Gao, Ming, Nipper, Michael, Deng, Janice, Sharkey, Francis E, Johnson, Randy L, Crawford, Howard C, Chen, Yidong, Wang, Pei

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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer von Halbrook, Christopher J., Pontious, Corbin, Kovalenko, Ilya, Lapienyte, Laura, Dreyer, Stephan, Lee, Ho-Joon, Thurston, Galloway, Zhang, Yaqing, Lazarus, Jenny, Sajjakulnukit, Peter, Hong, Hanna S., Kremer, Daniel M., Nelson, Barbara S., Kemp, Samantha, Zhang, Li, Chang, David, Biankin, Andrew, Shi, Jiaqi, Frankel, Timothy L., Crawford, Howard C., Morton, Jennifer P., Pasca di Magliano, Marina, Lyssiotis, Costas A.

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Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer von Saloman, Jami L., Albers, Kathryn M., Li, Dongjun, Hartman, Douglas J., Crawford, Howard C., Muha, Emily A., Rhim, Andrew D., Davis, Brian M.

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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids von Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B, Crawford, Howard C, Arrowsmith, Cheryl, Kalloger, Steve E, Renouf, Daniel J, Connor, Ashton A, Cleary, Sean, Schaeffer, David F, Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil K

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Loss of FOXA1/2 Is Essential for the Epithelial-to-Mesenchymal Transition in Pancreatic Cancer von YAN SONG, WASHINGTON, M. Kay, CRAWFORD, Howard C

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Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis von Crawford, Howard C., Pasca di Magliano, Marina, Banerjee, Sulagna

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Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs von Liou, Geou-Yarh, Döppler, Heike, Necela, Brian, Krishna, Murli, Crawford, Howard C, Raimondo, Massimo, Storz, Peter

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Epithelial-Stromal Interactions in Pancreatic Cancer von Zhang, Yaqing, Crawford, Howard C, Pasca di Magliano, Marina

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EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis von Ardito, Christine M., Grüner, Barbara M., Takeuchi, Kenneth K., Lubeseder-Martellato, Clara, Teichmann, Nicole, Mazur, Pawel K., DelGiorno, Kathleen E., Carpenter, Eileen S., Halbrook, Christopher J., Hall, Jason C., Pal, Debjani, Briel, Thomas, Herner, Alexander, Trajkovic-Arsic, Marija, Sipos, Bence, Liou, Geou-Yarh, Storz, Peter, Murray, Nicole R., Threadgill, David W., Sibilia, Maria, Washington, M. Kay, Wilson, Carole L., Schmid, Roland M., Raines, Elaine W., Crawford, Howard C., Siveke, Jens T.

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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling von Li, Xue, Maretzky, Thorsten, Weskamp, Gisela, Monette, Sébastien, Qing, Xiaoping, Issuree, Priya Darshinee A., Crawford, Howard C., McIlwain, David R., Mak, Tak W., Salmon, Jane E., Blobel, Carl P.

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Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice von Perusina Lanfranca, Mirna, Zhang, Yaqing, Girgis, Alexander, Kasselman, Samantha, Lazarus, Jenny, Kryczek, Illona, Delrosario, Lawrence, Rhim, Andrew, Koneva, Lada, Sartor, Maureen, Sun, Lei, Halbrook, Christopher, Nathan, Hari, Shi, Jiaqi, Crawford, Howard C., Pasca di Magliano, Marina, Zou, Weiping, Frankel, Timothy L.

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STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis von D'Amico, Stephen, Shi, Jiaqi, Martin, Benjamin L, Crawford, Howard C, Petrenko, Oleksi, Reich, Nancy C

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Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis von Zhang, Yaqing, Lazarus, Jenny, Steele, Nina G., Yan, Wei, Lee, Ho-Joon, Nwosu, Zeribe C., Halbrook, Christopher J., Menjivar, Rosa E., Kemp, Samantha B., Sirihorachai, Veerin R., Velez-Delgado, Ashley, Donahue, Katelyn, Carpenter, Eileen S., Brown, Kristee L., Irizarry-Negron, Valerie, Nevison, Anna C., Vinta, Alekya, Anderson, Michelle A., Crawford, Howard C., Lyssiotis, Costas A., Frankel, Timothy L., Bednar, Filip, di Magliano, Marina Pasca

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Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-kappa B-Mediated Production of CXCL1 von Kemp, Samantha B., Carpenter, Eileen S., Steele, Nina G., Donahue, Katelyn L., Nwosu, Zeribe C., Pacheco, Amanda, Velez-Delgado, Ashley, Menjivar, Rosa E., Lima, Fatima, The, Stephanie, Espinoza, Carlos E., Brown, Kristee, Long, Daniel, Lyssiotis, Costas A., Rao, Arvind, Zhang, Yaqing, di Magliano, Marina Pasca, Crawford, Howard C.

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Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer von Steele, Nina G., Biffi, Giulia, Kemp, Samantha B., Zhang, Yaqing, Drouillard, Donovan, Syu, LiJyun, Hao, Yuan, Oni, Tobiloba E., Brosnan, Erin, Elyada, Ela, Doshi, Abhishek, Hansma, Christa, Espinoza, Carlos, Abbas, Ahmed, The, Stephanie, Irizarry-Negron, Valerie, Halbrook, Christopher J., Franks, Nicole E., Hoffman, Megan T., Brown, Kristee, Carpenter, Eileen S., Nwosu, Zeribe C., Johnson, Craig, Lima, Fatima, Anderson, Michelle A., Park, Youngkyu, Crawford, Howard C., Lyssiotis, Costas A., Frankel, Timothy L., Rao, Arvind, Bednar, Filip, Dlugosz, Andrzej A., Preall, Jonathan B., Tuveson, David A., Allen, Benjamin L., di Magliano, Marina Pasca

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NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer von Chio, Iok In Christine, Jafarnejad, Seyed Mehdi, Ponz-Sarvise, Mariano, Park, Youngkyu, Rivera, Keith, Palm, Wilhelm, Wilson, John, Sangar, Vineet, Hao, Yuan, Öhlund, Daniel, Wright, Kevin, Filippini, Dea, Lee, Eun Jung, Da Silva, Brandon, Schoepfer, Christina, Wilkinson, John Erby, Buscaglia, Jonathan M., DeNicola, Gina M., Tiriac, Herve, Hammell, Molly, Crawford, Howard C., Schmidt, Edward E., Thompson, Craig B., Pappin, Darryl J., Sonenberg, Nahum, Tuveson, David A.

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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism von Bott, Alex J., Shen, Jianliang, Tonelli, Claudia, Zhan, Le, Sivaram, Nithya, Jiang, Ya-Ping, Yu, Xufen, Bhatt, Vrushank, Chiles, Eric, Zhong, Hua, Maimouni, Sara, Dai, Weiwei, Velasquez, Stephani, Pan, Ji-An, Muthalagu, Nathiya, Morton, Jennifer, Anthony, Tracy G., Feng, Hui, Lamers, Wouter H., Murphy, Daniel J., Guo, Jessie Yanxiang, Jin, Jian, Crawford, Howard C., Zhang, Lanjing, White, Eileen, Lin, Richard Z., Su, Xiaoyang, Tuveson, David A., Zong, Wei-Xing

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