ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies von Zammarchi, Francesca, Corbett, Simon, Adams, Lauren, Tyrer, Peter C., Kiakos, Konstantinos, Janghra, Narinder, Marafioti, Teresa, Britten, Charles E., Havenith, Carin E.G., Chivers, Simon, D'Hooge, Francois, Williams, David G., Tiberghien, Arnaud, Howard, Philip W., Hartley, John A., van Berkel, Patrick H.

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SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads von Kinneer, Krista, Meekin, John, Tiberghien, Arnaud C, Tai, Yu-Tzu, Phipps, Sandrina, Kiefer, Christine Mione, Rebelatto, Marlon C, Dimasi, Nazzareno, Moriarty, Alyssa, Papadopoulos, Kyriakos P, Sridhar, Sriram, Gregson, Stephen J, Wick, Michael J, Masterson, Luke, Anderson, Kenneth C, Herbst, Ronald, Howard, Philip W, Tice, David A

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Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine von Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.

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Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry von VanBrunt, Michael P, Shanebeck, Kurt, Caldwell, Zachary, Johnson, Jeffrey, Thompson, Pamela, Martin, Thomas, Dong, Huifang, Li, Gary, Xu, Hengyu, D’Hooge, Francois, Masterson, Luke, Bariola, Pauline, Tiberghien, Arnaud, Ezeadi, Ebele, Williams, David G, Hartley, John A, Howard, Philip W, Grabstein, Kenneth H, Bowen, Michael A, Marelli, Marcello

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Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload von Tiberghien, Arnaud C, Levy, Jean-Noel, Masterson, Luke A, Patel, Neki V, Adams, Lauren R, Corbett, Simon, Williams, David G, Hartley, John A, Howard, Philip W

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ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies von Flynn, Michael J, Zammarchi, Francesca, Tyrer, Peter C, Akarca, Ayse U, Janghra, Narinder, Britten, Charles E, Havenith, Carin E G, Levy, Jean-Noel, Tiberghien, Arnaud, Masterson, Luke A, Barry, Conor, D'Hooge, Francois, Marafioti, Teresa, Parren, Paul W H I, Williams, David G, Howard, Philip W, van Berkel, Patrick H, Hartley, John A

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TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors von Gymnopoulos, Marco, Betancourt, Oscar, Blot, Vincent, Fujita, Ryo, Galvan, Diana, Lieuw, Vincent, Nguyen, Sophie, Snedden, Jeanette, Stewart, Christine, Villicana, Jose, Wojciak, Jon, Wong, Eley, Pardo, Raul, Patel, Neki, D’Hooge, Francois, Vijayakrishnan, Balakumar, Barry, Conor, Hartley, John A., Howard, Philip W., Newman, Roland, Coronella, Julia

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Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78 von Kotecha, Minal, Kluza, Jerome, Wells, Geoff, O'Hare, C Caroline, Forni, Claudia, Mantovani, Roberto, Howard, Philip W, Morris, Peter, Thurston, David E, Hartley, John A, Hochhauser, Daniel

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Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation von Christie, R., Tiberghien, Arnaud, Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip, Gao, Changshou

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Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents von Antonow, Dyeison, Kaliszczak, Maciej, Kang, Gyoung-Dong, Coffils, Marissa, Tiberghien, Arnaud C, Cooper, Nectaroula, Barata, Teresa, Heidelberger, Sibylle, James, Colin H, Zloh, Mire, Jenkins, Terence C, Reszka, Anthony P, Neidle, Stephen, Guichard, Sylvie M, Jodrell, Duncan I, Hartley, John A, Howard, Philip W, Thurston, David E

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A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology von Jeffrey, Scott C, Burke, Patrick J, Lyon, Robert P, Meyer, David W, Sussman, Django, Anderson, Martha, Hunter, Joshua H, Leiske, Chris I, Miyamoto, Jamie B, Nicholas, Nicole D, Okeley, Nicole M, Sanderson, Russell J, Stone, Ivan J, Zeng, Weiping, Gregson, Stephen J, Masterson, Luke, Tiberghien, Arnaud C, Howard, Philip W, Thurston, David E, Law, Che-Leung, Senter, Peter D

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The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer-Containing Antibody-Drug Conjugates von Corbett, Simon, Huang, Shiran, Zammarchi, Francesca, Howard, Philip W., van Berkel, Patrick H., Hartley, John A.

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Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 von Kinneer, Krista, Wortmann, Philipp, Cooper, Zachary A, Dickinson, Niall J, Masterson, Luke, Cailleau, Thais, Hutchinson, Ian, Vijayakrishnan, Balakumar, McFarlane, Mary, Ball, Kathryn, Davies, Michael, Lewis, Arthur, Huang, Yue, Rosenbaum, Anton I, Yuan, Jiaqi, Chesebrough, Jon, Anderton, Judith, Monks, Noel, Novick, Steven, Wang, Jixin, Dimasi, Nazzareno, Christie, R James, Sabol, Darrin, Tosto, Frances Anne, Wallez, Yann, Leo, Elisabetta, Albertella, Mark R, Staniszewska, Anna D, Tice, David A, Howard, Philip W, Luheshi, Nadia, Sapra, Puja

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Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells von Kinneer, Krista, Flynn, Matt, Thomas, Suneetha B., Meekin, John, Varkey, Reena, Xiao, Xiaodong, Zhong, Haihong, Breen, Shannon, Hynes, Paul G., Fleming, Ryan, Bezabeh, Binyam, Chen, Cui (Tracy), Wetzel, Leslie, Chen, Ruoyan, Dimasi, Nazzareno, Tai, Yu-Tzu, Anderson, Kenneth C., Herbst, Ronald, Howard, Philip W., Hurt, Elaine M., Tice, David A.

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Solution Structure of a 2:1 C2-(2-Naphthyl) Pyrrolo[2,1-c][1,4]benzodiazepine DNA Adduct: Molecular Basis for Unexpectedly High DNA Helix Stabilization von Antonow, Dyeison, Barata, Teresa, Jenkins, Terence C, Parkinson, Gary N, Howard, Philip W, Thurston, David E, Zloh, Mire

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Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates von Wells, Geoff, Martin, Christopher R. H, Howard, Philip W, Sands, Zara A, Laughton, Charles A, Tiberghien, Arnaud, Woo, Chi Kit, Masterson, Luke A, Stephenson, Marissa J, Hartley, John A, Jenkins, Terence C, Shnyder, Steven D, Loadman, Paul M, Waring, Michael J, Thurston, David E

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Simultaneous monitoring of multiple attributes of pyrrolobenzodiazepine antibody-drug conjugates by size exclusion chromatography – high resolution mass spectrometry von Füssl, Florian, Barry, Conor S., Pugh, Kathryn M., Chooi, K. Phin, Vijayakrishnan, Balakumar, Kang, Gyoung-Dong, von Bulow, Christina, Howard, Philip W., Bones, Jonathan

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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity von Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W

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Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR von Mao, Shenlan, Chaerkady, Raghothama, Yu, Wen, D'Angelo, Gina, Garcia, Andrew, Chen, Hong, Barrett, Allison M., Phipps, Sandrina, Fleming, Ryan, Hess, Sonja, Koopmann, Jens-Oliver, Dimasi, Nazzareno, Wilson, Susan, Pugh, Kathryn, Cook, Kimberly, Masterson, Luke A., Gao, Changshou, Wu, Herren, Herbst, Ronald, Howard, Philip W., Tice, David A., Cobbold, Mark, Harper, Jay

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Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer von Gregson, Stephen J., Pugh, Kathryn, Patel, Neki, Afif-Rider, Shameen, Vijayakrishnan, Balakumar, Santos, Kathleen, Riedl, Jitka, Hutchinson, Ian, Kang, Gyoung-Dong, Chooi, K. Phin, Beard, Rhiannon, Adams, Lauren, Barry, Conor S., Ball, Kathryn, Masterson, Luke A., McFarlane, Mary, Hartley, John A., Howard, Philip W.

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