CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory von Benonisson, Hreinn, Altıntaş, Işıl, Sluijter, Marjolein, Verploegen, Sandra, Labrijn, Aran F, Schuurhuis, Danita H, Houtkamp, Mischa A, Verbeek, J Sjef, Schuurman, Janine, van Hall, Thorbald

Volltext

Systematic study of tissue factor expression in solid tumors von Bono, Johann S., Harris, Jeffrey R., Burm, Saskia M., Vanderstichele, Adriaan, Houtkamp, Mischa A., Aarass, Saida, Riisnaes, Ruth, Figueiredo, Ines, Nava Rodrigues, Daniel, Christova, Rossitza, Olbrecht, Siel, Niessen, Hans W. M., Ruuls, Sigrid R., Schuurhuis, Danita H., Lammerts van Bueren, Jeroen J., Breij, Esther C. W., Vergote, Ignace

Volltext

Neutralization of IL-8 prevents the induction of dermatologic adverse events associated with the inhibition of epidermal growth factor receptor von Bangsgaard, Nannie, Houtkamp, Mischa, Schuurhuis, Danita H, Parren, Paul W H I, Baadsgaard, Ole, Niessen, Hans W M, Skov, Lone

Volltext

Effect of target dynamics on pharmacokinetics of a novel therapeutic antibody against the epidermal growth factor receptor : Implications for the mechanisms of action von LAMMERTS VAN BUEREN, Jeroen J, BLEEKER, Wim K, BOGH, Henrik O, HOUTKAMP, Mischa, SCHUURMAN, Janine, VAN DE WINKEL, Jan G. J, PARREN, Paul W. H. I

Volltext

863 In vitro and in vivo studies establish DuoBody®-CD3xB7H4 as a novel drug candidate for the treatment of solid cancers von Koopman, Louise, Vries, Laura Smits-de, Egerod, Frederikke Lihme, Wubben, Sebastiaan, Houtkamp, Mischa, Poot, Stefanie De, Paauwe, Madelon, Brink, Edward van den, Gorlani, Andrea, Verzijl, Dennis, Sasser, Kate, Breij, Esther

Volltext

Dual Mode of Action of a Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Cancer Therapy von Bleeker, Wim K, Lammerts van Bueren, Jeroen J, van Ojik, Heidi H, Gerritsen, Arnout F, Pluyter, Marielle, Houtkamp, Mischa, Halk, Ed, Goldstein, Joel, Schuurman, Janine, van Dijk, Marc A, van de Winkel, Jan G. J, Parren, Paul W. H. I

Volltext

704 Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody®-CD3x5T4 in vitro and in vivo in solid cancer models von Kemper, Kristel, Gielen, Ellis, Houtkamp, Mischa, Boross, Peter, Burm, Saskia, Poot, Stefanie De, Engelberts, Patrick, Goeij, Bart de, Satijn, David, Sasser, Kate, Breij, Esther

Volltext

Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses von Houtkamp, Mischa A., de Boer, Onno J., van der Loos, Chris M., van der Wal, Allard C., Becker, Anton E.

Volltext

Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade von Boshuizen, Julia, Pencheva, Nora, Krijgsman, Oscar, Altimari, Daniela D'Empaire, Castro, Patricia Garrido, de Bruijn, Beaunelle, Ligtenberg, Maarten A, Gresnigt-Van den Heuvel, Elke, Vredevoogd, David W, Song, Ji-Ying, Visser, Nils, Apriamashvili, Georgi, Janmaat, Maarten L, Plantinga, Theo S, Franken, Patrick, Houtkamp, Mischa, Lingnau, Andreas, Jure-Kunkel, Maria, Peeper, Daniel S

Volltext

An Antibody-Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors von BREIJ, Esther C. W, DE GOEIJ, Bart E. C. G, PARREN, Paul W. H. I, VERPLOEGEN, Sandra, SCHUURHUIS, Danita H, AMIRKHOSRAVI, Ali, FRANCIS, John, MILLER, Vibeke Breinholt, HOUTKAMP, Mischa, BLEEKER, Wim K, SATIJN, David

Volltext

Spatial genomics to reveal an immunosuppressive tumor microenvironment after chemoradiation in head and neck cancer patients von Choe, Jennifer Hsing, Jabado, Omar, Jiang, Xiaoyin Sara, Fan, Li, Franken, Patrick, Houtkamp, Mischa, Ma-Edmonds, Manling, Loya, Matthew, Adams, Homer, Jure-Kunkel, Maria, Fereshteh, Mark, Pencheva, Nora, Nixon, Andrew B.

Volltext

An Antibody-Drug Conjugate Directed to Tissue Factor Shows Preclinical Antitumor Activity in Head and Neck Cancer as a Single Agent and in Combination with Chemoradiotherapy von Bakema, Jantine E, Stigter-van Walsum, Marijke, Harris, Jeffrey R, Ganzevles, Sonja H, Muthuswamy, Anantharaman, Houtkamp, Mischa, Plantinga, Theo S, Bloemena, Elisabeth, Brakenhoff, Ruud H, Breij, Esther C W, van de Ven, Rieneke

Volltext

Interleukin-15 Expression in Atherosclerotic Plaques: An Alternative Pathway for T-Cell Activation in Atherosclerosis? von Houtkamp, Mischa A, van der Wal, Allard C, de Boer, Onno J, van der Loos, Chris M, de Boer, Piet A.J, Moorman, Antoon F.M, Becker, Anton E

Volltext

Abstract IA004: Preclinical development of DuoBody®-CD3xB7H4, a novel CD3 bispecific antibody for the treatment of solid cancers von Koopman, Louise A, Alemdehy, Farshid, Paauwe, Madelon, Vries, Laura Smits-de, Karaiskaki, Frosso, Brandhorst, Marcel, Franken, Patrick, Plantinga, Theo S, Houtkamp, Mischa A, de Poot, Stefanie A.H., Breij, Esther C.W.

Volltext

Abstract 634: Novel antibody-drug conjugates targeting Axl show anti-tumor activity in solid cancer xenograft models von Breij, Esther C.W., Verploegen, Sandra, Lingnau, Andreas, van den Brink, Edward N., Janmaat, Maarten, Houtkamp, Mischa, Bleeker, Wim K., Satijn, David, Parren, Paul W.H.I.

Volltext

Preclinical efficacy studies using HuMax-Axl-ADC, a novel antibody-drug conjugate targeting Axl-expressing solid cancers von Breij, Esther CW, Verploegen, Sandra, Lingnau, Andreas, van den Brink, Edward N, Janmaat, Maarten, Houtkamp, Mischa, Bleeker, Wim, Satijn, David, Parren, Paul

Volltext

Systematic study of tissue factor expression in solid tumors von de Bono, Johann S, Harris, Jeffrey R, Burm, Saskia M, Vanderstichele, Adriaan, Houtkamp, Mischa A, Aarass, Saida, Riisnaes, Ruth, Figueiredo, Ines, Rodrigues, Daniel Nava, Christova, Rossitza, Olbrecht, Siel, Niessen, Hans W.M, Ruuls, Sigrid R, Schuurhuis, Danita H, van Bueren, Jeroen J. Lammerts, Breij, Esther C.W, Vergote, Ignace

Volltext

Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models von Kemper, Kristel, Gielen, Ellis, Boross, Peter, Houtkamp, Mischa, Plantinga, Theo S, de Poot, Stefanie Ah, Burm, Saskia M, Janmaat, Maarten L, Koopman, Louise A, van den Brink, Edward N, Rademaker, Rik, Verzijl, Dennis, Engelberts, Patrick J, Satijn, David, Sasser, A Kate, Breij, Esther Cw

Volltext

Use of an antibody-drug conjugate targeting tissue factor to induce complete tumor regression in xenograft models with heterogeneous target expression von Breij, Esther CW, Satijn, David, Verploegen, Sandra, de Goeij, Bart, Schuurhuis, Danita, Bleeker, Wim, Houtkamp, Mischa, Parren, Paul

Volltext

Abstract 1234: An antibody-drug conjugate targeting tissue factor with broad anti-tumor efficacy in xenograft models with heterogeneous tissue factor expression von Breij, Esther C.W., Satijn, David, Verploegen, Sandra, de Goeij, Bart E., Schuurhuis, Danita H., Houtkamp, Mischa, Bleeker, Wim K., Parren, Paul W.

Volltext