Allopurinol Reduces Left Ventricular Mass in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy von Szwejkowski, Benjamin R., MBChB, Gandy, Stephen J., PhD, Rekhraj, Sushma, MBChB, Houston, John G., MD, Lang, Chim C., MD, Morris, Andrew D., MD, George, Jacob, MD, Struthers, Allan D., MD

Volltext

Discovery of (5S,6S,9R)‑5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro‑5H‑cyclohepta[b]pyridin-9-yl 4‑(2-oxo-2,3-dihydro‑1H‑imidazo[4,5‑b]pyridin-1-yl)piperidine-1-carboxylate (... von Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.

Volltext

Case study: technology initiative led to advanced lead optimization screening processes at Bristol-Myers Squibb, 2004–2009 von Zhang, Litao, Cvijic, Mary Ellen, Lippy, Jonathan, Myslik, James, Brenner, Stephen L., Binnie, Alastair, Houston, John G.

Volltext

Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves von Singh, Anvesha, Horsfield, Mark A., Bekele, Soliana, Greenwood, John P., Dawson, Dana K., Berry, Colin, Hogrefe, Kai, Kelly, Damian J., Houston, John G., Guntur Ramkumar, Prasad, Uddin, Akhlaque, Suzuki, Toru, McCann, Gerry P.

Volltext

Metformin Regresses Left Ventricular Hypertrophy in Normotensive Patients with Coronary Artery Disease without Type 2 Diabetes Mellitus—The MET-REMODEL Trial von MOHAN, MOHAPRADEEP, AL-TALABANY, SHAWEEN, MCKINNIE, ANGELA M., MORDI, IFY, SINGH, JAGDEEP S., GANDY, STEPHEN J., CHOY, ANNAMARIA, HOUSTON, JOHN G., GEORGE, JACOB, STRUTHERS, ALLAN D., LANG, CHIM C.

Volltext

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor von Gillman, Kevin W, Starrett, John E, Parker, Michael F, Xie, Kai, Bronson, Joanne J, Marcin, Lawrence R, McElhone, Kate E, Bergstrom, Carl P, Mate, Robert A, Williams, Richard, Meredith, Jere E, Burton, Catherine R, Barten, Donna M, Toyn, Jeremy H, Roberts, Susan B, Lentz, Kimberley A, Houston, John G, Zaczek, Robert, Albright, Charles F, Decicco, Carl P, Macor, John E, Olson, Richard E

Volltext

Renal Artery Stenosis—When To Screen, What To Stent? von Jennings, Claudine G., Houston, John G., Severn, Alison, Bell, Samira, Mackenzie, Isla S., MacDonald, Thomas M.

Volltext

Non-contrast MRI methods as a tool for the pre-operative assessment and surveillance of the arterio-venous fistula for haemodialysis von MacDonald, Conor J., Gandy, Stephen, Avison, Eilidh C. M., Matthew, Shona, Ross, Rose, Houston, John G.

Volltext

Case study: impact of technology investment on lead discovery at Bristol–Myers Squibb, 1998–2006 von Houston, John G., Banks, Martyn N., Binnie, Alastair, Brenner, Stephen, O’Connell, Jonathan, Petrillo, Edward W.

Volltext

Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity von Barten, Donna M, Meredith, Jr, Jere E, Zaczek, Robert, Houston, John G, Albright, Charles F

Volltext

Best Practices in Compound Management for Preserving Compound Integrity and Accurately Providing Samples for Assays von Matson, Sandra L., Chatterjee, Moneesh, Stock, David A., Leet, John E., Dumas, Elizabeth A., Ferrante, Christian D., Monahan, William E., Cook, Lynda S., Watson, John, Cloutier, Normand J., Ferrante, Meredith A., Houston, John G., Banks, Martyn N.

Volltext

The chemical-biological interface: developments in automated and miniaturised screening technology von Houston, John G, Banks, Martyn

Volltext

Gamma-secretase inhibitors have intrinsically different potencies against Aβ production and Notch signaling von Burton, Catherine R, Meredith, Jere E, Toyn, Jeremy H, Bradley, Jodi D, Wang, Qian, Sharp, Diane, Sisk, Lisa, Guss, Valerie, Polson, Craig, Krause, Carol M, Wardwell-Swanson, Judith, Guo, Qi, Fitzgerald, Kevin, Seiffert, Dietmar E, Stern, Andrew M, Olson, Richard E, Macor, John E, Zaczek, Robert, Houston, John G, Albright, Charles F

Volltext

Research into the Effect of Sodium-Glucose Linked Transporter 2 Inhibition on Left Ventricular Remodeling in Patients with Heart Failure and Diabetes Mellitus von SINGH, JAGDEEP S.S., MORDI, IFY, MOHAN, MOHAPRADEEP, GANDY, STEPHEN J., PEARSON, EWAN, HOUSTON, JOHN G., STRUTHERS, ALLAN D., LANG, CHIM C.

Volltext

The Effect of Metformin and Dapagliflozin on Epicardial Adipose Tissue in Prediabetes and Type 2 Diabetic Patients von AL-TALABANY, SHAWEEN, WEIR-MCCALL, JONATHAN, MOHAN, MOHAPRADEEP, SINGH, JAGDEEP S., MORDI, IFY, GANDY, STEPHEN J., KHAN, FAISEL, CHOY, ANNAMARIA, HOUSTON, JOHN G., PEARSON, EWAN, GEORGE, JACOB, STRUTHERS, ALLAN D., LANG, CHIM C.

Volltext

HTS: Productivity or Oblivion? von Houston, John G.

Volltext

Case study: technology initiative led to advanced lead optimization screening procsses at Bristol-Myers Squibb, 2004-2009 von LITAO ZHANG, ELLEN CVIJIC, Mary, LIPPY, Jonathan, MYSLIK, James, BRENNER, Stephen L, BINNIE, Alastair, HOUSTON, John G

Volltext

A 384-HTS for Human Factor VIIa: Comparison With 96- and 864-Well Formats von Comley, John C.W., Binnie, Alastair, Bonk, Caroline, Houston, John G.

Volltext

Discovery of (5 S ,6 S ,9 R )-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5 H -cyclohepta[ b ]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin-1-yl)piperidine-1... von Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.

Volltext

The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs von Procopiou, Panayiotis A, Bailey, Esme J, Bamford, Mark J, Craven, Andy P, Dymock, Brian W, Houston, John G, Hutson, Julie L, Kirk, Barrie E, McCarthy, Alun D

Volltext