153P Determinants of tumour-immune evolutionary trajectory in colorectal cancer von Lakatos, E., Gunasri, V., Zapata, L., Househam, J., Heide, T., Trahearn, N., Swinyard, O., Lynn, C., Cresswell, G., Mossner, M., Kimberley, C., Spiteri, I., Jansen, M., Rodriguez-Justo, M., Bridgewater, J.A., Baker, A-M., Sottoriva, A., Graham, T.

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416P Evolutionary and immune microenvironment dynamics determine response to neoadjuvant treatment of oesophageal adenocarcinoma von Barroux, M., Househam, J., Lakatos, E., Ronel, T., Baker, A-M., Salié, H., Mossner, M., Jansen, M., Caravagna, G., Steiger, K., Slotta-Huspenina, J., Weichert, W., Alberstmeier, M., Chain, B., Friess, H., Bengsch, B., Schmid, R., Siveke, J.T., Quante, M., Graham, T.

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The co-evolution of the genome and epigenome in colorectal cancer von Heide, T, Househam, J, Cresswell, GD, Spiteri, I, Lynn, C, Mossner, M, Kimberley, C, Fernandez-Mateos, J, Chen, B, Zapata, L, James, C, Barozzi, I, Chkhaidze, K, Nichol, D, Gunasri, V, Berner, A, Schmidt, M, Lakatos, E, Baker, A-M, Costa, H, Mitchinson, M, Piazza, R, Jansen, M, Caravagna, G, Ramazzotti, D, Shibata, D, Bridgewater, J, Rodriguez-Justo, M, Magnani, L, Graham, TA, Sottoriva, A

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Determinants of tumour-immune evolutionary trajectory in colorectal cancer von Lakatos, Eszter, Gunasri, V., Zapata, L., Househam, J., Heide, T., Trahearn, N., Swinyard, O., Lynn, C., Cresswell, G., Mossner, M., Kimberley, C., Spiteri, I., Jansen, M., Rodriguez-Justo, M., Bridgewater, J. A., Baker, A-M., Sottoriva, A., Graham, T.

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Evolutionary and immune microenvironment dynamics determine response to neoadjuvant treatment of oesophageal adenocarcinoma von Barroux, M., Househam, J., Lakatos, Eszter, Ronel, T., Baker, A-M., Salie, H., Mossner, M., Jansen, M., Caravagna, G., Steiger, K., Slotta-Huspenina, J., Weichert, W., Alberstmeier, M., Chain, B., Friess, H., Bengsch, B., Schmid, R., Siveke, J. T., Quante, M., Graham, T.

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The genomic landscape of 2,023 colorectal cancers von Cornish, A.J, Gruber, A.J, Kinnersley, B, Chubb, D, Frangou, A, Caravagna, G, Noyvert, B, Lakatos, E, Wood, H.M, Thorn, S, Culliford, R, Arnedo-Pac, C, Househam, J, Cross, W, Sud, A, Law, P, Leathlobhair, M.N, Hawari, A, Woolley, C, Sherwood, K, Feeley, N, Gül, G, Fernandez-Tajes, J, Zapata, L, Alexandrov, L.B, Murugaesu, N, Sosinsky, A, Mitchell, J, Lopez-Bigas, N, Quirke, P, Church, D.N, Tomlinson, I.P.M, Sottoriva, A, Graham, T.A, Wedge, D.C, Houlston, R.S

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Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues von Gabbutt, C, Schenck, RO, Weisenberger, DJ, Kimberley, C, Berner, A, Househam, J, Lakatos, E, Robertson-Tessi, M, Martin, I, Patel, R, Clark, SK, Latchford, A, Barnes, CP, Leedham, SJ, Anderson, ARA, Graham, TA, Shibata, D

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Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A von Hart, DP, Uzun, N, Skelton, S, Kakoschke, A, Househam, J, Moss, DS, Shepherd, AJ

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Evolutionary dynamics of neoantigens in growing tumors von Lakatos, E, Williams, MJ, Schenck, RO, Cross, WCH, Househam, J, Zapata, L, Werner, B, Gatenbee, C, Robertson-Tessi, M, Barnes, CP, Anderson, ARA, Sottoriva, A, Graham, TA

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Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues von Gabbutt, Calum, Schenck, Ryan O., Weisenberger, Daniel J., Kimberley, Christopher, Berner, Alison, Househam, Jacob, Lakatos, Eszter, Robertson-Tessi, Mark, Martin, Isabel, Patel, Roshani, Clark, Susan K., Latchford, Andrew, Barnes, Chris P., Leedham, Simon J., Anderson, Alexander R. A., Graham, Trevor A., Shibata, Darryl

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Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc von Antonello, Alice, Bergamin, Riccardo, Calonaci, Nicola, Househam, Jacob, Milite, Salvatore, Williams, Marc J, Anselmi, Fabio, d'Onofrio, Alberto, Sundaram, Vasavi, Sosinsky, Alona, Cross, William C H, Caravagna, Giulio

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Phenotypic noise and plasticity in cancer evolution von Whiting, Frederick J.H., Househam, Jacob, Baker, Ann-Marie, Sottoriva, Andrea, Graham, Trevor A.

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Evolutionary dynamics of neoantigens in growing tumors von Lakatos, Eszter, Williams, Marc J., Schenck, Ryan O., Cross, William C. H., Househam, Jacob, Zapata, Luis, Werner, Benjamin, Gatenbee, Chandler, Robertson-Tessi, Mark, Barnes, Chris P., Anderson, Alexander R. A., Sottoriva, Andrea, Graham, Trevor A.

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Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A von Hart, Daniel P, Uzun, Nazmiye, Skelton, Stuart, Kakoschke, Alison, Househam, Jacob, Moss, David S, Shepherd, Adrian J

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Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study von Dalton, Harry R., van Eijk, Jeroen J.J., Cintas, Pascal, Madden, Richie G., Jones, Catherine, Webb, Glynn W., Norton, Benjamin, Pique, Julie, Lutgens, Suzanne, Devooght-Johnson, Nikki, Woolson, Kathy, Baker, John, Saunders, Maria, Househam, Liz, Griffiths, James, Abravanel, Florence, Izopet, Jacques, Kamar, Nassim, van Alfen, Nens, van Engelen, Baziel G.M., Hunter, Jeremy G., van der Eijk, Annemiek A., Bendall, Richard P., Mclean, Brendan N., Jacobs, Bart C.

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The genomic landscape of 2,023 colorectal cancers von Cornish, Alex J., Gruber, Andreas J., Kinnersley, Ben, Chubb, Daniel, Frangou, Anna, Caravagna, Giulio, Noyvert, Boris, Lakatos, Eszter, Wood, Henry M., Thorn, Steve, Culliford, Richard, Arnedo-Pac, Claudia, Househam, Jacob, Cross, William, Sud, Amit, Law, Philip, Leathlobhair, Maire Ni, Hawari, Aliah, Woolley, Connor, Sherwood, Kitty, Feeley, Nathalie, Gül, Güler, Fernandez-Tajes, Juan, Zapata, Luis, Alexandrov, Ludmil B., Murugaesu, Nirupa, Sosinsky, Alona, Mitchell, Jonathan, Lopez-Bigas, Nuria, Quirke, Philip, Church, David N., Tomlinson, Ian P. M., Sottoriva, Andrea, Graham, Trevor A., Wedge, David C., Houlston, Richard S.

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Hepatitis E virus infection and acute non-traumatic neurological injury: an international prospective pilot study von Webb, G.W, van Eijk, J.J.J, Cintas, P, Norton, B, Madden, R.G, Jones, C, Hunter, J.G, Devooght-Johnson, N, Pique, J, Woolson, K, Saunders, M, Mclean, B.N, Househam, E, Griffiths, J, Bendall, R.P, Izopet, J, Kamar, N, Jacobs, B.C, Dalton, H.R

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Renal Transplantation in Pure Autonomic Failure von Ul Abideen, Zain, Rixon, Anna, Gunatillake, Nirosha D., Househam, Elizabeth, Mathias, Christopher J., Connor, Andrew

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Complications following sural and peroneal nerve biopsies von Hilton, David A, Jacob, John, Househam, Liz, Tengah, Connie

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Factors associated with the severity of COVID‐19 outcomes in people with neuromuscular diseases: Data from the International Neuromuscular COVID‐19 Registry von Pizzamiglio, Chiara, Pitceathly, Robert D. S., Lunn, Michael P., Brady, Stefen, De Marchi, Fabiola, Galan, Lucia, Heckmann, Jeannine M., Horga, Alejandro, Molnar, Maria J., Oliveira, Acary S. B., Pinto, Wladimir B. V. R., Primiano, Guido, Santos, Ernestina, Schoser, Benedikt, Servidei, Serenella, Sgobbi Souza, Paulo V., Venugopalan, Vishnu, Hanna, Michael G., Dimachkie, Mazen M., Machado, Pedro M., Lim, Albert, Elsaddig, Amar, Juanatey, Ana, Romeiro, Ana, Themistocleous, Andreas, Kiss‐Csenki, Annamaria, Guerrero Sola, Antonio, Patil, Anuja, Duggal, Ashish, Gabriel, Carolyn, Marshall, Charles, Record, Christopher, Allen, Claire, Bearden, David, Rathna Sabapathi, DeviPriya, R, Dileep, Vecchio, Domizia, Newman, Edward, Eshun, Edwin, Foo, Eng C., Bugiardini, Enrico, Burke, Georgina, Ramdharry, Gita, Gorman, Gràinne S., Kumar, Guru, Sivasathiaseelan, Harri, Braga Farias, Igor, Smuts, Izelle, Holt, James, Groothuis, Jan T., Pritchard, Jane, Wall, Jasmine, Gamez, Josep, Shakthi, K. J. S., Wannop, Kate, Brennan, Kathryn, Saavedra, Lillian, Clayton, Lisa, Househam, Liz, Skorupinska, Mariola, Laura, Matilde, Ciocca, Matteo, Zosmer, Maya, Dhamne, Megha, Mancuso, Michelangelo, Janssen, Mirian, Musumeci, Olimpia, Price, Olivia, Chinnery, Patrick F., Ambrose, Philip, Mehta, Puja R., Thomas, Rhys H., Horvath, Rita, McFarland, Robert, Nortley, Ross, Paterson, Ross W., Geraldes, Ruth, Keh, Ryan, Neshuku, Saara, Sasidharan, Sandhya, Menon R, Sarath, Raga, Sharika, Rinaldi, Simon, Yareeda, Sireesha, Desai, Soaham, Ramaratnam, Sridharan, Keddie, Stephen, Watson‐Fargie, Taylor, Evangelista, Teresinha, Sansone, Valeria, Nesbitt, Victoria, Macken, William L., Oktay, Yavuz

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