Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers von Houang, Evelyne M, Sham, Yuk Y, Bates, Frank S, Metzger, Joseph M

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Molecular Determinants of Cardiac Myocyte Performance as Conferred by Isoform-Specific TnI Residues von Thompson, Brian R., Houang, Evelyne M., Sham, Yuk Y., Metzger, Joseph M.

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Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury von Houang, Evelyne M., PhD, Bartos, Jason, MD, Hackel, Benjamin J., PhD, Lodge, Timothy P., PhD, Yannopoulos, Demetris, MD, Bates, Frank S., ScD, Metzger, Joseph M., PhD

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pH-Responsive Titratable Inotropic Performance of Histidine-Modified Cardiac Troponin I von Palpant, Nathan J., Houang, Evelyne M., Sham, Yuk Y., Metzger, Joseph M.

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Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo von Houang, Evelyne M, Haman, Karen J, Filareto, Antonio, Perlingeiro, Rita C, Bates, Frank S, Lowe, Dawn A, Metzger, Joseph M

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All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions von Houang, Evelyne M, Bates, Frank S, Sham, Yuk Y, Metzger, Joseph M

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AutoDesigner, a De Novo Design Algorithm for Rapidly Exploring Large Chemical Space for Lead Optimization: Application to the Design and Synthesis of d‑Amino Acid Oxidase Inhibitor... von Bos, Pieter H, Houang, Evelyne M, Ranalli, Fabio, Leffler, Abba E, Boyles, Nicholas A, Eyrich, Volker A, Luria, Yuval, Katz, Dana, Tang, Haifeng, Abel, Robert, Bhat, Sathesh

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PEO–PPO Diblock Copolymers Protect Myoblasts from Hypo-Osmotic Stress In Vitro Dependent on Copolymer Size, Composition, and Architecture von Kim, Mihee, Haman, Karen J, Houang, Evelyne M, Zhang, Wenjia, Yannopoulos, Demetris, Metzger, Joseph M, Bates, Frank S, Hackel, Benjamin J

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TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility von Vetter, Anthony D., Houang, Evelyne M., Sell, Jordan J., Thompson, Brian R., Sham, Yuk Y., Metzger, Joseph M.

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Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization von Houang, Evelyne M, Haman, Karen J, Kim, Mihee, Zhang, Wenjia, Lowe, Dawn A, Sham, Yuk Y, Lodge, Timothy P, Hackel, Benjamin J, Bates, Frank S, Metzger, Joseph M

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Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations von Palpant, Nathan J, Houang, Evelyne M, Delport, Wayne, Hastings, Kenneth E M, Onufriev, Alexey V, Sham, Yuk Y, Metzger, Joseph M

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Membrane-Sealant Copolymers Confer Protection to Dystrophic Skeletal Muscle in Vitro and in Vivo von Houang, Evelyne M., Haman, Karen, Bates, Frank, Lowe, Dawn A., Metzger, Joseph M.

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Structure-Function of Synthetic Membrane-Sealant Copolymers for Dystrophic Muscle von Houang, Evelyne M., Haman, Karen, Bates, Frank S., Metzger, Joseph M.

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Computational Studies of a pH Responsive Histidine-Modified Cardiac Troponin I von Houang, Evelyne M., Palpant, Nathan J., Sham, Yuk Y., Metzger, Joseph M.

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Figure 4: Copolymer-Muscle Membrane Interface von Houang, Evelyne M., Bartos, Jason, Hackel, Benjamin J., Lodge, Timothy P., Demetris Yannopoulos, Bates, Frank S., Metzger, Joseph M.

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Figure 2: Schematic Representation of Block Copolymer P188 Interaction With the Cardiac Sarcolemma von Houang, Evelyne M., Bartos, Jason, Hackel, Benjamin J., Lodge, Timothy P., Demetris Yannopoulos, Bates, Frank S., Metzger, Joseph M.

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Figure 1: Health Relevance von Houang, Evelyne M., Bartos, Jason, Hackel, Benjamin J., Lodge, Timothy P., Demetris Yannopoulos, Bates, Frank S., Metzger, Joseph M.

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Central Illustration: Chemical-Based Membrane Stabilizer Discovery Platform Integrating Insights From Vesicles to In Vivo von Houang, Evelyne M., Bartos, Jason, Hackel, Benjamin J., Lodge, Timothy P., Demetris Yannopoulos, Bates, Frank S., Metzger, Joseph M.

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Discovery of a Novel Class of d‑Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform von Tang, Haifeng, Jensen, Kristian, Houang, Evelyne, McRobb, Fiona M., Bhat, Sathesh, Svensson, Mats, Bochevarov, Art, Day, Tyler, Dahlgren, Markus K., Bell, Jeffery A., Frye, Leah, Skene, Robert J., Lewis, James H., Osborne, James D., Tierney, Jason P., Gordon, James A., Palomero, Maria A., Gallati, Caroline, Chapman, Robert S. L., Jones, Daniel R., Hirst, Kim L., Sephton, Mark, Chauhan, Alka, Sharpe, Andrew, Tardia, Piero, Dechaux, Elsa A., Taylor, Andrea, Waddell, Ross D., Valentine, Andrea, Janssens, Holden B., Aziz, Omar, Bloomfield, Dawn E., Ladha, Sandeep, Fraser, Ian J., Ellard, John M.

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Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform von Tang, Haifeng, Jensen, Kristian, Houang, Evelyne, McRobb, Fiona M, Bhat, Sathesh, Svensson, Mats, Bochevarov, Art, Day, Tyler, Dahlgren, Markus K, Bell, Jeffery A, Frye, Leah, Skene, Robert J, Lewis, James H, Osborne, James D, Tierney, Jason P, Gordon, James A, Palomero, Maria A, Gallati, Caroline, Chapman, Robert S L, Jones, Daniel R, Hirst, Kim L, Sephton, Mark, Chauhan, Alka, Sharpe, Andrew, Tardia, Piero, Dechaux, Elsa A, Taylor, Andrea, Waddell, Ross D, Valentine, Andrea, Janssens, Holden B, Aziz, Omar, Bloomfield, Dawn E, Ladha, Sandeep, Fraser, Ian J, Ellard, John M

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