Five-Year Outcomes of Wide Excision and Mohs Micrographic Surgery for Primary Lentigo Maligna in an Academic Practice Cohort von Hou, Jennifer L, Reed, Kurtis B, Knudson, Richelle M, Mirzoyev, Sultan A, Lohse, Christine M, Frohm, Marcus L, Brewer, Jerry D, Otley, Clark C, Roenigk, Randall K

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Characteristics of Sebaceous Carcinoma and Early Outcomes of Treatment Using Mohs Micrographic Surgery Versus Wide Local Excision: An Update of the Mayo Clinic Experience Over the... von Hou, Jennifer L., Killian, Jill M., Baum, Christian L., Otley, Clark C., Roenigk, Randall K., Arpey, Christopher J., Weaver, Amy L., Brewer, Jerry D.

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Incidence of lentigo maligna in Olmsted County, Minnesota, 1970 to 2007 von Mirzoyev, Sultan A, Knudson, Richelle M., MD, Reed, Kurtis B., MD, Hou, Jennifer L, Lohse, Christine M, Frohm, Marcus L., MD, Brewer, Jerry D., MD, Otley, Clark C., MD, Roenigk, Randall K., MD

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Senolytics improve physical function and increase lifespan in old age von Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.

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s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways von Ding, Wei, Smulan, Lorissa J., Hou, Nicole S., Taubert, Stefan, Watts, Jennifer L., Walker, Amy K.

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Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo von Hou, Nicole S, Gutschmidt, Aljona, Choi, Daniel Y, Pather, Keouna, Shi, Xun, Watts, Jennifer L, Hoppe, Thorsten, Taubert, Stefan

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Human pluripotent stem cell-derived neural constructs for predicting neural toxicity von Schwartz, Michael P., Hou, Zhonggang, Propson, Nicholas E., Zhang, Jue, Engstrom, Collin J., Costa, Vitor Santos, Jiang, Peng, Nguyen, Bao Kim, Bolin, Jennifer M., Daly, William, Wang, Yu, Stewart, Ron, Page, C. David, Murphy, William L., Thomson, James A.

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CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer von Nie, Lei, Wei, Yongkun, Zhang, Fei, Hsu, Yi-Hsin, Chan, Li-Chuan, Xia, Weiya, Ke, Baozhen, Zhu, Cihui, Deng, Rong, Tang, Jun, Yao, Jun, Chu, Yu-Yi, Zhao, Xixi, Han, Ye, Hou, Junwei, Huo, Longfei, Ko, How-Wen, Lin, Wan-Chi, Yamaguchi, Hirohito, Hsu, Jung-Mao, Yang, Yi, Pan, Dean N., Hsu, Jennifer L., Kleer, Celina G., Davidson, Nancy E., Hortobagyi, Gabriel N., Hung, Mien-Chie

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NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency von Hou, Yujun, Lautrup, Sofie, Cordonnier, Stephanie, Wang, Yue, Croteau, Deborah L., Zavala, Eduardo, Zhang, Yongqing, Moritoh, Kanako, O’Connell, Jennifer F., Baptiste, Beverly A., Stevnsner, Tinna V., Mattson, Mark P., Bohr, Vilhelm A.

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Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 von O’Brien, Meagan P, Forleo-Neto, Eduardo, Musser, Bret J, Isa, Flonza, Chan, Kuo-Chen, Sarkar, Neena, Bar, Katharine J, Barnabas, Ruanne V, Barouch, Dan H, Cohen, Myron S, Hurt, Christopher B, Burwen, Dale R, Marovich, Mary A, Hou, Peijie, Heirman, Ingeborg, Davis, John D, Turner, Kenneth C, Ramesh, Divya, Mahmood, Adnan, Hooper, Andrea T, Hamilton, Jennifer D, Kim, Yunji, Purcell, Lisa A, Baum, Alina, Kyratsous, Christos A, Krainson, James, Perez-Perez, Richard, Mohseni, Rizwana, Kowal, Bari, DiCioccio, A. Thomas, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary, Yancopoulos, George D, Weinreich, David M

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Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer von Sternberg, Cora N, Fizazi, Karim, Saad, Fred, Shore, Neal D, De Giorgi, Ugo, Penson, David F, Ferreira, Ubirajara, Efstathiou, Eleni, Madziarska, Katarzyna, Kolinsky, Michael P, Cubero, Daniel I. G, Noerby, Bettina, Zohren, Fabian, Lin, Xun, Modelska, Katharina, Sugg, Jennifer, Steinberg, Joyce, Hussain, Maha

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Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase‐dependent pathways towards changing environments von Timm, Stefan, Klaas, Nicole, Niemann, Janice, Jahnke, Kathrin, Alseekh, Saleh, Zhang, Youjun, Souza, Paulo V. L., Hou, Liang‐Yu, Cosse, Maike, Selinski, Jennifer, Geigenberger, Peter, Daloso, Danilo M., Fernie, Alisdair R., Hagemann, Martin

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Loss-of-Function Alanyl-tRNA Synthetase Mutations Cause an Autosomal-Recessive Early-Onset Epileptic Encephalopathy with Persistent Myelination Defect von Simons, Cas, Griffin, Laurie B., Helman, Guy, Golas, Gretchen, Pizzino, Amy, Bloom, Miriam, Murphy, Jennifer L.P., Crawford, Joanna, Evans, Sarah H., Topper, Scott, Whitehead, Matthew T., Schreiber, John M., Chapman, Kimberly A., Tifft, Cyndi, Lu, Katrina B., Gamper, Howard, Shigematsu, Megumi, Taft, Ryan J., Antonellis, Anthony, Hou, Ya-Ming, Vanderver, Adeline

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Dietary quality and the colonic mucosa–associated gut microbiome in humans von Liu, Yanhong, Ajami, Nadim J, El-Serag, Hashem B, Hair, Clark, Graham, David Y, White, Donna L, Chen, Liang, Wang, Zhensheng, Plew, Sarah, Kramer, Jennifer, Cole, Rhonda, Hernaez, Ruben, Hou, Jason, Husain, Nisreen, Jarbrink-Sehgal, Maria E, Kanwal, Fasiha, Ketwaroo, Gyanprakash, Natarajan, Yamini, Shah, Rajesh, Velez, Maria, Mallepally, Niharika, Petrosino, Joseph F, Jiao, Li

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Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype von Luc, Sidinh, Huang, Jialiang, McEldoon, Jennifer L., Somuncular, Ece, Li, Dan, Rhodes, Claire, Mamoor, Shahan, Hou, Serena, Xu, Jian, Orkin, Stuart H.

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Palmitoylation stabilizes PD-L1 to promote breast tumor growth von Yang, Yi, Hsu, Jung-Mao, Sun, Linlin, Chan, Li-Chuan, Li, Chia-Wei, Hsu, Jennifer L., Wei, Yongkun, Xia, Weiya, Hou, Junwei, Qiu, Yufan, Hung, Mien-Chie

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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics von Luecken, Malte D., Sikkema, Lisa, Waghray, Avinash, Heimberg, Graham, Kobayashi, Yoshihiko, Vaishnav, Eeshit Dhaval, Subramanian, Ayshwarya, Smillie, Christopher, Jagadeesh, Karthik A., Duong, Elizabeth Thu, Torlai Triglia, Elena, Ansari, Meshal, Cai, Peiwen, Lin, Brian, Chen, Sijia, Shu, Jian, Haber, Adam L., Chung, Hattie, Montoro, Daniel T., Adams, Taylor, Aliee, Hananeh, Andrusivova, Zaneta, Angelidis, Ilias, Ashenberg, Orr, Bassler, Kevin, Bécavin, Christophe, Benhar, Inbal, Bergenstråhle, Joseph, Bergenstråhle, Ludvig, Braun, Emelie, Bui, Linh T., Chaffin, Mark, Chichelnitskiy, Evgeny, Chiou, Joshua, Conlon, Thomas M., Cuoco, Michael S., Cuomo, Anna S. E., Deprez, Marie, Duclos, Grant, Fischer, David S., Ghazanfar, Shila, Gillich, Astrid, Giotti, Bruno, Gould, Joshua, Guo, Minzhe, Gutierrez, Austin J., Habermann, Arun C., Harvey, Tyler, He, Peng, Hou, Xiaomeng, Hu, Yan, Jaiswal, Alok, Ji, Lu, Jiang, Peiyong, Kapellos, Theodoros S., Kuo, Christin S., Leney-Greene, Michael A., Lim, Kyungtae, Litviňuková, Monika, Ludwig, Leif S., Lukassen, Soeren, Luo, Wendy, Maatz, Henrike, Madissoon, Elo, Mamanova, Lira, Manakongtreecheep, Kasidet, Leroy, Sylvie, Mayr, Christoph H., McAdams, Alexi M., Nabhan, Ahmad N., Nyquist, Sarah K., Penland, Lolita, Poirion, Olivier B., Poli, Sergio, Qi, CanCan, Queen, Rachel, Reichart, Daniel, Rosas, Ivan, Schupp, Jonas C., Shea, Conor V., Shi, Xingyi, Sinha, Rahul, Slowikowski, Kamil, Smith, Neal P., Sountoulidis, Alex, Strunz, Maximilian, Sullivan, Travis B., Sun, Dawei, Talavera-López, Carlos, Tan, Peng, Tantivit, Jessica, Travaglini, Kyle J., Tucker, Nathan R., Vernon, Katherine A., Wadsworth, Marc H., Waldman, Julia, Wang, Xiuting, Yan, Wenjun, Zhao, William, Ziegler, Carly G. K.

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Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity von Tsai, James, Lee, John T., Wang, Weiru, Zhang, Jiazhong, Cho, Hanna, Mamo, Shumeye, Bremer, Ryan, Gillette, Sam, Kong, Jun, Haass, Nikolas K., Sproesser, Katrin, Li, Ling, Smalley, Keiran S. M., Fong, Daniel, Zhu, Yong-Liang, Marimuthu, Adhirai, Nguyen, Hoa, Lam, Billy, Liu, Jennifer, Cheung, Ivana, Rice, Julie, Suzuki, Yoshihisa, Luu, Catherine, Settachatgul, Calvin, Shellooe, Rafe, Cantwell, John, Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y. J., West, Brian L., Powell, Ben, Habets, Gaston, Zhang, Chao, Ibrahim, Prabha N., Hirth, Peter, Artis, Dean R., Herlyn, Meenhard, Bollag, Gideon

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FDA Approval Summary: Atezolizumab Plus Paclitaxel Protein-bound for the Treatment of Patients with Advanced or Metastatic TNBC Whose Tumors Express PD-L1 von Narayan, Preeti, Wahby, Sakar, Gao, Jennifer J., Amiri-Kordestani, Laleh, Ibrahim, Amna, Bloomquist, Erik, Tang, Shenghui, Xu, Yuan, Liu, Jiang, Fu, Wentao, Song, Pengfei, King-Kallimanis, Bellinda L., Hou, Sherry, Gong, Yutao, Kalavar, Shyam, Ghosh, Soma, Philip, Reena, Goldberg, Kirsten B., Theoret, Marc R., Blumenthal, Gideon M., Kluetz, Paul Gustav, Sridhara, Rajeshwari, Pazdur, Richard, Beaver, Julia A.

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T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial von Ewer, Katie J., Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Sharpe, Hannah, Makinson, Rebecca, Morter, Richard, Flaxman, Amy, Wright, Daniel, Bellamy, Duncan, Bittaye, Mustapha, Dold, Christina, Provine, Nicholas M., Aboagye, Jeremy, Fowler, Jamie, Silk, Sarah E., Alderson, Jennifer, Aley, Parvinder K., Angus, Brian, Berrie, Eleanor, Bibi, Sagida, Cicconi, Paola, Clutterbuck, Elizabeth A., Chelysheva, Irina, Folegatti, Pedro M., Fuskova, Michelle, Green, Catherine M., Jenkin, Daniel, Kerridge, Simon, Lawrie, Alison, Minassian, Angela M., Moore, Maria, Mujadidi, Yama, Plested, Emma, Poulton, Ian, Ramasamy, Maheshi N., Robinson, Hannah, Song, Rinn, Snape, Matthew D., Tarrant, Richard, Voysey, Merryn, Watson, Marion E. E., Douglas, Alexander D., Hill, Adrian V. S., Gilbert, Sarah C., Pollard, Andrew J., Lambe, Teresa

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