Abstract 42: Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer von Son, Thomas, Scribner, Juniper A., Hooley, Jeff, Chiechi, Michael, Li, Pam, Hotaling, Timothy E., Costa, Anushka De, Chen, Yan, Chen, Francine, Barat, Bhaswati, Ciccarone, Valentina, Gaynutdinov, Timur, Tamura, James, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio, Loo, Deryk

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Abstract 38: Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumors von Scribner, Juniper A., Barat, Bhaswati, Hicks, Stuart W., Yoder, Nicholas C., Son, Thomas, Widjaja, Lusiana, Diedrich, Gundo, Gorlatov, Sergey, Hooley, Jeff, Easton, Ann, Lung, Peter, Costa, Anushka De, Chen, Francine, Chiechi, Michael, Li, Pam, Licea, Monica, Hotaling, Timothy E., Spliedt, Michael, Ciccarone, Valentina, Gantt, Nadia, Tamura, James, Fuller, Megan E., McShea, Molly, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio, Loo, Deryk

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Abstract 1201: Anti-B7-H3 antibody-drug conjugates as potential therapeutics for solid cancer von Loo, Deryk, Scribner, Juniper A., Son, Thomas, Hooley, Jeff, Hotaling, Timothy, Chiechi, Michael, Li, Pam, De Costa, Anushka, Chen, Yan, Easton, Ann, Chen, Francine Z., Barat, Bhaswati, Ciccarone, Valentina, Tamura, James, Kubik, Mark, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio

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X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: Structural indications of the key role of VH residues 59 to 65 von Eigenbrot, Charles, Gonzalez, Tania, Mayeda, Julia, Carter, Paul, Werther, Winifred, Hotaling, Timothy, Fox, Judy, Kessler, Jeremy

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Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1 von Werther, WA, Gonzalez, TN, O'Connor, SJ, McCabe, S, Chan, B, Hotaling, T, Champe, M, Fox, JA, Jardieu, PM, Berman, PW, Presta, LG

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Secretion of glycosylation site mutants can be rescued by the signal/pro sequence of tissue plasminogen activator von Köhne, Christiane, Johnson, Adriana, Tom, Sabrina, Peers, David H., Gehant, Richard L., Hotaling, Timothy A., Brousseau, Dave, Ryll, Thomas, Fox, Judith A., Chamow, Steven M., Berman, Phillip W.

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X‐ray structures of fragments from binding and nonbinding versions of a humanized anti‐CD18 antibody: Structural indications of the key role of V H residues 59 to 65 von Eigenbrot, Charles, Gonzalez, Tania, Mayeda, Julia, Carter, Paul, Werther, Winifred, Hotaling, Timothy, Fox, Judy, Kessler, Jeremy

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Decreased fecundity and sperm DNA methylation patterns von Jenkins, Timothy G., Ph.D, Aston, Kenneth I., Ph.D, Meyer, Tyson D., B.S, Hotaling, James M., M.D., M.S, Shamsi, Monis B., Ph.D, Johnstone, Erica B., M.D, Cox, Kyley J., M.P.H, Stanford, Joseph B., M.D., M.S.P.H, Porucznik, Christina A., Ph.D., M.S.P.H, Carrell, Douglas T., Ph.D

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Diverse monogenic subforms of human spermatogenic failure von Nagirnaja, Liina, Lopes, Alexandra M., Charng, Wu-Lin, Miller, Brian, Stakaitis, Rytis, Golubickaite, Ieva, Stendahl, Alexandra, Luan, Tianpengcheng, Friedrich, Corinna, Mahyari, Eisa, Fadial, Eloise, Kasak, Laura, Vigh-Conrad, Katinka, Oud, Manon S., Xavier, Miguel J., Cheers, Samuel R., James, Emma R., Guo, Jingtao, Jenkins, Timothy G., Riera-Escamilla, Antoni, Barros, Alberto, Carvalho, Filipa, Fernandes, Susana, Gonçalves, João, Gurnett, Christina A., Jørgensen, Niels, Jezek, Davor, Jungheim, Emily S., Kliesch, Sabine, McLachlan, Robert I., Omurtag, Kenan R., Pilatz, Adrian, Sandlow, Jay I., Smith, James, Eisenberg, Michael L., Hotaling, James M., Jarvi, Keith A., Punab, Margus, Rajpert-De Meyts, Ewa, Carrell, Douglas T., Krausz, Csilla, Laan, Maris, O’Bryan, Moira K., Schlegel, Peter N., Tüttelmann, Frank, Veltman, Joris A., Almstrup, Kristian, Aston, Kenneth I., Conrad, Donald F.

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NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure von Murphy, Patrick J, Guo, Jingtao, Jenkins, Timothy G, James, Emma R, Hoidal, John R, Huecksteadt, Thomas, Broberg, Dallin S, Hotaling, James M, Alonso, David F, Carrell, Douglas T, Cairns, Bradley R, Aston, Kenneth I

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Obesity, male infertility, and the sperm epigenome von Craig, James, M.D, Jenkins, Timothy G., Ph.D, Carrell, Douglas T., Ph.D., H.C.L.D, Hotaling, James M., M.D., M.S., F.E.C.S.M

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Diagnosis and Management of Infantile Hemangioma von Darrow, David H, Greene, Arin K, Mancini, Anthony J, Nopper, Amy J

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Proton-pump inhibitor use does not affect semen quality in subfertile men von Keihani, Sorena, Craig, James, Zhang, Chong, Presson, Angela, Myers, Jeremy, Brant, William, Aston, Kenneth, Emery, Benjamin, Jenkins, Timothy, Carrell, Douglas, Hotaling, James

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Specialized meltwater biodiversity persists despite widespread deglaciation von Muhlfeld, Clint C., Cline, Timothy J., Giersch, J. Joseph, Peitzsch, Erich, Florentine, Caitlyn, Jacobsen, Dean, Hotaling, Scott

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Intra-sample heterogeneity of sperm DNA methylation von Jenkins, Timothy G, Aston, Kenneth I, Trost, Cooper, Farley, Jordan, Hotaling, James M, Carrell, Douglas T

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Microfluidic System for Rapid Isolation of Sperm From Microdissection TESE Specimens von Samuel, Raheel, Son, Jiyoung, Jenkins, Timothy G., Jafek, Alexander, Feng, Haidong, Gale, Bruce K., Carrell, Douglas T., Hotaling, James M.

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Contemporary management of high-grade renal trauma: Results from the American Association for the Surgery of Trauma Genitourinary Trauma study von Keihani, Sorena, Xu, Yizhe, Presson, Angela P, Hotaling, James M, Nirula, Raminder, Piotrowski, Joshua, Dodgion, Christopher M, Black, Cullen M, Mukherjee, Kaushik, Morris, Bradley J, Majercik, Sarah, Smith, Brian P, Schwartz, Ian, Elliott, Sean P, DeSoucy, Erik S, Zakaluzny, Scott, Thomsen, Peter B, Erickson, Bradley A, Baradaran, Nima, Breyer, Benjamin N, Miller, Brandi, Santucci, Richard A, Carrick, Matthew M, Hewitt, Timothy, Burks, Frank N, Kocik, Jurek F, Askari, Reza, Myers, Jeremy B

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Age-associated sperm DNA methylation patterns do not directly persist trans-generationally von Jenkins, Timothy G, James, Emma R, Aston, Kenneth I, Salas-Huetos, Albert, Pastuszak, Alexander W, Smith, Ken R, Hanson, Heidi A, Hotaling, James M, Carrell, Douglas T

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MicroRNA: a step beyond bulk seminal parameters? von Hotaling, James M., M.D., M.S, Jenkins, Timothy G., Ph.D

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Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia von Salas-Huetos, Albert, Tüttelmann, Frank, Wyrwoll, Margot J., Kliesch, Sabine, Lopes, Alexandra M., Goncalves, João, Boyden, Steven E., Wöste, Marius, Hotaling, James M., Nagirnaja, Liina, Conrad, Donald F., Carrell, Douglas T., Aston, Kenneth I.

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