Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art von Hostetler, Karl Y.

Volltext

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs von Schooley, Robert T, Carlin, Aaron F, Beadle, James R, Valiaeva, Nadejda, Zhang, Xing-Quan, Clark, Alex E, McMillan, Rachel E, Leibel, Sandra L, McVicar, Rachael N, Xie, Jialei, Garretson, Aaron F, Smith, Victoria I, Murphy, Joyce, Hostetler, Karl Y

Volltext

Synthesis and Early Development of Hexadecyloxypropyl-cidofovir: An Oral Antipoxvirus Nucleoside Phosphonate von Hostetler, Karl Y.

Volltext

Teacher as Tragic Ironist von Hostetler, Karl D.

Volltext

Application of kinase bypass strategies to nucleoside antivirals von Ray, Adrian S., Hostetler, Karl Y.

Volltext

1‑O‑Octadecyl-2‑O‑benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV‑2 Infection and Synthesis and Antiviral Evaluation of Additi... von Carlin, Aaron F., Beadle, James R., Clark, Alex E., Gully, Kendra L., Moreira, Fernando R., Baric, Ralph S., Graham, Rachel L., Valiaeva, Nadejda, Leibel, Sandra L., Bray, William, McMillan, Rachel E., Freshman, Jonathan E., Garretson, Aaron F., McVicar, Rachael N., Rana, Tariq, Zhang, Xing-Quan, Murphy, Joyce A., Schooley, Robert T., Hostetler, Karl Y.

Volltext

Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524) von Lo, Michael K, Shrivastava-Ranjan, Punya, Chatterjee, Payel, Flint, Mike, Beadle, James R, Valiaeva, Nadejda, Murphy, Joyce, Schooley, Robert T, Hostetler, Karl Y, Montgomery, Joel M, Spiropoulou, Christina F

Volltext

Beyond Reflection: Perception, virtue, and teacher knowledge von Hostetler, Karl D.

Volltext

Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs von McMillan, Rachel E., Lo, Michael K., Zhang, Xing-Quan, Beadle, James R., Valiaeva, Nadejda, Garretson, Aaron F., Clark, Alex E., Freshman, Jon E., Murphy, Joyce, Montgomery, Joel M., Spiropoulou, Christina F., Schooley, Robert T., Hostetler, Karl Y., Carlin, Aaron F.

Volltext

Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system von Ma, Feiyan, Nan, Kaihui, Lee, SuNa, Beadle, James R., Hou, Huiyuan, Freeman, William R., Hostetler, Karl Y., Cheng, Lingyun

Volltext

Cidofovir and (S)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand von MAGEE, Wendy C, ALDERN, Kathy A, HOSTETLER, Karl Y, EVANS, David H

Volltext

Octadecyloxyethyl benzyl tenofovir: A novel tenofovir diester provides sustained intracellular levels of tenofovir diphosphate von Beadle, James R., Aldern, Kathy A., Zhang, Xing-Quan, Valiaeva, Nadejda, Hostetler, Karl Y., Schooley, Robert T.

Volltext

Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate von MAGEE, Wendy C, HOSTELLER, Karl Y, EVANS, David H

Volltext

Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro von Hartline, Caroll B., Gustin, Kortney M., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R

Volltext

Evaluation of ODE-Bn-PMEG, an acyclic nucleoside phosphonate prodrug, as an antiviral against productive HPV infection in 3D organotypic epithelial cultures von Banerjee, N. Sanjib, Wang, Hsu-Kun, Beadle, James R., Hostetler, Karl Y., Chow, Louise T.

Volltext

Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia von Khoury, Haytham, He, Ruijuan, Schimmer, Aaron, Beadle, James R., Hostetler, Karl Y., Minden, Mark D.

Volltext

Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9‑[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification von Beadle, James R, Valiaeva, Nadejda, Yang, Guang, Yu, Jei-Hwa, Broker, Thomas R, Aldern, Kathy A, Harden, Emma A, Keith, Kathy A, Prichard, Mark N, Hartman, Tracy, Buckheit, Robert W, Chow, Louise T, Hostetler, Karl Y

Volltext

Ether Lipid Ester Derivatives of Cidofovir Inhibit Polyomavirus BK Replication In Vitro von RANDHAWA, Parmjeet, FARASATI, Noush Afarin, SHAPIRO, Ron, HOSTETLER, Karl Y

Volltext

Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir von KERN, Earl R, HARTLINE, Caroll, HARDEN, Emma, KEITH, Kathy, RODRIGUEZ, Natalie, BEADLE, James R, HOSTETLER, Karl Y

Volltext

Inhibition of adenovirus serotype 14 infection by octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- nucleosides in vitro von Kumaki, Yohichi, Woolcott, John D., Roth, Jason P., Mclean, Tyler Z., Smee, Donald F., Barnard, Dale L., Valiaeva, Nadejda, Beadle, James R., Hostetler, Karl Y.

Volltext