Overcoming mutation-based resistance to antiandrogens with rational drug design von Balbas, Minna D, Evans, Michael J, Hosfield, David J, Wongvipat, John, Arora, Vivek K, Watson, Philip A, Chen, Yu, Greene, Geoffrey L, Shen, Yang, Sawyers, Charles L

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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells von Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L

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Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer von West, Diana C, Kocherginsky, Masha, Tonsing-Carter, Eva Y, Dolcen, D Nesli, Hosfield, David J, Lastra, Ricardo R, Sinnwell, Jason P, Thompson, Kevin J, Bowie, Kathleen R, Harkless, Ryan V, Skor, Maxwell N, Pierce, Charles F, Styke, Sarah C, Kim, Caroline R, de Wet, Larischa, Greene, Geoffrey L, Boughey, Judy C, Goetz, Matthew P, Kalari, Krishna R, Wang, Liewei, Fleming, Gini F, Györffy, Balázs, Conzen, Suzanne D

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Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells von Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Suavage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Nduwke, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W

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Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair von Chapados, Brian R, Hosfield, David J, Han, Seungil, Qiu, Junzhuan, Yelent, Biana, Shen, Binghui, Tainer, John A

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Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase[boxs] von Garcin, Elsa D., Bruns, Christopher M., Lloyd, Sarah J., Hosfield, David J., Tiso, Mauro, Gachhui, Ratan, Stuehr, Dennis J., Tainer, John A., Getzoff, Elizabeth D.

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Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis von Hosfield, David J., Zhang, Yanming, Dougan, Douglas R., Broun, Alexei, Tari, Leslie W., Swanson, Ronald V., Finn, John

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Structure-based design and discovery of potent and selective KDM5 inhibitors von Nie, Zhe, Shi, Lihong, Lai, Chon, O'Connell, Shawn M., Xu, Jiangchun, Stansfield, Ryan K., Hosfield, David J., Veal, James M., Stafford, Jeffrey A.

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Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes von Tsutakawa, Susan E., Shin, David S., Mol, Clifford D., Izumi, Tadahide, Arvai, Andrew S., Mantha, Anil K., Szczesny, Bartosz, Ivanov, Ivaylo N., Hosfield, David J., Maiti, Buddhadev, Pique, Mike E., Frankel, Kenneth A., Hitomi, Kenichi, Cunningham, Richard P., Mitra, Sankar, Tainer, John A.

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Discovery and characterization of novel allosteric FAK inhibitors von Iwatani, Misa, Iwata, Hidehisa, Okabe, Atsutoshi, Skene, Robert J., Tomita, Naoki, Hayashi, Yoko, Aramaki, Yoshio, Hosfield, David J., Hori, Akira, Baba, Atsuo, Miki, Hiroshi

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Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors von Bennett, Michael J., Wu, Yiqin, Boloor, Amogh, Matuszkiewicz, Jennifer, O'Connell, Shawn M., Shi, Lihong, Stansfield, Ryan K., Del Rosario, Joselyn R., Veal, James M., Hosfield, David J., Xu, Jiangchun, Kaldor, Stephen W., Stafford, Jeffrey A., Betancort, Juan M.

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Structure-based discovery of cellular-active allosteric inhibitors of FAK von Tomita, Naoki, Hayashi, Yoko, Suzuki, Shinkichi, Oomori, Yoshimasa, Aramaki, Yoshio, Matsushita, Yoshihiro, Iwatani, Misa, Iwata, Hidehisa, Okabe, Atsutoshi, Awazu, Yoshiko, Isono, Osamu, Skene, Robert J., Hosfield, David J., Miki, Hiroshi, Kawamoto, Tomohiro, Hori, Akira, Baba, Atsuo

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models von Chen, Young K, Bonaldi, Tiziana, Cuomo, Alessandro, Del Rosario, Joselyn R, Hosfield, David J, Kanouni, Toufike, Kao, Shih-chu, Lai, Chon, Lobo, Neethan A, Matuszkiewicz, Jennifer, McGeehan, Andrew, O’Connell, Shawn M, Shi, Lihong, Stafford, Jeffrey A, Stansfield, Ryan K, Veal, James M, Weiss, Michael S, Yuen, Natalie Y, Wallace, Michael B

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DNA apurinic-apyrimidinic site binding and excision by endonuclease IV von Garcin, Elsa D, Hosfield, David J, Desai, Sunil A, Haas, Brian J, Björas, Magnar, Cunningham, Richard P, Tainer, John A

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Crystal Structure of Pasteurella haemolytica Ferric Ion-binding Protein A Reveals a Novel Class of Bacterial Iron-binding Proteins von Shouldice, Stephen R., Dougan, Douglas R., Williams, Pamela A., Skene, Robert J., Snell, Gyorgy, Scheibe, Daniel, Kirby, Shane, Hosfield, David J., McRee, Duncan E., Schryvers, Anthony B., Tari, Leslie W.

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Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1: Coupling DNA and PCNA Binding to FEN-1 Activity von Hosfield, David J, Mol, Clifford D, Shen, Binghui, Tainer, John A

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Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication von Chapados, Brian R, Chai, Qing, Hosfield, David J, Qiu, Junzhuan, Shen, Binghui, Tainer, John A

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Envisioning the molecular choreography of DNA base excision repair von Parikh, Sudip S, Mol, Clifford D, Hosfield, David J, Tainer, John A

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Newly Discovered Archaebacterial Flap Endonucleases Show a Structure-Specific Mechanism for DNA Substrate Binding and Catalysis Resembling Human Flap Endonuclease-1 von Hosfield, David J., Frank, Geoffrey, Weng, Yehua, Tainer, John A., Shen, Binghui

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Structure of the DNA Repair Enzyme Endonuclease IV and Its DNA Complex: Double-Nucleotide Flipping at Abasic Sites and Three-Metal-Ion Catalysis von Hosfield, David J., Guan, Yue, Haas, Brian J., Cunningham, Richard P., Tainer, John A.

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