MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease von Balusu, Sriram, Horré, Katrien, Thrupp, Nicola, Craessaerts, Katleen, Snellinx, An, Serneels, Lutgarde, T’Syen, Dries, Chrysidou, Iordana, Arranz, Amaia M., Sierksma, Annerieke, Simrén, Joel, Karikari, Thomas K., Zetterberg, Henrik, Chen, Wei-Ting, Thal, Dietmar Rudolf, Salta, Evgenia, Fiers, Mark, De Strooper, Bart

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Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease von Walgrave, Hannah, Balusu, Sriram, Snoeck, Sarah, Vanden Eynden, Elke, Craessaerts, Katleen, Thrupp, Nicky, Wolfs, Leen, Horré, Katrien, Fourne, Yannick, Ronisz, Alicja, Silajdžić, Edina, Penning, Amber, Tosoni, Giorgia, Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Thal, Dietmar Rudolf, Zetterberg, Henrik, Thuret, Sandrine, Fiers, Mark, Frigerio, Carlo Sala, De Strooper, Bart, Salta, Evgenia

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Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions von Szaruga, Maria, Munteanu, Bogdan, Lismont, Sam, Veugelen, Sarah, Horré, Katrien, Mercken, Marc, Saido, Takaomi C., Ryan, Natalie S., De Vos, Tatjana, Savvides, Savvas N., Gallardo, Rodrigo, Schymkowitz, Joost, Rousseau, Frederic, Fox, Nick C., Hopf, Carsten, De Strooper, Bart, Chávez-Gutiérrez, Lucía

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β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease von Thathiah, Amantha, Horré, Katrien, Snellinx, An, Vandewyer, Elke, Huang, Yunhong, Ciesielska, Marta, De Kloe, Gerdien, Munck, Sebastian, De Strooper, Bart

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Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease von Shah, Disha, Gsell, Willy, Wahis, Jérôme, Luckett, Emma S., Jamoulle, Tarik, Vermaercke, Ben, Preman, Pranav, Moechars, Daan, Hendrickx, Véronique, Jaspers, Tom, Craessaerts, Katleen, Horré, Katrien, Wolfs, Leen, Fiers, Mark, Holt, Matthew, Thal, Dietmar Rudolf, Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Vandenberghe, Rik, Himmelreich, Uwe, Bonin, Vincent, De Strooper, Bart

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PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome von Spinazzi, Marco, Radaelli, Enrico, Horré, Katrien, Arranz, Amaia M., Gounko, Natalia V., Agostinis, Patrizia, Maia, Teresa Mendes, Impens, Francis, Moraisi, Vanessa Alexandra, Lopez-Lluch, Guillermo, Serneels, Lutgarde, Navas, Placido, De Strooper, Bart

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Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms von Bentahir, Mostafa, Nyabi, Omar, Verhamme, Jan, Tolia, Alexandra, Horré, Katrien, Wiltfang, Jens, Esselmann, Hermann, Strooper, Bart

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Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions von Prox, Johannes, Bernreuther, Christian, Altmeppen, Hermann, Grendel, Jasper, Glatzel, Markus, D'Hooge, Rudi, Stroobants, Stijn, Ahmed, Tariq, Balschun, Detlef, Willem, Michael, Lammich, Sven, Isbrandt, Dirk, Schweizer, Michaela, Horré, Katrien, De Strooper, Bart, Saftig, Paul

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Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase von Tolia, Alexandra, Horré, Katrien, De Strooper, Bart

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Nuclear import of the DSCAM‐cytoplasmic domain drives signaling capable of inhibiting synapse formation von Sachse, Sonja M, Lievens, Sam, Ribeiro, Luís F, Dascenco, Dan, Masschaele, Delphine, Horré, Katrien, Misbaer, Anke, Vanderroost, Nele, De Smet, Anne Sophie, Salta, Evgenia, Erfurth, Maria‐Luise, Kise, Yoshiaki, Nebel, Siegfried, Van Delm, Wouter, Plaisance, Stéphane, Tavernier, Jan, De Strooper, Bart, De Wit, Joris, Schmucker, Dietmar

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The dynamic conformational landscape of gamma-secretase von Elad, Nadav, De Strooper, Bart, Lismont, Sam, Hagen, Wim, Veugelen, Sarah, Arimon, Muriel, Horré, Katrien, Berezovska, Oksana, Sachse, Carsten, Chávez-Gutiérrez, Lucía

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Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions von Szaruga, Maria, Munteanu, Bogdan, Lismont, Sam, Veugelen, Sarah, Horré, Katrien, Mercken, Marc, Saido, Takaomi C., Ryan, Natalie S., De Vos, Tatjana, Savvides, Savvas N., Gallardo, Rodrigo, Schymkowitz, Joost, Rousseau, Frederic, Fox, Nick C., Hopf, Carsten, De Strooper, Bart, Chávez-Gutiérrez, Lucía

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γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease von Serneels, Lutgarde, Van Biervliet, Jérôme, Craessaerts, Katleen, Dejaegere, Tim, Horré, Katrien, Van Houtvin, Tine, Esselmann, Hermann, Paul, Sabine, Schäfer, Martin K, Berezovska, Oksana, Hyman, Bradley T, Sprangers, Ben, Sciot, Raf, Moons, Lieve, Jucker, Mathias, Yang, Zhixiang, May, Patrick C, Karran, Eric, Wiltfang, Jens, D'Hooge, Rudi, De Strooper, Bart

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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression von Hébert, Sébastien S, Horré, Katrien, Nicolaï, Laura, Papadopoulou, Aikaterini S, Mandemakers, Wim, Silahtaroglu, Asli N, Kauppinen, Sakari, Delacourte, André, De Strooper, Bart

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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression von Hébert, Sébastien S, Horré, Katrien, Nicolaï, Laura, Bergmans, Bruno, Papadopoulou, Aikaterini S, Delacourte, André, De Strooper, Bart

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Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore von Nelson, Omar, Supnet, Charlene, Tolia, Alexandra, Horré, Katrien, De Strooper, Bart, Bezprozvanny, Ilya

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Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments von Guix, Francesc X, Sannerud, Ragna, Berditchevski, Fedor, Arranz, Amaia M, Horré, Katrien, Snellinx, An, Thathiah, Amantha, Saido, Takaomi, Saito, Takashi, Rajesh, Sundaresan, Overduin, Michael, Kumar-Singh, Samir, Radaelli, Enrico, Corthout, Nikky, Colombelli, Julien, Tosi, Sébastien, Munck, Sebastian, Salas, Isabel H, Annaert, Wim, De Strooper, Bart

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Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model von Rice, Heather, Marcassa, Gabriele, Chrysidou, Iordana, Horre, Katrien, Young-Pearse, Tracy L., Mueller, Ulrike C., Saito, Takashi, Saido, Takaomi C., Vassar, Robert, de Wit, Joris, De Strooper, Bart

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Differential Contribution of the Three Aph1 Genes to γ-Secretase Activity in vivo von Serneels, Lutgarde, Degaegere, Tim, Craessaerts, Katleen, Horré, Katrien, Jorissen, Ellen, Tousseyn, Thomas, Hébert, Sébastien, Coolen, Marcel, Martens, Gerard, Zwijsen, An, Annaert, Wim, Hartmann, Dieter, De Strooper, Bart, Simons, Kai

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PLD3 gene and processing of APP von Fazzari, Pietro, Horre, Katrien, Arranz, Amaia M., Frigerio, Carlo Sala, Saito, Takashi, Saido, Takaomi C., De Strooper, Bart

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