Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers von Ruggeri, Francesco Simone, Habchi, Johnny, Chia, Sean, Horne, Robert I., Vendruscolo, Michele, Knowles, Tuomas P. J.

Volltext

A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation von Kamal, Muntasir, Knox, Jessica, Horne, Robert I., Tiwari, Om Shanker, Burns, Andrew R., Han, Duhyun, Levy, Davide, Laor Bar-Yosef, Dana, Gazit, Ehud, Vendruscolo, Michele, Roy, Peter J.

Volltext

Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation von Staats, Roxine, Brotzakis, Z. Faidon, Chia, Sean, Horne, Robert I., Vendruscolo, Michele

Volltext

Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors von Chandra, Raghav, Horne, Robert I., Vendruscolo, Michele

Volltext

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter von Staats, Roxine, Michaels, Thomas C. T., Flagmeier, Patrick, Chia, Sean, Horne, Robert I., Habchi, Johnny, Linse, Sara, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele

Volltext

Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling von Naugle, Jennifer E, Olson, Erik R, Zhang, Xiaojin, Mase, Sharon E, Pilati, Charles F, Maron, Michael B, Folkesson, Hans G, Horne, Walter I, Doane, Kathleen J, Meszaros, J. Gary

Volltext

53‐2: Invited Paper: Flexible LCDs Enabled by OTFT von Harding, M. James, Horne, I. P., Yaglioglu, B.

Volltext

The effects of hypothyroidism on the proximal femoral physis in miniature swine von Tank, Jason C., Weiner, Dennis S., Jacquet, Robin, Childs, Dylan, Ritzman, Todd F., Horne, Walter I., Steiner, Richard, Morscher, Melanie A., Landis, William J.

Volltext

ENZYMATIC BIOREMEDIATION: FROM ENZYME DISCOVERY TO APPLICATIONS von Sutherland, TD, Horne, I, Weir, KM, Coppin, CW, Williams, MR, Selleck, M, Russell, RJ, Oakeshott, JG

Volltext

A Study in Vivo of the Effects of a Static Compressive Load on the Proximal Tibial Physis in Rabbits von Bries, Andrew D, Weiner, Dennis S, Jacquet, Robin, Adamczyk, Mark J, Morscher, Melanie A, Lowder, Elizabeth, Askew, Michael J, Steiner, Richard P, Horne, Walter I, Landis, William J

Volltext

Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution von Yang, H., Carr, P.D., McLoughlin, S.Yu, Liu, J.W., Horne, I., Qiu, X., Jeffries, C.M.J., Russell, R.J., Oakeshott, J.G., Ollis, D.L.

Volltext

The p53 DNA damage response and Fanconi anemia DNA repair pathway protect against acetaldehyde-induced replication stress in esophageal keratinocytes von Peake, Jasmine D, Horne, Kalisse I, Noguchi, Chiaki, Gilligan, John P, Noguchi, Eishi

Volltext

Isolation and functional characterization of two independently-evolved fatty acid Δ12-desaturase genes from insects von Zhou, X.-R., Horne, I., Damcevski, K., Haritos, V., Green, A., Singh, S.

Volltext

Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α‑Synuclein Secondary Nucleation von Horne, Robert I., Murtada, Mhd Hussein, Huo, Donghui, Brotzakis, Z. Faidon, Gregory, Rebecca C., Possenti, Andrea, Chia, Sean, Vendruscolo, Michele

Volltext

Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity von Horne, Robert I., Wilson-Godber, Jared, González Díaz, Alicia, Brotzakis, Z. Faidon, Seal, Srijit, Gregory, Rebecca C., Possenti, Andrea, Chia, Sean, Vendruscolo, Michele

Volltext

Direct comparison of fluorescence- and bioluminescence-based resonance energy transfer methods for real-time monitoring of thrombin-catalysed proteolytic cleavage von Dacres, H., Dumancic, M.M., Horne, I., Trowell, S.C.

Volltext

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α‑Synuclein Aggregates von Chia, Sean, Faidon Brotzakis, Z., Horne, Robert I., Possenti, Andrea, Mannini, Benedetta, Cataldi, Rodrigo, Nowinska, Magdalena, Staats, Roxine, Linse, Sara, Knowles, Tuomas P. J., Habchi, Johnny, Vendruscolo, Michele

Volltext

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores von Sandler, Sarah E, Horne, Robert I, Rocchetti, Sara, Novak, Robert, Hsu, Nai-Shu, Castellana Cruz, Marta, Faidon Brotzakis, Z, Gregory, Rebecca C, Chia, Sean, Bernardes, Gonçalo J L, Keyser, Ulrich F, Vendruscolo, Michele

Volltext

Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning von Horne, Robert I., Andrzejewska, Ewa A., Alam, Parvez, Brotzakis, Z. Faidon, Srivastava, Ankit, Aubert, Alice, Nowinska, Magdalena, Gregory, Rebecca C., Staats, Roxine, Possenti, Andrea, Chia, Sean, Sormanni, Pietro, Ghetti, Bernardino, Caughey, Byron, Knowles, Tuomas P. J., Vendruscolo, Michele

Volltext

The influence of experimental manipulations on chewing speed during in vivo laboratory research in tufted capuchins (Cebus apella) von Thompson, C.L., Donley, E.M., Stimpson, C.D., Horne, W.I., Vinyard, C.J.

Volltext