An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software von Shah, Pranav, Kerns, Edward, Nguyen, Dac-Trung, Obach, R Scott, Wang, Amy Q, Zakharov, Alexey, McKew, John, Simeonov, Anton, Hop, Cornelis E C A, Xu, Xin

Volltext

A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834 von Sodhi, Jasleen K, Wong, Susan, Kirkpatrick, Donald S, Liu, Lichuan, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A, Barr, John T, Jones, Jeffrey P, Halladay, Jason S

Volltext

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma von Mao, Jialin, Tay, Suzanne, Khojasteh, Cyrus S., Chen, Yuan, Hop, Cornelis E. C. A., Kenny, Jane R.

Volltext

Opportunities and challenges using artificial intelligence in ADME/Tox von Bhhatarai, Barun, Walters, W. Patrick, Hop, Cornelis E. C. A., Lanza, Guido, Ekins, Sean

Volltext

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor von LICHUAN LIU, HALLADAY, Jason S, KUEBLER, Peter, DAVIS, John C, CHARLENE LIAO, X, LUBACH, Joseph W, DEESE, Alan, SOWELL, C. Gregory, CURRIE, Kevin S, YOUNG, Wendy B, KHOJASTEH, S. Cyrus, HOP, Cornelis E. C. A, SHIN, Young, WONG, Harvey, WONG, Susan, CORAGGIO, Melis, LA, Hank, BAUMGARDNER, Matthew, LE, Hoa, GOPAUL, Sashi, BOGGS, Jason

Volltext

Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small i... von Li, Albert P., Ho, Ming‐Chih D., Alam, Novera, Mitchell, Walter, Wong, Susan, Yan, Zhengyin, Kenny, Jane R., E. C. A. Hop, Cornelis

Volltext

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass sp... von Prasad, Bhagwat, Evers, Raymond, Gupta, Anshul, Hop, Cornelis E C A, Salphati, Laurent, Shukla, Suneet, Ambudkar, Suresh V, Unadkat, Jashvant D

Volltext

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study von Prasad, Bhagwat, Bhatt, Deepak Kumar, Johnson, Katherine, Chapa, Revathi, Chu, Xiaoyan, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Hop, Cornelis E.C.A., Mathias, Anita, Lai, Yurong, Liao, Mingxiang, Humphreys, William G., Kumer, Sean C., Unadkat, Jashvant D.

Volltext

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics von Billington, Sarah, Salphati, Laurent, Hop, Cornelis E. C. A., Chu, Xiaoyan, Evers, Raymond, Burdette, Doug, Rowbottom, Christopher, Lai, Yurong, Xiao, Guangqing, Humphreys, W. Griffith, Nguyen, Tot Bui, Prasad, Bhagwat, Unadkat, Jashvant D.

Volltext

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates von Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S, Pillow, Thomas H, Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D, Erickson, Hans K, Hop, Cornelis E. C. A, Khojasteh, S. Cyrus

Volltext

Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs von Zhang, Donglu, Ma, Bin, Dragovich, Peter S., Ma, Li, Chen, Shu, Chen, Eugene C., Ye, Xiaofen, Liu, Joyce, Pizzano, Jennifer, Bortolon, Elizabeth, Chan, Emily, Zhang, Xing, Chen, Yi-Chen, Levy, Elizabeth S., Yauch, Robert L., Khojasteh, S. Cyrus, Hop, Cornelis E. C. A.

Volltext

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics von Wang, Li, Collins, Carol, Kelly, Edward J, Chu, Xiaoyan, Ray, Adrian S, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Lai, Yurong, Liao, Mingxiang, Mathias, Anita, Evers, Raymond, Humphreys, William, Hop, Cornelis E C A, Kumer, Sean C, Unadkat, Jashvant D

Volltext

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound von Mao, Jialin, Fan, Peter, Wong, Susan, Wang, Jianshuang, Ismaili, Moulay Hicham Alaoui, Dean, Brian, Hop, Cornelis E. C. A., Wright, Matthew, Chen, Yuan

Volltext

Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone von Chen, Yuan, Mao, Jialin, Hop, Cornelis E.C.A.

Volltext

High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening von Ding, Xiao, Ghobarah, Hesham, Zhang, Xiaolin, Jaochico, Allan, Liu, Xingrong, Deshmukh, Gauri, Liederer, Bianca M., Hop, Cornelis E. C. A., Dean, Brian

Volltext

A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted... von Kumar, Vineet, Salphati, Laurent, Hop, Cornelis E C A, Xiao, Guangqing, Lai, Yurong, Mathias, Anita, Chu, Xiaoyan, Humphreys, W Griffith, Liao, Mingxiang, Heyward, Scott, Unadkat, Jashvant D

Volltext

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry von GRAHAM, Richard A, LUM, Bert L, MINLI XIE, LOW, Jennifer A, HOP, Cornelis E. C. A, MORRISON, Glenn, CHANG, Ilsung, JORGA, Karin, DEAN, Brian, SHIN, Young G, QIN YUE, MULDER, Teresa, MALHI, Vikram

Volltext

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response von WONG, Harvey, CHOO, Edna F, GOULD, Stephen E, ALICKE, Bruno, XIAO DING, LA, Hank, MCNAMARA, Erin, THEIL, Frank-Peter, TIBBITTS, Jay, FRIEDMAN, Lori S, HOP, Cornelis E. C. A

Volltext

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry von Ding, X., Chou, B., Graham, R.A., Cheeti, S., Percey, S., Matassa, L.C., Reuschel, S.A., Meng, M., Liu, S., Voelker, T., Lum, B.L., Rudewicz, P.J., Hop, C.E.C.A.

Volltext

Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Rela... von Kumar, Vineet, Prasad, Bhagwat, Patilea, Gabriela, Gupta, Anshul, Salphati, Laurent, Evers, Raymond, Hop, Cornelis E. C. A, Unadkat, Jashvant D.

Volltext