Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs von Chen, S, Zambetti, N A, Bindels, E M J, Kenswill, K, Mylona, A M, Adisty, N M, Hoogenboezem, R M, Sanders, M A, Cremers, E M P, Westers, T M, Jansen, J H, van de Loosdrecht, A A, Raaijmakers, M H G P

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Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes von Zambetti, Noemi A, Bindels, Eric M J, Van Strien, Paulina M H, Valkhof, Marijke G, Adisty, Maria N, Hoogenboezem, Remco M, Sanders, Mathijs A, Rommens, Johanna M, Touw, Ivo P, Raaijmakers, Marc H G P

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MicroRNA-155 induces AML in combination with the loss of C/EBPA in mice von Alemdehy, M F, de Looper, H W J, Kavelaars, F G, Sanders, M A, Hoogenboezem, R, Löwenberg, B, Valk, P J M, Touw, I P, Erkeland, S J

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B05 PLASMA CELL LEUKEMIA‐LIKE STATUS HAS INDEPENDENT PROGNOSTIC VALUE IN THE CONTEXT OF THE SECOND REVISION OF THE INTERNATIONAL STAGING SYSTEM von Hofste op Bruinink, D., Kuiper, R., Duin, M., Cupedo, T., Velden, V., Hoogenboezem, R., Holt, B., Beverloo, B., Valent, E., Vermeulen, M., D'Agostino, M., Gay, F., Broijl, A., Avet‐Loiseau, H., Munshi, N., Musto, P., Moreau, P., Zweegman, S., Donk, N., Sonneveld, P.

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Lack of splice factor and cohesin complex mutations in pediatric myelodysplastic syndrome von Obenauer, Julia C, Kavelaars, François G, Sanders, Mathijs A, Hoogenboezem, Remco M, de Vries, Andrica C H, van Strien, Paulina M H, de Haas, Valerie, Locatelli, Franco, Hasle, Henrik, Valk, Peter J M, Touw, Ivo P, van den Heuvel-Eibrink, Marry M

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Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations von Abbas, Saman, Sanders, Mathijs A, Zeilemaker, Annelieke, Geertsma-Kleinekoort, Wendy M C, Koenders, Jasper E, Kavelaars, Francois G, Abbas, Zabiollah G, Mahamoud, Souad, Chu, Isabel W T, Hoogenboezem, Remco, Peeters, Justine K, van Drunen, Ellen, van Galen, Janneke, Beverloo, H Berna, Löwenberg, Bob, Valk, Peter J M

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Introduction of an embolus detection system based on analysis of the transcranial Doppler audio-signal von Keunen, R. W. M., Hoogenboezem, R., Wijnands, R., Van den Hengel, A. C. M., Ackerstaff, R. G. A.

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P110 TIGIT expression identifies circulating CD38+ effector T cells with immune regulatory properties whose frequencies at diagnosis predict disease course of paediatric IBD patien... von Joosse, M, Joosse, M, Menckeberg, C, de Ruiter, L F, Raatgeep, H, van Berkel, L A, Simons-Oosterhuis, Y, Hendriks, R W, Hoogenboezem, R M, Cupedo, T, de Ridder, L, Escher, J, Veenbergen, S, Samsom, J N

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S887 DISSECTING THE ROLE OF CXCL4 IN PRIMARY MYELOFIBROSIS von Gleitz, H., Dugourd, A., Leimkühler, N., Snoeren, I., Fuchs, S., Banjanin, B., Pritchard, J., Hoogenboezem, R., Bindels, E., Saez‐Rodriguez, J., Kramann, R., Schneider, R.

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S862 THE ROLE OF GATA2 IN HSC GENERATION THROUGH ENDOTHELIAL‐TO‐HEMATOPOIETIC TRANSITION von Koyunlar, C., Gioacchino, E., Hoogenboezem, R., Looper, H., Bosch, D., Klavert, J., Havermans, M., Strien, P., Bindels, E., Delwel, R., Dzierzak, E., Touw, I., Pater, E.

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PF346 ZEBRAFISH AS A NOVEL MODEL TO STUDY GATA2 HAPLOINSUFFICIENCY SYNDROMES von Gioacchino, E., Koyunlar, C., looper, H., Peulen, J., Bosch, D., hoogenboezem, R., strien, P., Bindels, E., Touw, I., Pater, E.

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Cooperativity Of RUNX1 and CSF3R Mutations In The Development Of Leukemia In Severe Congenital Neutropenia: A Unique Pathway In Myeloid Leukemogenesis von Skokowa, Julia, Steinemann, Doris, Katsman-Kuipers, Jenny, Zeidler, Cornelia, Klimenkova, Olga, Klimiankou, Maksim, Uenalan, Murat, Kandabarau, Siarhei, Makaryan, Vahagn, Beekman, Renee, Stocking, Carol, Obenauer, J, Schnittger, Susanne, Kohlmann, Alexander, Valkhof, M, Hoogenboezem, R, Göhring, Gudrun, Reinhardt, Dirk, Schlegelberger, Brigitte, Stanulla, Martin, Vandenberghe, Peter, Donadieu, Jean, Zwaan, Michel, Touw, Ivo P., van den Heuvel-Eibrink, Marry M., Dale, David C., Welte, Karl

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Seismic buffer recognition using wavelet-based features and neural classification von Hoffman, Alwyn, Hoogenboezem, Riaan, Van Der Merwe, Theo, Tollig, Tonie

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Decoding myofibroblast origins in human kidney fibrosis von Kuppe, Christoph, Ibrahim, Mahmoud M., Kranz, Jennifer, Zhang, Xiaoting, Ziegler, Susanne, Perales-Patón, Javier, Jansen, Jitske, Reimer, Katharina C., Smith, James R., Dobie, Ross, Wilson-Kanamori, John R., Halder, Maurice, Xu, Yaoxian, Kabgani, Nazanin, Kaesler, Nadine, Klaus, Martin, Gernhold, Lukas, Puelles, Victor G., Huber, Tobias B., Boor, Peter, Menzel, Sylvia, Hoogenboezem, Remco M., Bindels, Eric M. J., Steffens, Joachim, Floege, Jürgen, Schneider, Rebekka K., Saez-Rodriguez, Julio, Henderson, Neil C., Kramann, Rafael

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Hemolysis in the spleen drives erythrocyte turnover von Klei, T.R.L, Dalimot, J., Nota, B., Veldthuis, M., Mul, F.P.J, Rademakers, T., Hoogenboezem, M., Nagelkerke, S.Q., van IJcken, W.F.J, Oole, E., Svendsen, P., Moestrup, S.K., van Alphen, F.P.J, Meijer, A.B., Kuijpers, T.W., van Zwieten, R., van Bruggen, R.

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Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering von Wachs, RA, Hoogenboezem, EN, Huda, HI, Xin, S, Porvasnik, SL, Schmidt, CE

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Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy von Hoogenboezem, Ella N., Patel, Shrusti S., Lo, Justin H., Cavnar, Ashley B., Babb, Lauren M., Francini, Nora, Gbur, Eva F., Patil, Prarthana, Colazo, Juan M., Michell, Danielle L., Sanchez, Violeta M., McCune, Joshua T., Ma, Jinqi, DeJulius, Carlisle R., Lee, Linus H., Rosch, Jonah C., Allen, Ryan M., Stokes, Larry D., Hill, Jordan L., Vickers, Kasey C., Cook, Rebecca S., Duvall, Craig L.

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Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing von Patel, Shrusti S., Hoogenboezem, Ella N., Yu, Fang, DeJulius, Carlisle R., Fletcher, R. Brock, Sorets, Alex G., Cherry, Fiona K., Lo, Justin H., Bezold, Mariah G., Francini, Nora, d’Arcy, Richard, Brasuell, Jordan E., Cook, Rebecca S., Duvall, Craig L.

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Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia von Smeenk, Leonie, Ottema, Sophie, Mulet-Lazaro, Roger, Ebert, Anja, Havermans, Marije, Varea, Andrea Arricibita, Fellner, Michaela, Pastoors, Dorien, van Herk, Stanley, Erpelinck-Verschueren, Claudia, Grob, Tim, Hoogenboezem, Remco M, Kavelaars, François G, Matson, Daniel R, Bresnick, Emery H, Bindels, Eric M, Kentsis, Alex, Zuber, Johannes, Delwel, Ruud

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Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling von de Groot, R C A, Zhu, H, Hoogenboezem, T, de Bruijn, A C J M, Eenjes, E, 't Jong, A E J, Belo, A I, Estevão, S C, Bajramovic, J J, Rottier, R J, Kool, M, van Rossum, A M C, Unger, W W J

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