Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR von Hajduk, P. J, Sheppard, G, Nettesheim, D. G, Olejniczak, E. T, Shuker, S. B, Meadows, R. P, Steinman, D. H, Carrera, G. M, Marcotte, P. A, Severin, J, Walter, K, Smith, H, Gubbins, E, Simmer, R, Holzman, T. F, Morgan, D. W, Davidsen, S. K, Summers, J. B, Fesik, S. W

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Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths von Snyder, S.W., Ladror, U.S., Wade, W.S., Wang, G.T., Barrett, L.W., Matayoshi, E.D., Huffaker, H.J., Krafft, G.A., Holzman, T.F.

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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ 1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress von Oda, Tomiichiro, Wals, Pat, Osterburg, Heinz H., Johnson, Steven A., Pasinetti, Giulio M., Morgan, Todd E., Rozovsky, Irina, Stine, W.Blaine, Snyder, Seth W., Holzman, Thomas F., Krafft, Grant A., Finch, Caleb E.

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Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D von LADROR, U. S, SNYDER, S. W, WANG, G. T, HOLZMAN, T. F, KRAFFT, G. A

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NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein von Hajduk, Philip J, Dinges, Jürgen, Miknis, Gregory F, Merlock, Megan, Middleton, Tim, Kempf, Dale J, Egan, David A, Walter, Karl A, Robins, Terry S, Shuker, Suzy B, Holzman, Thomas F, Fesik, Stephen W

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Variants in Apaf-1 segregating with major depression promote apoptosome function von Harlan, J, Chen, Y, Gubbins, E, Mueller, R, Roch, J-M, Walter, K, Lake, M, Olsen, T, Metzger, P, Dorwin, S, Ladror, U, Egan, D A, Severin, J, Johnson, R W, Holzman, T F, Voelp, K, Davenport, C, Beck, A, Potter, J, Gopalakrishnan, M, Hahn, A, Spear, B B, Halbert, D N, Sullivan, J P, Abkevich, V, Neff, C D, Skolnick, M H, Shattuck, D, Katz, D A

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Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments von Hajduk, Philip J, Gomtsyan, Arthur, Didomenico, Stanley, Cowart, Marlon, Bayburt, Erol K, Solomon, Larry, Severin, Jean, Smith, Richard, Walter, Karl, Holzman, Thomas F, Stewart, Andrew, McGaraughty, Steve, Jarvis, Michael F, Kowaluk, Elizabeth A, Fesik, Stephen W

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NMR studies of [U-13C] cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding von Fesik, Stephen W, Gampe, R. T, Eaton, H. L, Gemmecker, G, Olejniczak, E. T, Neri, P, Holzman, T. F, Egan, D. A, Edalji, R

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Stromelysin Inhibitors Designed from Weakly Bound Fragments:  Effects of Linking and Cooperativity von Olejniczak, E. T, Hajduk, P. J, Marcotte, P. A, Nettesheim, D. G, Meadows, R. P, Edalji, R, Holzman, T. F, Fesik, Stephen W

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Equilibrium denaturation of recombinant human FK binding protein in urea von Egan, D. A, Logan, T. M, Liang, H, Matayoshi, E, Fesik, S. W, Holzman, T. F

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Isotope-Edited NMR of Cyclosporin A Bound to Cyclophilin: Evidence for a Trans 9,10 Amide Bond von Fesik, S. W., Gampe, R. T., Holzman, T. F., Egan, D. A., Edalji, R., Luly, J. R., Simmer, R., Helfrich, R., Kishore, V., Rich, D. H.

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β/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells von Lambert, M. P., Stevens, G., Sabo, S., Barber, K., Wang, G., Wade, W., Krafft, G., Snyder, S., Holzman, T. F., Klein, W. L.

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Complement C1q Does Not Bind Monomeric β-Amyloid von Snyder, S.W., Wang, G.T., Barrett, L., Ladror, U.S., Casuto, D., Lee, C.M., Krafft, G.A., Holzman, R.B., Holzman, T.F.

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A Continuous Fluorescence Assay of Renin Activity von Wang, G.T., Chung, C.C., Holzman, T.F., Krafft, G.A.

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Substrate requirements for ErmC' methyltransferase activity von Zhong, P, Pratt, S D, Edalji, R P, Walter, K A, Holzman, T F, Shivakumar, A G, Katz, L

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Driving affinity selection by centrifugal force von Harlan, J E, Egan, D A, Ladror, U S, Snyder, S, Tang, M I, Buko, A, Holzman, T F

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Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin von HOLZMAN, T. F, EGAN, D. A, EDALJI, R, SIMMER, R. L, HELFRICH, R, TAYLOR, A, BURRES, N. S

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Solution structure of the cyclosporin A/cyclophilin complex by NMR von Thériault, Yves, Logan, Timothy M, Meadows, Robert, Yu, Liping, Olejniczak, Edward T, Holzman, Thomas F, Simmer, Robert L, Fesik, Stephen W

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Inhibitor stabilization of human immunodeficiency virus type-2 proteinase dimer formation von HOLZMAN, T. F, KOHLBRENNER, W. E, WEIGL, D, RITTENHOUSE, J, KEMPF, D, ERICKSON, J

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NMR studies of an FK-506 analog [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding von Petros, A. M, Gampe, R. T, Gemmecker, G, Neri, P, Holzman, T. F, Edalji, R, Hochlowski, J, Jackson, M, McAlpine, J

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