Fragment-to-Lead Medicinal Chemistry Publications in 2022 von Woodhead, Andrew J., Erlanson, Daniel A., de Esch, Iwan J. P., Holvey, Rhian S., Jahnke, Wolfgang, Pathuri, Puja

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C-H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD) von Chessari, Gianni, Grainger, Rachel, Holvey, Rhian S, Ludlow, R. Frederick, Mortenson, Paul N, Rees, David C

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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2) von Day, James E. H., Berdini, Valerio, Castro, Joan, Chessari, Gianni, Davies, Thomas G., Day, Philip J., St. Denis, Jeffrey D., Fujiwara, Hideto, Fukaya, Satoshi, Hamlett, Christopher C. F., Hearn, Keisha, Hiscock, Steven D., Holvey, Rhian S., Ito, Satoru, Kandola, Navrohit, Kodama, Yasuo, Liebeschuetz, John W., Martins, Vanessa, Matsuo, Kenichi, Mortenson, Paul N., Muench, Sandra, Nakatsuru, Yoko, Ochiiwa, Hiroaki, Palmer, Nicholas, Peakman, Torren, Price, Amanda, Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Shibata, Yoshihiro, Smyth, Tomoko, Twigg, David G., Wallis, Nicola G., Williams, Glyn, Wilsher, Nicola E., Woodhead, Andrew, Shimamura, Tadashi, Johnson, Christopher N.

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Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design von Holvey, Rhian S., Valkov, Eugene, Neal, David, Stewart, Murray, Abell, Chris

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Selective Targeting of the TPX2 Site of Importin-[alpha] Using Fragment-Based Ligand Design von Holvey, Rhian S, Valkov, Eugene, Neal, David, Stewart, Murray, Abell, Chris

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction von Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan

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A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor von Malet-Sanz, Laia, Madrzak, Julia, Holvey, Rhian S., Underwood, Toby

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Abstract 1039: Fragment-based drug discovery to identify small molecule allosteric inhibitors of SHP2 von Day, Philip J., Berdini, Valerio, Castro, Juan, Chessari, Gianni, Davies, Thomas G., Day, James E., Fukaya, Satoshi, Hamlett, Chris, Hearn, Keisha, Hiscock, Steve, Holvey, Rhian, Ito, Satoru, Kodama, Yasuo, Matsuo, Kenichi, Nakatsuru, Yoko, Palmer, Nick, Price, Amanda, Shimamura, Tadashi, Denis, Jeffrey D.St, Wallis, Nicola G., Williams, Glyn, Johnson, Christopher N.

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A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION von ASAKURA, HIROKI, HOLVEY, RHIAN SARA, SAGARA, TAKESHI, NAKAMURA, MASAYUKI, KAWAI, YUICHI, UNO, TAKAO, KOBAYAKAWA, YU, SHIBATA, KAZUAKI

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A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION von KAWAI, Yuichi, ASAKURA, Hiroki, SAGARA, Takeshi, HOLVEY, Rhian, Sara, SHIBATA, Kazuaki, UNO, Takao, KOBAYAKAWA, Yu, NAKAMURA, Masayuki

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A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION von KAWAI, Yuichi, ASAKURA, Hiroki, SAGARA, Takeshi, HOLVEY, Rhian, SHIBATA, Kazuaki, UNO, Takao, KOBAYAKAWA, Yu, NAKAMURA, Masayuki

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Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them von Gaunt, Matthew James, Shanmugham, Meenakshi Sundaram, Priede, Jonas Calleja, Dumas, Aaron Michael, Dixon, Darren James, Nash, David John, Parry-Jones, David, Osborne, James Daniel, Cons, Benjamin David, Holvey, Rhian Sara, Parra, Guillaume François, Richards, Nicholas Paul, Bishop, Brian Christopher, Hirst, Kim Louise, St. Denis, Jeffrey David, Lemasson, Isabelle Anne, Howard, Steven

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Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity von Peach, Joanne, Noble, Martin Edward Mäntylä, Mitchell, Dale Robert, Cano, Celine Florence, Miller, Duncan Charles, Osborne, James Daniel, Whittaker, Benjamin Paul, Chessari, Gianni, Cons, Benjamin David, Holvey, Rhian Sara, Tamanini, Emiliano, Lewis, Arwel, Buck, Ildiko Maria, Griffin, Roger John, Watson, David Wyn, Hirst, Kim Louise, Rees, David Charles, St. Denis, Jeffrey David, Golding, Bernard Thomas, Hardcastle, Ian Robert, Johnson, Christopher Norbert, Howard, Steven

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A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION von NAKAMURA Masayuki, SAGARA Takeshi, KAWAI Yuichi, SHIBATA Kazuaki, KOBAYAKAWA Yu, HOLVEY, Rhian Sara, UNO Takao, ASAKURA Hiroki

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PHARMACEUTICAL COMPOUNDS von ST DENIS, Jeffrey David, LIEBESCHUETZ, John Walter, JOHNSON, Christopher Norbert, DAY, James Edward Harvey, FUJIWARA, Hideto, HISCOCK, Steven Douglas, HOLVEY, Rhian Sara, BUCK, Ildiko Maria, WOODHEAD, Andrew James, HAMLETT, Christopher Charles Frederick, HOWARD, Steven, TWIGG, David Geoffrey, CHESSARI, Gianni, PALMER, Nicholas John

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Pharmaceutical compounds von Twigg, David Geoffrey, Hiscock, Steven Douglas, Hamlett, Christopher Charles Frederick, Chessari, Gianni, Palmer, Nicholas John, Day, James Edward Harvey, Holvey, Rhian Sara, Buck, Ildiko Maria, Liebeschuetz, John Walter, Fujiwara, Hideto, Woodhead, Andrew James, St Denis, Jeffrey David, Johnson, Christopher Norbert, Howard, Steven

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Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity von MILLER, Duncan Charles, WATSON, David Wyn, MITCHELL, Dale Robert, JOHNSON, Christopher Norbert, PEACH, Joanne, ST. DENIS, Jeffrey David, CANO, Celine Florence, WHITTAKER, Benjamin Paul, HOLVEY, Rhian Sara, CULLY, Sarah, LEWIS, Arwel, CONS, Benjamin David, BUCK, Ildiko Maria, TAMANINI, Emiliano, HARDCASTLE, Ian Robert, OSBORNE, James Daniel, HOWARD, Steven, GOLDING, Bernard Thomas, HIRST, Kim Louise, REES, David Charles, NOBLE, Martin Edward Mäntylä, CHESSARI, Gianni, GRIFFIN, Roger John

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Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design von Holvey, Rhian S, Valkov, Eugene, Neal, David, Stewart, Murray, Abell, Chris

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ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY von ST. DENIS Jeffrey David, GOLDING Bernard Thomas, REES David Charles, CULLY Sarah, WHITTAKER Benjamin Paul, MITCHELL Dale Robert, TAMANINI Emiliano, CONS Benjamin David, BUCK Ildiko Maria, JOHNSON Christopher Norbert, PEACH Joanne, CHESSARI Gianni, NOBLE Martin Edward Mantyla, OSBORNE James Daniel, CANO Celine Florence, LEWIS Arwel, WATSON David Wyn, HOLVEY Rhian Sara, HARDCASTLE Ian Robert, GRIFFIN Roger John, HOWARD Steven, MILLER Duncan Charles, HIRST Kim Louise

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INTERMEDIATES OF ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY von Peach, Joanne, Noble, Martin Edward Mäntylä, Mitchell, Dale Robert, Cano, Celine Florence, Miller, Duncan Charles, Osborne, James Daniel, Whittaker, Benjamin Paul, Chessari, Gianni, Cons, Benjamin David, Holvey, Rhian Sara, Cully, Sarah, Tamanini, Emiliano, Buck, Ildiko Maria, Griffin, Roger John, Watson, David Wyn, Lewis, Arwell, Hirst, Kim Louise, St. Denis, Jeffrey David, Golding, Bernard Thomas, Rees, David Charles, Hardcastle, Ian Robert, Johnson, Christopher Norbert, Howard, Steven

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