A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation―Driven Colorectal Tumor Growth von LAU, Ted, CHAN, Emily, MACHON, Ondrej, KORINEK, Vladimir, CHOO, Edna, DIAZ, Dolores, MERCHANT, Mark, POLAKIS, Paul, HOLSWORTH, Daniel D, KRAUSS, Stefan, COSTA, Mike, CALLOW, Marinella, WAALER, Jo, BOGGS, Jason, BLAKE, Robert A, MAGNUSON, Steven, SAMBRONE, Amy, SCHUTTEN, Melissa, FIRESTEIN, Ron

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Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor von Voronkov, Andrew, Holsworth, Daniel D, Waaler, Jo, Wilson, Steven R, Ekblad, Bie, Perdreau-Dahl, Harmonie, Dinh, Huyen, Drewes, Gerard, Hopf, Carsten, Morth, Jens P, Krauss, Stefan

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A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model von Strand, Martin F, Wilson, Steven R, Dembinski, Jennifer L, Holsworth, Daniel D, Khvat, Alexander, Okun, Ilya, Petersen, Dirk, Krauss, Stefan

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Binding thermodynamics of substituted diaminopyrimidine renin inhibitors von Sarver, Ronald W., Peevers, Jeanette, Cody, Wayne L., Ciske, Fred L., Dyer, Jim, Emerson, S. Donald, Hagadorn, Jeanne C., Holsworth, Daniel D., Jalaie, Mehran, Kaufman, Michael, Mastronardi, Michelle, McConnell, Patrick, Powell, Noel A., Quin, John, Van Huis, Chad A., Zhang, Erli, Mochalkin, Igor

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The flexible alignment of molecular structures using simulated annealing with weighted Lagrangian multipliers von Raymond, John W., Holsworth, Daniel D., Jalaie, Mehran

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Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors von Powell, Noel A., Ciske, Fred L., Cai, Cuiman, Holsworth, Daniel D., Mennen, Ken, Van Huis, Chad A., Jalaie, Mehran, Day, Jacqueline, Mastronardi, Michelle, McConnell, Pat, Mochalkin, Igor, Zhang, Erli, Ryan, Michael J., Bryant, John, Collard, Wendy, Ferreira, Suzie, Gu, Chungang, Collins, Roxane, Edmunds, Jeremy J.

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Steric Hindrance as a Basis for Structure-Based Design of Selective Inhibitors of Protein-Tyrosine Phosphatases von Iversen, Lars Fogh, Andersen, Henrik Sune, Møller, Karin Bach, Olsen, Ole Hvilsted, Peters, Günther H, Branner, Sven, Mortensen, Steen B, Hansen, Thomas Kruse, Lau, Jesper, Ge, Yu, Holsworth, Daniel D, Newman, Michael J, Hundahl Møller, Niels Peter

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Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors von Holsworth, Daniel D., Jalaie, Mehran, Belliotti, Thomas, Cai, Cuiman, Collard, Wendy, Ferreira, Suzie, Powell, Noel A., Stier, Michael, Zhang, Erli, McConnell, Pat, Mochalkin, Igor, Ryan, Michael J., Bryant, John, Li, Tingsheng, Kasani, Aparna, Subedi, Rajendra, Maiti, Samarendra N., Edmunds, Jeremy J.

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Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta von Lund, Ida Katrine, Andersen, Henrik Sune, Iversen, Lars Fogh, Olsen, Ole Hvilsted, Møller, Karin Bach, Pedersen, Anja Kallesøe, Ge, Yu, Holsworth, Daniel D, Newman, Michael J, Axe, Frank U, Møller, Niels Peter Hundahl

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Ketopiperazine-based renin inhibitors: Optimization of the “C” ring von Holsworth, Daniel D., Cai, Cuiman, Cheng, Xue-Min, Cody, Wayne L., Downing, Dennis M., Erasga, Noe, Lee, Chitase, Powell, Noel A., Edmunds, Jeremy J., Stier, Michael, Jalaie, Mehran, Zhang, Erli, McConnell, Pat, Ryan, Michael J., Bryant, John, Li, Tingsheng, Kasani, Aparna, Hall, Eric, Subedi, Rajendra, Rahim, Mohammad, Maiti, Samarendra

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The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors von Cody, Wayne L., Holsworth, Daniel D., Powell, Noel A., Jalaie, Mehran, Zhang, Erli, Wang, Wei, Samas, Brian, Bryant, John, Ostroski, Robert, Ryan, Michael J., Edmunds, Jeremy J.

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Discovery of novel non-peptidic ketopiperazine-based renin inhibitors von Holsworth, Daniel D., Powell, Noel A., Downing, Dennis M., Cai, Cuiman, Cody, Wayne L., Ryan, J. Michael, Ostroski, Robert, Jalaie, Mehran, Bryant, John W., Edmunds, Jeremy J.

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Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors von Powell, Noel A., Clay, Emma H., Holsworth, Daniel D., Bryant, John W., Ryan, Michael J., Jalaie, Mehran, Edmunds, Jeremy J.

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Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors von Powell, Noel A., Clay, Emma H., Holsworth, Daniel D., Bryant, John W., Ryan, Michael J., Jalaie, Mehran, Zhang, Erli, Edmunds, Jeremy J.

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Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo Amide−Epoxide Cyclization von Powell, Noel A, Ciske, Fred L, Clay, Emma C, Cody, Wayne L, Downing, Dennis M, Blazecka, Peter G, Holsworth, Daniel D, Edmunds, Jeremy J

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Use of electrospray ionization mass spectrometry to probe antisense peptide interactions von Loo, Joseph A., Holsworth, Daniel D., Root-Bernstein, Robert S.

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A convenient large-scale chiral synthesis of protected 2-substituted 4-oxo-piperidine derivatives von Lau, Jesper F, Kruse Hansen, Thomas, Paul Kilburn, John, Frydenvang, Karla, Holsworth, Daniel D, Ge, Yu, Uyeda, Roy T, Judge, Luke M, Sune Andersen, Henrik

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COMPOSITIONS AND METHODS FOR WOUND TREATMENT von HOLSWORTH, Daniel D

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Compositions and methods for wound treatment von Holsworth, Daniel D

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Augmentation of Aortic Ring Contractions by Angiotensin II Antisense Peptide von Dillon, Patrick F, Root-Bernstein, Robert S, Holsworth, Daniel D

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