Functionalized Polymers-Emerging Versatile Tools for Solution-Phase Chemistry and Automated Parallel Synthesis von Kirschning, Andreas, Monenschein, Holger, Wittenberg, Rüdiger

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Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment o... von Horne, Daniel B, Biswas, Kaustav, Brown, James, Bartberger, Michael D, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R, Lehto, Sonya G, Liu, Qingyian, Ma, Vu V, Monenschein, Holger, Nguyen, Thomas T, Yuan, Chester C, Youngblood, Beth D, Zhang, Maosheng, Zhong, Wenge, Allen, Jennifer R, Chen, Jian Jeffrey, Gavva, Narender R

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Total Synthesis of Apoptolidin:  Construction of Enantiomerically Pure Fragments von Nicolaou, K. C, Fylaktakidou, Konstantina C, Monenschein, Holger, Li, Yiwei, Weyershausen, Bernd, Mitchell, Helen J, Wei, Heng-xu, Guntupalli, Prasuna, Hepworth, David, Sugita, Kazuyuki

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2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics von Zeng, Qingping, Bourbeau, Matthew P., Wohlhieter, G. Erich, Yao, Guomin, Monenschein, Holger, Rider, James T., Lee, Matthew R., Zhang, Shiwen, Lofgren, Julie, Freeman, Daniel, Li, Chun, Tominey, Elizabeth, Huang, Xin, Hoffman, Douglas, Yamane, Harvey, Tasker, Andrew S., Dominguez, Celia, Viswanadhan, Vellarkad N., Hungate, Randall, Zhang, Xiaoling

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Identification of CVN058, a Novel Brain Penetrant, Selective 5-HT3 Receptor Antagonist That Shows Efficacy in Pre-Clinical Cognition Models von Brice, Nicola, Dawson, Lee A., Margolin, David H., Schiffer, Hans H., Monenschein, Holger, Ray, William J., Hitchcock, Stephen, Carlton, Mark

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Application of polymer-supported electrophilic reagents for the 1,2-functionalization of glycals von Kirschning, Andreas, Jesberger, Martin, Monenschein, Holger

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Asymmetric Nucleophilic Acylation of Aldehydes via 1,1-Heterodisubstituted Alkenes von Monenschein, Holger, Dräger, Gerald, Jung, Alexander, Kirschning, Andreas

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First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson’s Disease: Discovery, Pharmacological Validation, and Identification of... von Sun, Huikai, Monenschein, Holger, Schiffer, Hans H, Reichard, Holly A, Kikuchi, Shota, Hopkins, Maria, Macklin, Todd K, Hitchcock, Stephen, Adams, Mark, Green, Jason, Brown, Jason, Murphy, Sean T, Kaushal, Nidhi, Collia, Deanna R, Moore, Steve, Ray, William J, English, Nicole Marion, Carlton, Mark Beresford Lewis, Brice, Nicola L

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S180. THE SELECTIVE GPR139 AGONIST TAK-041 REVERSES ANHEDONIA AND SOCIAL INTERACTION DEFICITS IN RODENT MODELS RELATED TO NEGATIVE SYMPTOMS IN SCHIZOPHRENIA von Schiffer, Hans, Atienza, Josephine, Reichard, Holly, Mulligan, Victoria, Cilia, Jackie, Monenschein, Holger, Collia, Deanna, Ray, Jim, Kilpatrick, Gavin, Brice, Nicola, Carlton, Mark, Hitchcock, Steve, Corbett, Ged, Hodgson, Robert

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Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia von Reichard, Holly A, Schiffer, Hans H, Monenschein, Holger, Atienza, Josephine M, Corbett, Gerard, Skaggs, Alton W, Collia, Deanna R, Ray, William J, Serrats, Jordi, Bliesath, Joshua, Kaushal, Nidhi, Lam, Betty P, Amador-Arjona, Alejandro, Rahbaek, Lisa, McConn, Donavon J, Mulligan, Victoria J, Brice, Nicola, Gaskin, Philip L. R, Cilia, Jackie, Hitchcock, Stephen

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Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease von Barekatain, Mahta, Johansson, Linda C, Lam, Jordy H, Chang, Hao, Sadybekov, Anastasiia V, Han, Gye Won, Russo, Joseph, Bliesath, Joshua, Brice, Nicola L, Carlton, Mark B L, Saikatendu, Kumar S, Sun, Hukai, Murphy, Sean T, Monenschein, Holger, Schiffer, Hans H, Popov, Petr, Lutomski, Corinne A, Robinson, Carol V, Liu, Zhi-Jie, Hua, Tian, Katritch, Vsevolod, Cherezov, Vadim

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Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease von Brice, Nicola L., Schiffer, Hans H., Monenschein, Holger, Mulligan, Victoria J., Page, Keith, Powell, Justin, Xu, Xiao, Cheung, Toni, Burley, J. Russell, Sun, Huikai, Dickson, Louise, Murphy, Sean T., Kaushal, Nidhi, Sheardown, Steve, Lawrence, Jason, Chen, Yun, Bartkowski, Darian, Kanta, Anne, Russo, Joseph, Hosea, Natalie, Dawson, Lee A., Hitchcock, Stephen H., Carlton, Mark B.

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S39. GPR139 AN OPHAN GPCR AFFECTING NEGATIVE DOMAINS OF SCHIZOPHRENIA von Atienza, Joy, Reichard, Holly, Mulligan, Victoria, Cilia, Jackie, Monenschein, Holger, Collia, Deanna, Ray, Jim, Kilpatrick, Gavin, Brice, Nicola, Carlton, Mark, Hitchcock, Steve, Corbett, Ged

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Lithiated Dimethoxymethyl Diphenyl Phosphine Oxide, A Versatile Formiate Carbanion Equivalent von Monenschein, Holger, Brünjes, Marco, Kirschning, Andreas

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid von Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists von Horne, Daniel B, Tamayo, Nuria A, Bartberger, Michael D, Bo, Yunxin, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Kaller, Matthew R, Lehto, Sonya G, Ma, Vu V, Nishimura, Nobuko, Nguyen, Thomas T, Tang, Phi, Wang, Weiya, Youngblood, Beth D, Zhang, Maosheng, Gavva, Narender R, Monenschein, Holger, Norman, Mark H

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Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers von Horne, Daniel B., Bartberger, Michael D., Kaller, Matthew R., Monenschein, Holger, Zhong, Wenge, Hitchcock, Stephen A.

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Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility von Rzasa, Robert M., Frohn, Michael J., Andrews, Kristin L., Chmait, Samer, Chen, Ning, Clarine, Jeffrey G., Davis, Carl, Eastwood, Heather A., Horne, Daniel B., Hu, Essa, Jones, Adrie D., Kaller, Matthew R., Kunz, Roxanne K., Miller, Silke, Monenschein, Holger, Nguyen, Thomas, Pickrell, Alexander J., Porter, Amy, Reichelt, Andreas, Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors von Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Total Synthesis of Apoptolidin:  Completion of the Synthesis and Analogue Synthesis and Evaluation von Nicolaou, K. C, Li, Yiwei, Sugita, Kazuyuki, Monenschein, Holger, Guntupalli, Prasuna, Mitchell, Helen J, Fylaktakidou, Konstantina C, Vourloumis, Dionisios, Giannakakou, Paraskevi, O'Brate, Aurora

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