Mechanistic enzymology in drug discovery: a fresh perspective von Holdgate, Geoffrey A., Meek, Thomas D., Grimley, Rachel L.

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A perspective on the discovery of enzyme activators von Turberville, Antonia, Semple, Hannah, Davies, Gareth, Ivanov, Delyan, Holdgate, Geoffrey A.

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Measurements of binding thermodynamics in drug discovery von Holdgate, Geoffrey A., Ward, Walter H.J.

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Characterisation of high throughput screening outputs for small molecule degrader discovery von Bell, Lillie E., Bardelle, Catherine, Packer, Martin J, Kastl, Johanna, Holdgate, Geoffrey A., Davies, Gareth

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POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening von Lanne, Alice, Bardelle, Catherine, Davies, Gareth, Turberville, Antonia, Semple, Hannah, Moore, Rachel, Holdgate, Geoffrey A.

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Screening for molecular glues – Challenges and opportunities von Holdgate, Geoffrey A., Bardelle, Catherine, Berry, Sophia K., Lanne, Alice, Cuomo, Maria Emanuela

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Utilising acoustic mist ionisation mass spectrometry to identify redox cycling compounds in high throughput screening outputs von Moore, Rachel, Molyneux, Corinne, Sinclair, Ian, Holdgate, Geoffrey A., Walsh, Jarrod

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High-throughput detection of metal contamination in HTS outputs von Molyneux, Corinne, Sinclair, Ian, Lightfoot, Helen L., Walsh, Jarrod, Holdgate, Geoffrey A., Moore, Rachel

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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 von Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.

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High throughput screening of 0.5 million compounds against CRAF using Alpha CETSA von Rowlands, Hannah, Tschapalda, Kirsten, Blackett, Carolyn, Ivanov, Delyan, Plant, Darren, Shaw, Joseph, Thomas, Andrew, Packer, Martin, Arnold, Laurence, Holdgate, Geoffrey A.

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Drug discovery for epigenetics targets von Holdgate, Geoffrey A, Bardelle, Catherine, Lanne, Alice, Read, Jon, O'Donovan, Daniel H, Smith, James M, Selmi, Nidhal, Sheppard, Robert

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Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility von Wernersson, Sven, Bobby, Romel, Flavell, Liz, Milbradt, Alexander G., Holdgate, Geoffrey A., Embrey, Kevin J., Akke, Mikael

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Advancing automation in high-throughput screening: Modular unguarded systems enable adaptable drug discovery von Hansel, Catherine S., Plant, Darren L., Holdgate, Geoffrey A., Collier, Matthew J., Plant, Helen

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A perspective on the changing landscape of HTS von Lanne, Alice, Usselmann, Laura E J, Llowarch, Poppy, Michaelides, Iacovos N, Fillmore, Martin, Holdgate, Geoffrey A

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Hit me with your best shot: Integrated hit discovery for the next generation of drug targets von Ashraf, S. Neha, Blackwell, J. Henry, Holdgate, Geoffrey A., Lucas, Simon C.C., Solovyeva, Alisa, Storer, R. Ian, Whitehurst, Benjamin C.

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Small-Molecule Degraders beyond PROTACs—Challenges and Opportunities von Kastl, Johanna M., Davies, Gareth, Godsman, Eleanor, Holdgate, Geoffrey A.

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Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation von Ward, Richard A, Brassington, Claire, Breeze, Alexander L, Caputo, Alessandro, Critchlow, Susan, Davies, Gareth, Goodwin, Louise, Hassall, Giles, Greenwood, Ryan, Holdgate, Geoffrey A, Mrosek, Michael, Norman, Richard A, Pearson, Stuart, Tart, Jonathan, Tucker, Julie A, Vogtherr, Martin, Whittaker, David, Wingfield, Jonathan, Winter, Jon, Hudson, Kevin

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Thermal unfolding methods in drug discovery von Llowarch, Poppy, Usselmann, Laura, Ivanov, Delyan, Holdgate, Geoffrey A

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Applications of Biophysics in Early Drug Discovery von Holdgate, Geoffrey A., Bergsdorf, Christian

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Validation of ion mobility spectrometry - mass spectrometry as a screening tool to identify type II kinase inhibitors of FGFR1 kinase von Beeston, Helen S., Klein, Tobias, Norman, Richard A., Tucker, Julie A., Anderson, Malcolm, Ashcroft, Alison E., Holdgate, Geoffrey A.

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