Patient‐derived organoids, creating a new window of opportunities for pancreatic cancer patients von Sandhya, Sandhya, Hogenson, Tara L, Fernandez‐Zapico, Martin E

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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion von Gutierrez-Ruiz, Omar L., Johnson, Katherine M., Krueger, Eugene W., Nooren, Roseanne E., Cruz-Reyes, Nicole, Heppelmann, Carrie Jo, Hogenson, Tara L., Fernandez-Zapico, Martin E., McNiven, Mark A., Razidlo, Gina L.

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Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers von Hogenson, Tara L, Xie, Hao, Phillips, William J, Toruner, Merih D, Li, Jenny J, Horn, Isaac P, Kennedy, Devin J, Almada, Luciana L, Marks, David L, Carr, Ryan M, Toruner, Murat, Sigafoos, Ashley N, Koenig-Kappes, Amanda N, Olson, Rachel Lo, Tolosa, Ezequiel J, Zhang, Cheng, Li, Hu, Doles, Jason D, Bleeker, Jonathan, Barrett, Michael T, Boyum, James H, Kipp, Benjamin R, Mahipal, Amit, Hubbard, Joleen M, Scheffler Hanson, Temperance J, Petersen, Gloria M, Dasari, Surendra, Oberg, Ann L, Truty, Mark J, Graham, Rondell P, Levy, Michael J, Zhu, Mojun, Billadeau, Daniel D, Adjei, Alex A, Dusetti, Nelson, Iovanna, Juan L, Bekaii-Saab, Tanios S, Ma, Wen Wee, Fernandez-Zapico, Martin E

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Anticachectic regulator analysis reveals Perp-dependent antitumorigenic properties of 3-methyladenine in pancreatic cancer von Dasgupta, Aneesha, Arneson-Wissink, Paige C, Schmitt, Rebecca E, Cho, Dong Seong, Ducharme, Alexandra M, Hogenson, Tara L, Krueger, Eugene W, Bamlet, William R, Zhang, Lizhi, Razidlo, Gina L, Fernandez-Zapico, Martin E, Doles, Jason D

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Development of SOS1 Inhibitor-Based Degraders to Target KRAS-Mutant Colorectal Cancer von Bian, Yujia, Alem, Diego, Beato, Francisca, Hogenson, Tara L., Yang, Xinrui, Jiang, Kun, Cai, Jianfeng, Ma, Wen Wee, Fernandez-Zapico, Martin, Tan, Aik Choon, Lawrence, Nicholas J., Fleming, Jason B., Yuan, Yu, Xie, Hao

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Irreversible JNK blockade overcomes PD-L1-mediated resistance to chemotherapy in colorectal cancer von Sun, Lei, Patai, Árpád V., Hogenson, Tara L., Fernandez-Zapico, Martin E., Qin, Bo, Sinicrope, Frank A.

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GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression von Tolosa, Ezequiel J., Fernandez-Barrena, Maite G., Iguchi, Eriko, McCleary-Wheeler, Angela L., Carr, Ryan M., Almada, Luciana L., Flores, Luis F., Vera, Renzo E., Alfonse, Germine W., Marks, David L., Hogenson, Tara L., Vrabel, Anne M., Horn, Isaac P., Koenig, Amanda N., Safgren, Stephanie L., Sigafoos, Ashley N., Erkan, Mert, Romecin-Duran, Paola A., Gonzalez, Alejandro Sarabia, Zhou, Bo, Javelaud, Delphine, Marsaud, Veronique, Graham, Rondell P., Mauviel, Alain, Elsawa, Sherine F., Fernandez-Zapico, Martin E.

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Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas von Lenkiewicz, Elizabeth, Malasi, Smriti, Hogenson, Tara L., Flores, Luis F., Barham, Whitney, Phillips, William J., Roesler, Alexander S., Chambers, Kendall R., Rajbhandari, Nirakar, Hayashi, Akimasa, Antal, Corina E., Downes, Michael, Grandgenett, Paul M., Hollingsworth, Michael A., Cridebring, Derek, Xiong, Yuning, Lee, Jeong-Heon, Ye, Zhenqing, Yan, Huihuang, Hernandez, Matthew C., Leiting, Jennifer L., Evans, Ronald M., Ordog, Tamas, Truty, Mark J., Borad, Mitesh J., Reya, Tannishtha, Von Hoff, Daniel D., Fernandez-Zapico, Martin E., Barrett, Michael T.

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Phase II Trial of Trifluridine/Tipiracil Plus Irinotecan in Patients with Advanced, Refractory Biliary Tract Carcinoma von Tella, Sri Harsha, Foster, Nathan, Qian, Shi, Nguyen, Tran, Borad, Mitesh J, McWilliams, Robert R, Alberts, Steven R, Wee Ma, Wen, Chakrabarti, Sakti, Fruth, Briant, Wessling, Jaclynn, Hartgers, Mindy, Washburn, Leslie, Fernandez-Zapico, Martin E, Hogenson, Tara L, Pitot, Henry, Jin, Zhaohui, Mahipal, Amit

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Translational relevance of SOS1 targeting for KRAS‐mutant colorectal cancer von Alem, Diego, Yang, Xinrui, Beato, Francisca, Sarcar, Bhaswati, Tassielli, Alexandra F., Dai, Ruifan, Hogenson, Tara L., Park, Margaret A., Jiang, Kun, Cai, Jianfeng, Yuan, Yu, Fernandez‐Zapico, Martin E., Tan, Aik Choon, Fleming, Jason B., Xie, Hao

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A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition von Horn, Isaac P., Marks, David L., Koenig, Amanda N., Hogenson, Tara L., Almada, Luciana L., Goldstein, Lauren E., Romecin Duran, Paola A., Vera, Renzo, Vrabel, Anne M., Cui, Gaofeng, Rabe, Kari G., Bamlet, William R., Mer, Georges, Sicotte, Hugues, Zhang, Cheng, Li, Hu, Petersen, Gloria M., Fernandez-Zapico, Martin E.

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Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis [version 2; peer review: 3 approved] von Hogenson, Tara L, Lauth, Matthias, Pasca diMagliano, Marina, Fernandez-Zapico, Martin E

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KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis von Sigafoos, Ashley N, Tolosa, Ezequiel J, Carr, Ryan M, Fernandez-Barrena, Maite G, Almada, Luciana L, Pease, David R, Hogenson, Tara L, Raja Arul, Glancis L, Mousavi, Fatemeh, Sen, Sandhya, Vera, Renzo E, Marks, David L, Flores, Luis F, LaRue-Nolan, Kayla C, Wu, Chen, Bamlet, William R, Vrabel, Anne M, Sicotte, Hugues, Schenk, Erin L, Smyrk, Thomas C, Zhang, Lizhi, Rabe, Kari G, Oberg, Ann L, Zaphiropoulos, Peter G, Chevet, Eric, Graham, Rondell P, Hagen, Catherine E, di Magliano, Marina P, Elsawa, Sherine F, Pin, Christopher L, Mao, Junhao, McWilliams, Robert R, Fernandez-Zapico, Martin E

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Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis von Hogenson, Tara L, Lauth, Matthias, Pasca diMagliano, Marina, Fernandez-Zapico, Martin E

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Abstract 1085: PD-L1-mediated resistance to chemotherapy is overcome by an irreversible JNK inhibitor in colorectal cancer cells von Sinicrope, Frank A., Sun, Lei, Patai, Arpad, Hogenson, Tara L., Fernandez-Zapico, Martin E., Qin, Bo

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Phase II trial of trifluridine/tipiracil and irinotecan for the treatment of advanced refractory biliary tract cancer von Xie, Hao, Borad, Mitesh J., Ahn, Daniel H., Bekaii-Saab, Tanios S., Tran, Nguyen H., Jin, Zhaohui, Pitot, Henry C., Huebner, Lucas J., Shi, Qian, Wessling, Jaclynn, Durgin, Lori M., Liu, Minetta C., Hogenson, Tara L., Phillips, William J, Fernandez-Zapico, Martin, Alberts, Steven R, Mahipal, Amit

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Patient-derived organoid (PDO), a new personalized therapy selection tool for prompt clinical decision making in metastatic gastrointestinal (mGI) cancer patients von Xie, Hao, Hogenson, Tara L, Horn, Isaac P, Almada, Luciana, Marks, David, Koenig, Amanda, Tolosa, Ezequiel, Barrett, Michael T., Boyum, James H, Mahipal, Amit, Hubbard, Joleen Marie, Scheffler Hanson, Temperance J, Yin, Jun, Petersen, Gloria M., Revzin, Alexander, Billadeau, Daniel D., Bekaii-Saab, Tanios S., Adjei, Alex A., Ma, Wen Wee, Fernandez-Zapico, Martin

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Epigenetics as the Underlying Mechanism for Monozygotic Twin Discordance von Hogenson, Tara L.

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Abstract 3995: Identification of perp as a tumor promoter in pancreatic cancer via the utilization of an aged model of cancer cachexia von Dasgupta, Aneesha, Arneson-Wissink, Paige C., Schmitt, Rebecca E., Cho, Dong Seong, Ducharme, Alexandra M., Hogenson, Tara L., Krueger, Eugene W., Bamlet, William R., Zhang, Lizhi, Razidlo, Gina, Fernandez-Zapico, Martin E., Doles, Jason D.

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