Therapy resistance mechanisms in hematological malignancies von Hofmann, Wolf‐Karsten, Trumpp, Andreas, Müller‐Tidow, Carsten

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Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics von Velten, Lars, Story, Benjamin A., Hernández-Malmierca, Pablo, Raffel, Simon, Leonce, Daniel R., Milbank, Jennifer, Paulsen, Malte, Demir, Aykut, Szu-Tu, Chelsea, Frömel, Robert, Lutz, Christoph, Nowak, Daniel, Jann, Johann-Christoph, Pabst, Caroline, Boch, Tobias, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Trumpp, Andreas, Haas, Simon, Steinmetz, Lars M.

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Human haematopoietic stem cell lineage commitment is a continuous process von Velten, Lars, Haas, Simon F., Raffel, Simon, Blaszkiewicz, Sandra, Islam, Saiful, Hennig, Bianca P., Hirche, Christoph, Lutz, Christoph, Buss, Eike C., Nowak, Daniel, Boch, Tobias, Hofmann, Wolf-Karsten, Ho, Anthony D., Huber, Wolfgang, Trumpp, Andreas, Essers, Marieke A. G., Steinmetz, Lars M.

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Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial von Saussele, Susanne, Richter, Johan, Guilhot, Joelle, Gruber, Franz X, Hjorth-Hansen, Henrik, Almeida, Antonio, Janssen, Jeroen J W M, Mayer, Jiri, Koskenvesa, Perttu, Panayiotidis, Panayiotis, Olsson-Strömberg, Ulla, Martinez-Lopez, Joaquin, Rousselot, Philippe, Vestergaard, Hanne, Ehrencrona, Hans, Kairisto, Veli, Machová Poláková, Katerina, Müller, Martin C, Mustjoki, Satu, Berger, Marc G, Fabarius, Alice, Hofmann, Wolf-Karsten, Hochhaus, Andreas, Pfirrmann, Markus, Mahon, Francois-Xavier, Ossenkoppele, Gert, Pagoni, Maria N., Söderlund, Stina, Escoffre-Barbe, Martine, Etienne, Gabriel, Dengler, Jolanta, Huguet, Francoise, von Bubnoff, Nikolas, Klamova, Hana, Faber, Edgar, Guilhot, Francois, Lotfi, Kourosh, Rea, Delphine, Brümmendorf, Tim H., de Greef, Gorgine E., Stenke, Leif, Nicolini, Franck E., Legros, Laurence, Burchert, Andreas, Voglova, Jaroslava, Charbonnier, Aude, Gyan, Emmanuel, Kunzmann, Volker, Westerweel, Peter E.

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states von Triana, Sergio, Vonficht, Dominik, Jopp-Saile, Lea, Raffel, Simon, Lutz, Raphael, Leonce, Daniel, Antes, Magdalena, Hernández-Malmierca, Pablo, Ordoñez-Rueda, Diana, Ramasz, Beáta, Boch, Tobias, Jann, Johann-Christoph, Nowak, Daniel, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Hübschmann, Daniel, Alexandrov, Theodore, Benes, Vladimir, Trumpp, Andreas, Paulsen, Malte, Velten, Lars, Haas, Simon

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The insertion site is the main risk factor for central venous catheter‐related complications in patients with hematologic malignancies von Heidenreich, Daniela, Hansen, Eleonore, Kreil, Sebastian, Nolte, Florian, Jawhar, Mohamad, Hecht, Anna, Hofmann, Wolf‐Karsten, Klein, Stefan A.

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Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1‐JAK2, BCR‐JAK2 and ETV6‐ABL1 fusion genes von Schwaab, Juliana, Naumann, Nicole, Luebke, Johannes, Jawhar, Mohamad, Somervaille, Tim C.P., Williams, Mark S., Frewin, Rebecca, Jost, Philipp J., Lichtenegger, Felix S., La Rosée, Paul, Storch, Nicola, Haferlach, Torsten, Horny, Hans‐Peter, Fabarius, Alice, Haferlach, Claudia, Burchert, Andreas, Hofmann, Wolf‐Karsten, Cross, Nicholas C.P., Hochhaus, Andreas, Reiter, Andreas, Metzgeroth, Georgia

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Frequent pathway mutations of splicing machinery in myelodysplasia von Yoshida, Kenichi, Sanada, Masashi, Shiraishi, Yuichi, Nowak, Daniel, Nagata, Yasunobu, Yamamoto, Ryo, Sato, Yusuke, Sato-Otsubo, Aiko, Kon, Ayana, Nagasaki, Masao, Chalkidis, George, Suzuki, Yutaka, Shiosaka, Masashi, Kawahata, Ryoichiro, Yamaguchi, Tomoyuki, Otsu, Makoto, Obara, Naoshi, Sakata-Yanagimoto, Mamiko, Ishiyama, Ken, Mori, Hiraku, Nolte, Florian, Hofmann, Wolf-Karsten, Miyawaki, Shuichi, Sugano, Sumio, Haferlach, Claudia, Koeffler, H. Phillip, Shih, Lee-Yung, Haferlach, Torsten, Chiba, Shigeru, Nakauchi, Hiromitsu, Miyano, Satoru, Ogawa, Seishi

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Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo von Jann, Johann-Christoph, Mossner, Maximilian, Riabov, Vladimir, Altrock, Eva, Schmitt, Nanni, Flach, Johanna, Xu, Qingyu, Nowak, Verena, Obländer, Julia, Palme, Iris, Weimer, Nadine, Streuer, Alexander, Jawhar, Ahmed, Darwich, Ali, Jawhar, Mohammad, Metzgeroth, Georgia, Nolte, Florian, Hofmann, Wolf-Karsten, Nowak, Daniel

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Incidence and prognostic impact of cytogenetic aberrations in patients with systemic mastocytosis von Naumann, Nicole, Jawhar, Mohamad, Schwaab, Juliana, Kluger, Sebastian, Lübke, Johannes, Metzgeroth, Georgia, Popp, Henning D., Khaled, Nada, Horny, Hans‐Peter, Sotlar, Karl, Valent, Peter, Haferlach, Claudia, Göhring, Gudrun, Schlegelberger, Brigitte, Meggendorfer, Manja, Hofmann, Wolf‐Karsten, Cross, Nicholas C.P., Reiter, Andreas, Fabarius, Alice

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Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms von Kon, Ayana, Shih, Lee-Yung, Minamino, Masashi, Sanada, Masashi, Shiraishi, Yuichi, Nagata, Yasunobu, Yoshida, Kenichi, Okuno, Yusuke, Bando, Masashige, Nakato, Ryuichiro, Ishikawa, Shumpei, Sato-Otsubo, Aiko, Nagae, Genta, Nishimoto, Aiko, Haferlach, Claudia, Nowak, Daniel, Sato, Yusuke, Alpermann, Tamara, Nagasaki, Masao, Shimamura, Teppei, Tanaka, Hiroko, Chiba, Kenichi, Yamamoto, Ryo, Yamaguchi, Tomoyuki, Otsu, Makoto, Obara, Naoshi, Sakata-Yanagimoto, Mamiko, Nakamaki, Tsuyoshi, Ishiyama, Ken, Nolte, Florian, Hofmann, Wolf-Karsten, Miyawaki, Shuichi, Chiba, Shigeru, Mori, Hiraku, Nakauchi, Hiromitsu, Koeffler, H Phillip, Aburatani, Hiroyuki, Haferlach, Torsten, Shirahige, Katsuhiko, Miyano, Satoru, Ogawa, Seishi

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Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells von Doebele, Carmen, Bonauer, Angelika, Fischer, Ariane, Scholz, Alexander, Reiss, Yvonne, Urbich, Carmen, Hofmann, Wolf-Karsten, Zeiher, Andreas M., Dimmeler, Stefanie

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Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 (JAK2) V617F and KIT proto‐oncogene, receptor tyrosine kinase (KIT) D816V mutations von Naumann, Nicole, Lübke, Johannes, Shomali, William, Reiter, Lukas, Horny, Hans‐Peter, Jawhar, Mohamad, Dangelo, Vito, Fabarius, Alice, Metzgeroth, Georgia, Kreil, Sebastian, Sotlar, Karl, Oni, Claire, Harrison, Claire, Hofmann, Wolf‐Karsten, Cross, Nicholas C. P., Valent, Peter, Radia, Deepti, Gotlib, Jason, Reiter, Andreas, Schwaab, Juliana

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Comprehensive mutational profiling in advanced systemic mastocytosis von Schwaab, Juliana, Schnittger, Susanne, Sotlar, Karl, Walz, Christoph, Fabarius, Alice, Pfirrmann, Markus, Kohlmann, Alexander, Grossmann, Vera, Meggendorfer, Manja, Horny, Hans-Peter, Valent, Peter, Jawhar, Mohamad, Teichmann, Martina, Metzgeroth, Georgia, Erben, Philipp, Ernst, Thomas, Hochhaus, Andreas, Haferlach, Torsten, Hofmann, Wolf-Karsten, Cross, Nicholas C.P., Reiter, Andreas

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A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage von Wang, Jianwei, Sun, Qian, Morita, Yohei, Jiang, Hong, Groß, Alexander, Lechel, André, Hildner, Kai, Guachalla, Luis Miguel, Gompf, Anne, Hartmann, Daniel, Schambach, Axel, Wuestefeld, Torsten, Dauch, Daniel, Schrezenmeier, Hubert, Hofmann, Wolf-Karsten, Nakauchi, Hiromitsu, Ju, Zhenyu, Kestler, Hans A., Zender, Lars, Rudolph, K. Lenhard

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Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations von Flach, Johanna, Jann, Johann-Christoph, Knaflic, Antje, Riabov, Vladimir, Streuer, Alexander, Altrock, Eva, Xu, Qingyu, Schmitt, Nanni, Obländer, Julia, Nowak, Verena, Danner, Justine, Mehralivand, Arwin, Hofmann, Franziska, Palme, Iris, Jawhar, Ahmed, Wuchter, Patrick, Metzgeroth, Georgia, Nolte, Florian, Hofmann, Wolf-Karsten, Nowak, Daniel

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Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV von Fabarius, Alice, Leitner, Armin, Hochhaus, Andreas, Müller, Martin C., Hanfstein, Benjamin, Haferlach, Claudia, Göhring, Gudrun, Schlegelberger, Brigitte, Jotterand, Martine, Reiter, Andreas, Jung-Munkwitz, Susanne, Proetel, Ulrike, Schwaab, Juliana, Hofmann, Wolf-Karsten, Schubert, Jörg, Einsele, Hermann, Ho, Anthony D., Falge, Christiane, Kanz, Lothar, Neubauer, Andreas, Kneba, Michael, Stegelmann, Frank, Pfreundschuh, Michael, Waller, Cornelius F., Spiekermann, Karsten, Baerlocher, Gabriela M., Lauseker, Michael, Pfirrmann, Markus, Hasford, Joerg, Saussele, Susanne, Hehlmann, Rüdiger

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Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions von Valent, Peter, Orazi, Attilio, Steensma, David P, Ebert, Benjamin L, Haase, Detlef, Malcovati, Luca, van de Loosdrecht, Arjan A, Haferlach, Torsten, Westers, Theresia M, Wells, Denise A, Giagounidis, Aristoteles, Loken, Michael, Orfao, Alberto, Lübbert, Michael, Ganser, Arnold, Hofmann, Wolf-Karsten, Ogata, Kiyoyuki, Schanz, Julie, Béné, Marie C, Hoermann, Gregor, Sperr, Wolfgang R, Sotlar, Karl, Bettelheim, Peter, Stauder, Reinhard, Pfeilstöcker, Michael, Horny, Hans-Peter, Germing, Ulrich, Greenberg, Peter, Bennett, John M

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Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis von Lübke, Johannes, Naumann, Nicole, Kluger, Sebastian, Schwaab, Juliana, Metzgeroth, Georgia, Evans, Erica, Gardino, Alexandra K., Lengauer, Christoph, Hofmann, Wolf-Karsten, Fabarius, Alice, Cross, Nicholas C. P., Reiter, Andreas, Jawhar, Mohamad

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Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia... von HAFERLACH, Torsten, KOHLMANN, Alexander, GILKES, Amanda, CHIARETTI, Sabina, SHURTLEFF, Sheila A, KIPPS, Thomas J, RASSENTI, Laura Z, YEOH, Allen E, PAPENHAUSEN, Peter R, LIU, Wei-Min, WILLIAMS, P. Mickey, FOA, Robin, WIECZOREK, Lothar, BASSO, Giuseppe, TE KRONNIE, Geertruy, BONO, Marie-Christine, DE VOS, John, HERNINDEZ, Jesus M, HOFMANN, Wolf-Karsten, MILLS, Ken I

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