GCT-23. MULTI-INSTITUTIONAL ANALYSIS OF TREATMENT MODALITIES IN BASAL GANGLIA AND THALAMIC GERMINOMA von Graham, Richard T, Abu-Arja, Mohammad H, Stanek, Joseph, Bartels, Ute, Cappellano, Andrea, Chi, Susan, Cooney, Tabitha, Dhall, Girish, Finlay, Jonathan L, Fisher, Michael J, Friedman, Gregory, Gajjar, Amar, Gauvain, Karen, Hoffmann, Lindsey M, Hukin, Juliette, Margol, Ashley, Mueller, Sabine, Navalkele, Pournima, Ronsley, Rebecca, Villeneuve, Stephanie, Yeo, Kee Kiat, Su, Jack M, Gottardo, Nicholas G, Allen, Jeffrey, Packer, Roger, AbdelBaki, Mohamed

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Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and... von Hoffman, Lindsey M, Veldhuijzen van Zanten, Sophie E M, Colditz, Niclas, Baugh, Joshua, Chaney, Brooklyn, Hoffmann, Marion, Lane, Adam, Fuller, Christine, Miles, Lili, Hawkins, Cynthia, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah, Foreman, Nicholas K, Packer, Roger, Warren, Katherine E, Broniscer, Alberto, Kieran, Mark W, Minturn, Jane, Comito, Melanie, Broxson, Emmett, Shih, Chie-Schin, Khatua, Soumen, Chintagumpala, Murali, Carret, Anne Sophie, Escorza, Nancy Yanez, Hassall, Timothy, Ziegler, David S, Gottardo, Nicholas, Dholaria, Hetal, Doughman, Renee, Benesch, Martin, Drissi, Rachid, Nazarian, Javad, Jabado, Nada, Boddaert, Nathalie, Varlet, Pascale, Giraud, Géraldine, Castel, David, Puget, Stephanie, Jones, Chris, Hulleman, Esther, Modena, Piergiorgio, Giagnacovo, Marzia, Antonelli, Manila, Pietsch, Torsten, Gielen, Gerrit H, Jones, David T W, Sturm, Dominik, Pfister, Stefan M, Gerber, Nicolas U, Grotzer, Michael A, Pfaff, Elke, von Bueren, André O, Hargrave, Darren, Solanki, Guirish A, Jadrijevic Cvrlje, Filip, Kaspers, Gertjan J L, Vandertop, William P, Grill, Jacques, Bailey, Simon, Biassoni, Veronica, Massimino, Maura, Calmon, Raphaël, Sanchez, Esther, Bison, Brigitte, Warmuth-Metz, Monika, Leach, James, Jones, Blaise, van Vuurden, Dannis G, Kramm, Christof M, Fouladi, Maryam

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Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease von Lewis, James D., Chen, Eric Z., Baldassano, Robert N., Otley, Anthony R., Griffiths, Anne M., Lee, Dale, Bittinger, Kyle, Bailey, Aubrey, Friedman, Elliot S., Hoffmann, Christian, Albenberg, Lindsey, Sinha, Rohini, Compher, Charlene, Gilroy, Erin, Nessel, Lisa, Grant, Amy, Chehoud, Christel, Li, Hongzhe, Wu, Gary D., Bushman, Frederic D.

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Complement genes contribute sex-biased vulnerability in diverse disorders von Kamitaki, Nolan, Sekar, Aswin, Handsaker, Robert E., de Rivera, Heather, Tooley, Katherine, Morris, David L., Taylor, Kimberly E., Whelan, Christopher W., Tombleson, Philip, Loohuis, Loes M. Olde, Boehnke, Michael, Kimberly, Robert P., Kaufman, Kenneth M., Harley, John B., Langefeld, Carl D., Seidman, Christine E., Pato, Michele T., Pato, Carlos N., Ophoff, Roel A., Graham, Robert R., Criswell, Lindsey A., Vyse, Timothy J., McCarroll, Steven A.

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Supporting the adaptive capacity of species through more effective knowledge exchange with conservation practitioners von Cook, Carly N., Beever, Erik A., Thurman, Lindsey L., Thompson, Laura M., Gross, John E., Whiteley, Andrew R., Nicotra, Adrienne B., Szymanski, Jennifer A., Botero, Carlos A., Hall, Kimberly R., Hoffmann, Ary A., Schuurman, Gregor W., Sgrò, Carla M.

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Connecting research and practice to enhance the evolutionary potential of species under climate change von Thompson, Laura M., Thurman, Lindsey L., Cook, Carly N., Beever, Erik A., Sgrò, Carla M., Battles, Andrew, Botero, Carlos A., Gross, John E., Hall, Kimberly R., Hendry, Andrew P., Hoffmann, Ary A., Hoving, Christopher, LeDee, Olivia E., Mengelt, Claudia, Nicotra, Adrienne B., Niver, Robyn A., Pérez‐Jvostov, Felipe, Quiñones, Rebecca M., Schuurman, Gregor W., Schwartz, Michael K., Szymanski, Jennifer, Whiteley, Andrew

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Use of Whole Genome Sequencing by the Federal Interagency Collaboration for Genomics for Food and Feed Safety in the United States von Stevens, Eric L, Carleton, Heather A, Beal, Jennifer, Tillman, Glenn E, Lindsey, Rebecca L, Lauer, A C, Pightling, Arthur, Jarvis, Karen G, Ottesen, Andrea, Ramachandran, Padmini, Hintz, Leslie, Katz, Lee S, Folster, Jason P, Whichard, Jean M, Trees, Eija, Timme, Ruth E, McDERMOTT, Patrick, Wolpert, Beverly, Bazaco, Michael, Zhao, Shaohua, Lindley, Sabina, Bruce, Beau B, Griffin, Patricia M, Brown, Eric, Allard, Marc, Tallent, Sandra, Irvin, Kari, Hoffmann, Maria, Wise, Matt, Tauxe, Robert, Gerner-Smidt, Peter, Simmons, Mustafa, Kissler, Bonnie, Defibaugh-Chavez, Stephanie, Klimke, William, Agarwala, Richa, Lindsay, James, Cook, Kimberly, Austerman, Suelee Robbe, Goldman, David, McGARRY, Sherri, Hale, Kis Robertson, Dessai, Uday, Musser, Steven M, Braden, Chris

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An APRI+ALBI Based Multivariable Model as Preoperative Predictor for Posthepatectomy Liver Failure von Santol, Jonas, Kim, Sarang, Gregory, Lindsey A, Baumgartner, Ruth, Murtha-Lemekhova, Anastasia, Birgin, Emrullah, Gloor, Severin, Braunwarth, Eva, Ammann, Markus, Starlinger, Johannes, Pereyra, David, Ammon, Daphni, Ninkovic, Marijana, Kern, Anna E, Rumpf, Benedikt, Ortmayr, Gregor, Herrmann, Yannic, Dong, Yawen, Huber, Felix X, Weninger, Jeremias, Thiels, Cornelius A, Warner, Susanne G, Smoot, Rory L, Truty, Mark J, Kendrick, Michael L, Nagorney, David N, Cleary, Sean P, Beldi, Guido, Rahbari, Nuh N, Hoffmann, Katrin, Gilg, Stefan, Assinger, Alice, Gruenberger, Thomas, Hackl, Hubert, Starlinger, Patrick

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Saving the World’s Terrestrial Megafauna von RIPPLE, WILLIAM J., CHAPRON, GUILLAUME, LÓPEZ-BAO, JOSÉ VICENTE, DURANT, SARAH M., MACDONALD, DAVID W., LINDSEY, PETER A., BENNETT, ELIZABETH L., BESCHTA, ROBERT L., BRUSKOTTER, JEREMY T., CAMPOS-ARCEIZ, AHIMSA, CORLETT, RICHARD T., DARIMONT, CHRIS T., DICKMAN, AMY J., DIRZO, RODOLFO, DUBLIN, HOLLY T., ESTES, JAMES A., EVERATT, KRISTOFFER T., GALETTI, MAURO, GOSWAMI, VARUN R., HAYWARD, MATT W., HEDGES, SIMON, HOFFMANN, MICHAEL, HUNTER, LUKE T. B., KERLEY, GRAHAM I. H., LETNIC, MIKE, LEVI, TAAL, MAISELS, FIONA, MORRISON, JOHN C., NELSON, MICHAEL PAUL, NEWSOME, THOMAS M., PAINTER, LUKE, PRINGLE, ROBERT M., SANDOM, CHRISTOPHER J., TERBORGH, JOHN, TREVES, ADRIAN, VALKENBURGH, BLAIRE VAN, VUCETICH, JOHN A., WIRSING, AARON J., WALLACH, ARIAN D., WOLF, CHRISTOPHER, WOODROFFE, ROSIE, YOUNG, HILLARY, ZHANG, LI

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Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease von Lewis, James D., Chen, Eric Z., Baldassano, Robert N., Otley, Anthony R., Griffiths, Anne M., Lee, Dale, Bittinger, Kyle, Bailey, Aubrey, Friedman, Elliot S., Hoffmann, Christian, Albenberg, Lindsey, Sinha, Rohini, Compher, Charlene, Gilroy, Erin, Nessel, Lisa, Grant, Amy, Chehoud, Christel, Li, Hongzhe, Wu, Gary D., Bushman, Frederic D.

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Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I-III Triple-negative Breast Cancer (NeoSTOP) von Sharma, Priyanka, Kimler, Bruce F., O'Dea, Anne, Nye, Lauren, Wang, Yen Y., Yoder, Rachel, Staley, Joshua M., Prochaska, Lindsey, Wagner, Jamie, Amin, Amanda L., Larson, Kelsey, Balanoff, Christa, Elia, Manana, Crane, Gregory, Madhusudhana, Sheshadri, Hoffmann, Marc, Sheehan, Maureen, Rodriguez, Roberto, Finke, Karissa, Shah, Rajvi, Satelli, Deepti, Shrestha, Anuj, Beck, Larry, McKittrick, Richard, Pluenneke, Robert, Raja, Vinay, Beeki, Venkatadri, Corum, Larry, Heldstab, Jaimie, LaFaver, Stephanie, Prager, Micki, Phadnis, Milind, Mudaranthakam, Dinesh Pal, Jensen, Roy A., Godwin, Andrew K., Salgado, Roberto, Mehta, Kathan, Khan, Qamar

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A First-in-Human Phase 1 Study of Oral LOXO-338, a Selective BCL2 Inhibitor, in Patients with Advanced Hematologic Malignancies (Trial in Progress) von Alencar, Alvaro J., Roeker, Lindsey E., Hoffmann, Marc, Guru Murthy, Guru Subramanian, Patel, Vishalkumar, Ku, Nora C., Pauff, James M., Eyre, Toby A., Jurczak, Wojciech, Le Gouill, Steven

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A first-in-human phase 1 study of oral LOXO-338, a selective BCL2 inhibitor, in patients with advanced hematologic malignancies (trial in progress) von Roeker, Lindsey Elizabeth, Alencar, Alvaro Jose, Guru Murthy, Guru Subramanian, Hoffmann, Marc Steven, Pagel, John M., Patel, Vishalkumar, Pauff, James Michael, Zinzani, Pier Luigi, Le Gouill, Steven, Mato, Anthony, Jurczak, Wojciech

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Pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in patients with B-cell malignancies: analysis of the Richter transformation subgroup from the multicentr... von Wierda, William G, Shah, Nirav N, Cheah, Chan Y, Lewis, David, Hoffmann, Marc S, Coombs, Catherine C, Lamanna, Nicole, Ma, Shuo, Jagadeesh, Deepa, Munir, Talha, Wang, Yucai, Eyre, Toby A, Rhodes, Joanna M, McKinney, Matthew, Lech-Maranda, Ewa, Tam, Constantine S, Jurczak, Wojciech, Izutsu, Koji, Alencar, Alvaro J, Patel, Manish R, Seymour, John F, Woyach, Jennifer A, Thompson, Philip A, Abada, Paolo B, Ho, Caleb, McNeely, Samuel C, Marella, Narasimha, Nguyen, Bastien, Wang, Chunxiao, Ruppert, Amy S, Nair, Binoj, Liu, Hui, Tsai, Donald E, Roeker, Lindsey E, Ghia, Paolo

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OS-050-YI - APRI+ALBI score is superior to Indocyanine Green (ICG) clearance and LiMAx test in the prediction of posthepatectomy liver failure-an international multicenter study of... von Santol, Jonas, Kim, Sarang, Hackl, Hubert, Gregory, Lindsey, Baumgartner, Ruth, Lemekhova, Anastasia, Birgin, Emrullah, Gloor, Severin, Braunwarth, Eva, Ammann, Markus, Starlinger, Johannes, Pereyra, David, Ammon, Daphni, Ninkovic, Marijana, Kern, Anna, Huber, Felix, Weninger, Jeremias, Dong, Yawen, Thiels, Cornelius, Warner, Susanne, Smoot, Rory L., Truty, Mark, Kendrick, Michael, Nagorney, David M., Cleary, Sean, Hoffmann, Katrin, Gilg, Stefan, Assinger, Alice, Grünberger, Thomas, Starlinger, Patrick

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APRI+ALBI score is superior to Indocyanine Green (ICG) clearance and LiMAx test in the prediction of posthepatectomy liver failure-an international multicenter study of 14581 patie... von Santol, Jonas, Kim, Sarang, Hackl, Hubert, Gregory, Lindsey, Baumgartner, Ruth, Lemekhova, Anastasia, Birgin, Emrullah, Gloor, Severin, Braunwarth, Eva, Ammann, Markus, Starlinger, Johannes, Pereyra, David, Ammon, Daphni, Ninkovic, Marijana, Kern, Anna, Huber, Felix, Weninger, Jeremias, Dong, Yawen, Thiels, Cornelius, Warner, Susanne, Smoot, Rory L., Truty, Mark, Kendrick, Michael, Nagorney, David M., Cleary, Sean, Hoffmann, Katrin, Gilg, Stefan, Assinger, Alice, Grünberger, Thomas, Starlinger, Patrick

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Pirtobrutinib in Richter Transformation: Updated Efficacy and Safety Results with 18-Month Median Survival Follow-up from the Phase 1/2 BRUIN Study von Wierda, William G., Shah, Nirav N., Cheah, Chan Yoon, Lewis, David, Hoffmann, Marc S., Coombs, Catherine C., Lamanna, Nicole, Ma, Shuo, Jagadeesh, Deepa, Munir, Talha, Wang, Yucai, Eyre, Toby A., Rhodes, Joanna M., McKinney, Matthew, Lech-Maranda, Ewa, Tam, Constantine S., Jurczak, Wojciech, Izutsu, Koji, Alencar, Alvaro J., Patel, Manish, Seymour, John F., Woyach, Jennifer A., Roeker, Lindsey E., Thompson, Philip A., Abada, Paolo, Ho, Caleb, Marella, Narasimha, Wang, Chunxiao, Ruppert, Amy S., Chandrasekharan Nair, Binoj, Liu, Hui, Tsai, Donald E., Ghia, Paolo

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Pirtobrutinib in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) Patients with Prior cBTKi: Safety and Efficacy Including High-Risk Subgroup Analyses from the Phase 1/2 BRUIN... von Cohen, Jonathon B., Shah, Nirav N., Jurczak, Wojciech, Zinzani, Pier Luigi, Cheah, Chan Y., Eyre, Toby A., Ujjani, Chaitra S, Koh, Youngil, Kim, Won Seog, Nasta, Sunita D., Flinn, Ian W., Tessoulin, Benoit, Ma, Shuo, Alencar, Alvaro J., Lewis, David, Woyach, Jennifer A., Maddocks, Kami J., Patel, Krish, Wang, Yucai, Rhodes, Joanna M., Tam, Constantine S., Seymour, John F., Nagai, Hirokazu, Vose, Julie M., Fakhri, Bita, Hoffmann, Marc S., Hernandez-Ilizaliturri, Francisco J., Zelenetz, Andrew D., Kumar, Anita, Munir, Talha, Tsai, Donald E., Balbas, Minna, Liu, Bin, Ruppert, Amy S., Nguyen, Bastien, Roeker, Lindsey E., Wang, Michael L.

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Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma von Hohm, Annika, Karremann, Michael, Gielen, Gerrit H., Pietsch, Torsten, Warmuth-Metz, Monika, Vandergrift, Lindsey A., Bison, Brigitte, Stock, Annika, Hoffmann, Marion, Pham, Mirko, Kramm, Christof M., Nowak, Johannes

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P636: A FIRST‐IN‐HUMAN PHASE 1 STUDY OF ORAL LOXO‐338, A SELECTIVE BCL2 INHIBITOR, IN PATIENTS WITH ADVANCED HEMATOLOGIC MALIGNANCIES von Kwiatek, Michal, Subramanian Guru Murthy, Guru, Hoffmann, Marc, Roeker, Lindsey, Tessoulin, Benoit, Danilov, Alexey, Alencar, Alvaro J., Shah, Nirav N., Ghesquieres, Herve, Le Gouill, Steven, Jurczak, Wojciech, R. Mato, Anthony, Patel, Vishalkumar, Guo‐Avrutin, Yingying, Pauff, James M., Kazmierczak, Maciej

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