p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells von Ihry, Robert J., Worringer, Kathleen A., Salick, Max R., Frias, Elizabeth, Ho, Daniel, Theriault, Kraig, Kommineni, Sravya, Chen, Julie, Sondey, Marie, Ye, Chaoyang, Randhawa, Ranjit, Kulkarni, Tripti, Yang, Zinger, McAllister, Gregory, Russ, Carsten, Reece-Hoyes, John, Forrester, William, Hoffman, Gregory R., Dolmetsch, Ricardo, Kaykas, Ajamete

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DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks von van Overbeek, Megan, Capurso, Daniel, Carter, Matthew M., Thompson, Matthew S., Frias, Elizabeth, Russ, Carsten, Reece-Hoyes, John S., Nye, Christopher, Gradia, Scott, Vidal, Bastien, Zheng, Jiashun, Hoffman, Gregory R., Fuller, Christopher K., May, Andrew P.

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Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex von Kim, Sang Gyun, Hoffman, Gregory R., Poulogiannis, George, Buel, Gwen R., Jang, Young Jin, Lee, Ki Won, Kim, Bo-Yeon, Erikson, Raymond L., Cantley, Lewis C., Choo, Andrew Y., Blenis, John

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Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy von Eng, Christina H., Wang, Zuncai, Tkach, Diane, Toral-Barza, Lourdes, Ugwonali, Savuth, Liu, Shanming, Fitzgerald, Stephanie L., George, Elizabeth, Frias, Elizabeth, Cochran, Nadire, De Jesus, Rowena, McAllister, Gregory, Hoffman, Gregory R., Bray, Kevin, Lemon, LuAnna, Lucas, Judy, Fantin, Valeria R., Abraham, Robert T., Murphy, Leon O., Nyfeler, Beat

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers von Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

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Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy von Potting, Christoph, Crochemore, Christophe, Moretti, Francesca, Nigsch, Florian, Schmidt, Isabel, Manneville, Carole, Carbone, Walter, Knehr, Judith, DeJesus, Rowena, Lindeman, Alicia, Maher, Rob, Russ, Carsten, McAllister, Gregory, Reece-Hoyes, John S., Hoffman, Gregory R., Roma, Guglielmo, Müller, Matthias, Sailer, Andreas W., Helliwell, Stephen B.

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Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes von Ihry, Robert J., Salick, Max R., Ho, Daniel J., Sondey, Marie, Kommineni, Sravya, Paula, Steven, Raymond, Joe, Henry, Beata, Frias, Elizabeth, Wang, Qiong, Worringer, Kathleen A., Ye, Chaoyang, Russ, Carsten, Reece-Hoyes, John S., Altshuler, Robert C., Randhawa, Ranjit, Yang, Zinger, McAllister, Gregory, Hoffman, Gregory R., Dolmetsch, Ricardo, Kaykas, Ajamete

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Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 von DeJesus, Rowena, Moretti, Francesca, McAllister, Gregory, Wang, Zuncai, Bergman, Phil, Liu, Shanming, Frias, Elizabeth, Alford, John, Reece-Hoyes, John S, Lindeman, Alicia, Kelliher, Jennifer, Russ, Carsten, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, Ng, Aylwin, Tallarico, John A, Porter, Jeffery A, Xavier, Ramnik J, Mickanin, Craig, Murphy, Leon O, Hoffman, Gregory R, Nyfeler, Beat

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Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells von Li, Jing, Csibi, Alfredo, Yang, Sun, Hoffman, Gregory R., Li, Chenggang, Zhang, Erik, Yu, Jane J., Blenis, John

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Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells von Estoppey, David, Hewett, Jeffrey W., Guy, Chantale T., Harrington, Edmund, Thomas, Jason R., Schirle, Markus, Cuttat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Pan, Xuewen, Xie, Kevin, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory R., Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John S., Wang, Qiong, Chen, Xin, McAllister, Gregory, Roma, Guglielmo, Bouwmeester, Tewis, Hoepfner, Dominic

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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons von Sanchez, Carlos G., Acker, Christopher M., Gray, Audrey, Varadarajan, Malini, Song, Cheng, Cochran, Nadire R., Paula, Steven, Lindeman, Alicia, An, Shaojian, McAllister, Gregory, Alford, John, Reece-Hoyes, John, Russ, Carsten, Craig, Lucas, Capre, Ketthsy, Doherty, Christian, Hoffman, Gregory R., Luchansky, Sarah J., Polydoro, Manuela, Dolmetsch, Ricardo, Elwood, Fiona

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening von McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

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YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury von Planas-Paz, Lara, Sun, Tianliang, Pikiolek, Monika, Cochran, Nadire R., Bergling, Sebastian, Orsini, Vanessa, Yang, Zinger, Sigoillot, Frederic, Jetzer, Jasna, Syed, Maryam, Neri, Marilisa, Schuierer, Sven, Morelli, Lapo, Hoppe, Philipp S., Schwarzer, Wibke, Cobos, Carlos M., Alford, John L., Zhang, Le, Cuttat, Rachel, Waldt, Annick, Carballido-Perrig, Nicole, Nigsch, Florian, Kinzel, Bernd, Nicholson, Thomas B., Yang, Yi, Mao, Xiaohong, Terracciano, Luigi M., Russ, Carsten, Reece-Hoyes, John S., Gubser Keller, Caroline, Sailer, Andreas W., Bouwmeester, Tewis, Greenbaum, Linda E., Lugus, Jesse J., Cong, Feng, McAllister, Gregory, Hoffman, Gregory R., Roma, Guglielmo, Tchorz, Jan S.

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Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling von Yu, Yonghao, Yoon, Sang-Oh, Poulogiannis, George, Yang, Qian, Ma, Xiaoju Max, Villén, Judit, Kubica, Neil, Hoffman, Gregory R., Cantley, Lewis C., Gygi, Steven P., Blenis, John

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TMEM41B is a novel regulator of autophagy and lipid mobilization von Moretti, Francesca, Bergman, Phil, Dodgson, Stacie, Marcellin, David, Claerr, Isabelle, Goodwin, Jonathan M, DeJesus, Rowena, Kang, Zhao, Antczak, Christophe, Begue, Damien, Bonenfant, Debora, Graff, Alexandra, Genoud, Christel, Reece‐Hoyes, John S, Russ, Carsten, Yang, Zinger, Hoffman, Gregory R, Mueller, Matthias, Murphy, Leon O, Xavier, Ramnik J, Nyfeler, Beat

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CRISPR/Cas9-Based Chemogenomic Profiling in Mammalian Cells von Hoepfner, Dominic, McAllister, Gregory, Hoffman, Gregory R.

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A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique von Hoffman, Gregory R, Moerke, Nathan J, Hsia, Max, Shamu, Caroline E, Blenis, John

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TRRAP is a central regulator of human multiciliated cell formation von Wang, Zhao, Plasschaert, Lindsey W, Aryal, Shivani, Renaud, Nicole A, Yang, Zinger, Choo-Wing, Rayman, Pessotti, Angelica D, Kirkpatrick, Nathaniel D, Cochran, Nadire R, Carbone, Walter, Maher, Rob, Lindeman, Alicia, Russ, Carsten, Reece-Hoyes, John, McAllister, Gregory, Hoffman, Gregory R, Roma, Guglielmo, Jaffe, Aron B

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Spontaneous Nucleotide Exchange in Low Molecular Weight GTPases by Fluorescently Labeled γ-Phosphate-Linked GTP Analogs von Korlach, Jonas, Baird, Daniel W., Heikal, Ahmed A., Gee, Kyle R., Hoffman, Gregory R., Webb, Watt W.

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Signaling to the Rho GTPases: networking with the DH domain von Hoffman, Gregory R, Cerione, Richard A

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