Targeting Neuroinflammation to Treat Alzheimer’s Disease von Ardura-Fabregat, A., Boddeke, E. W. G. M., Boza-Serrano, A., Brioschi, S., Castro-Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, Michael T., Hoeijmakers, L., Hoffmann, A., Iaccarino, L., Jahnert, S., Kuhbandner, K., Landreth, G., Lonnemann, N., Löschmann, P. A., McManus, R. M., Paulus, A., Reemst, K., Sanchez-Caro, J. M., Tiberi, A., Van der Perren, A., Vautheny, A., Venegas, C., Webers, A., Weydt, P., Wijasa, T. S., Xiang, X., Yang, Y.

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Local administration of immunotherapy for patients with skin cancer: A systematic review von Janssen, J.C., van Dijk, B., Hoeijmakers, L.L., Grünhagen, D.J., Bramer, W.M., Verhoef, C., de Gruijl, T.D., Blank, C.U., van der Veldt, A.A.M.

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Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor von Hartmann, J, Dedic, N, Pöhlmann, M L, Häusl, A, Karst, H, Engelhardt, C, Westerholz, S, Wagner, K V, Labermaier, C, Hoeijmakers, L, Kertokarijo, M, Chen, A, Joëls, M, Deussing, J M, Schmidt, M V

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Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS von Morales-Quinteros, Luis, Serpa Neto, Ary, Artigas, Antonio, Blanch, Lluis, Botta, Michela, Kaufman, David A., Schultz, Marcus J., Tsonas, Anissa M., Paulus, Frederique, Bos, Lieuwe D.

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Biomarker-Driven Personalization of Neoadjuvant Immunotherapy in Melanoma von Hoeijmakers, Lotte L, Reijers, Irene L M, Blank, Christian U

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Nature and management of melanoma recurrences following adjuvant anti-PD-1 based therapy von Woodford, Rachel, McKeown, Janet, Hoeijmakers, Lotte L., Mangana, Johanna, Dimitriou, Florentia, Allayous, Clara, Zaman, Farzana, Aya, Francisco, Marsiglio, John, Goodman, Rachel, Rayson, Victoria, Placzke, Joanna, Kessels, Jolien, Ramalyte, Egle, Haque, Waqas, Wilson, Isabella, Trojaniello, Claudia, Benannoune, Naima, Roberts-Thomson, Rachel, Robert, Caroline, Blank, Christian U., Dummer, Reinhard, Lebbe, Celeste, Haydon, Andrew, Arance, Ana, Hu-Lieskovan, Siwen, Johnson, Douglas B., Mcarthur, Grant A., Rutkowski, Piotr, Neyns, Bart, Sullivan, Ryan J., Weber, Jeffrey, Carlino, Matteo S., Ascierto, Paolo A., Lo, Serigne, Long, Georgina V., Menzies, Alexander M.

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P.3.003 Chronic early-life stress programs hippocampal neurogenesis and cognitive function: a role for epigenetics? von Naninck, E.F.G, Hoeijmakers, L, Engel, M, Lucassen, P.J, Korosi, A

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1121P Interferon-gamma (IFNy) gene signature as a predictive biomarker for response in lactate dehydrogenase (LDH) low advanced melanoma patients von Hoeijmakers, L., Dimitriadis, P., van Vliet, A., Versluis, J.M., Peeper, D., Blank, C.U.

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PND65 FILLING THE GAP IN MS; UNIQUE IDENTIFICATION OF PREVALANCE & TREATMENT OF SPMS PATIENTS IN THE NETHERLANDS von Koenders, J., Van Munster, C.E., Hoeijmakers, L.

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Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts von Sjoding, Michael, Sinha, Pratik, Bhavani, Sivasubramanium V, Lyons, Patrick G, Bewley, Alice F, Botta, Michela, Tsonas, Anissa M, Serpa Neto, Ary, Schultz, Marcus J, Dickson, Robert P, Paulus, Frederique, van Akkeren, J.P., Algera, A.G., Algoe, C.K., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman-van Gemert, A.W.M.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., Martin-Loeches, I., Mazzinari, G., van Meenen, D.M.P., Morales-Quinteros, L., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Serpa Neto, A., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., Vlaar, A.P.J., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H.

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1090P High concurrent interferon gamma signature expression in the primary tumor and lymph node metastasis is associated with superior outcome upon neoadjuvant ipilimumab + nivolum... von Hoeijmakers, L., Dimitriadis, P., Cornelissen, S., Reijers, I., van de Wiel, B., Scolyer, R.A., Saw, R.P.M., Spillane, A.J., Broeks, A., Lopez-Yurda, M., Grijpink-Ongering, L., Hospers, G., Menzies, A.M., van Akkooi, A.C.J., Van Houdt, W., Long, G.V., Blank, C.U.

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Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties von Hartmann, Jakob, Wagner, Klaus V, Gaali, Steffen, Kirschner, Alexander, Kozany, Christian, Rühter, Gerd, Dedic, Nina, Häusl, Alexander S, Hoeijmakers, Lianne, Westerholz, Sören, Namendorf, Christian, Gerlach, Tamara, Uhr, Manfred, Chen, Alon, Deussing, Jan M, Holsboer, Florian, Hausch, Felix, Schmidt, Mathias V

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Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine von Gassen, Nils C, Fries, Gabriel R, Zannas, Anthony S, Hartmann, Jakob, Zschocke, Jürgen, Hafner, Kathrin, Carrillo-Roa, Tania, Steinbacher, Jessica, Preißinger, S Nicole, Hoeijmakers, Lianne, Knop, Matthias, Weber, Frank, Kloiber, Stefan, Lucae, Susanne, Chrousos, George P, Carell, Thomas, Ising, Marcus, Binder, Elisabeth B, Schmidt, Mathias V, Rüegg, Joëlle, Rein, Theo

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1112P Five-year survival after intermittent targeted therapy and anti-PD1 in stage IV melanoma: An update of the IMPemBra trial von Hoeijmakers, L., Rozeman, E.A., Lopez-Yurda, M., Grijpink-Ongering, L., Heeres, B., van de Wiel, B., Flohil, C., Sari, A., Heijmink, S., Van Den Broek, D., Broeks, A., de Groot, J.W., Vollebergh, M., Wilgenhof, S., van Thienen, H.V., Haanen, J.B.A.G., Blank, C.U.

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Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study von Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W., Paulus, Frederique, Schultz, Marcus J., Pisani, Luigi, Algera, A.G., Boers, L.S., Bos, L.D.J., Botta, M., Dongelmans, D.A., Hollmann, M.W., Horn, J., Paulus, F., Pillay, J., Schultz, M.J., Neto, A. Serpa, Tsonas, A.M., Vlaar, A.P.J., Ahuja, S., van Akkeren, J.P., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Bogerd, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O.L., Determann, R.M., Dieperink, W., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hoogendoorn, M.E., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Pennartz, C.J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H.

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Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients - insights from the PRoVENT-COVID study: a national... von Ahuja, Sanchit, de Grooth, Harm-Jan, Paulus, Frederique, van der Ven, Fleur L, Serpa Neto, Ary, Schultz, Marcus J, Tuinman, Pieter R

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Early-life stress affects microglia, possible modulation by dietary fatty acids von Reemst, K., Hoeijmakers, L., Yam, K.Y., Van der Beek, E.M., Schipper, L., Oosting, A., Van Dam, A., Lucassen, P.J., Korosi, A.

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Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study von Schuijt, Michiel T.U., Martin-Loeches, Ignacio, Schultz, Marcus J., Paulus, Frederique, Neto, Ary Serpa, van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Aldridge, M.S. Galek, de Graaff, M.J., Hagens, L.A., Haringman, J.J., Heijnen, N.F.L., Hiel, S., van der Heide, S.T., van der Heiden, P.L.J., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman, A.W.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Martin-Loeches, I., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Neto, A. Serpa, Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen, F.L., Vlaar, A.P.J., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P., van der Wier, H.H., van Welie, L., Wesselink, H.J.F.T., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H.

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Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study von Botta, Michela, Tsonas, Anissa M, Pillay, Janesh, Boers, Leonoor S, Algera, Anna Geke, Bos, Lieuwe D J, Dongelmans, Dave A, Hollmann, Marcus W, Horn, Janneke, Vlaar, Alexander P J, Schultz, Marcus J, Neto, Ary Serpa, Paulus, Frederique, van Akkeren, Jesse P., Algera, Anna Geke, Algoe, Cheetel K., van Amstel, Rombout B., Baur, Onno L., van de Berg, Pablo, van den Berg, Alida E., Bergmans, Dennis C.J.J., van den Bersselaar, Dido I., Bertens, Freke A., Bindels, Alexander J.G.H., de Boer, Milou M., den Boer, Sylvia, Boers, Leonoor S., Bogerd, Margriet, Bos, Lieuwe D.J., Botta, Michela, Breel, Jennifer S., de Bruin, Hendrik, de Bruin, Sanne, Bruna, Caro L., Buiteman-Kruizinga, Laura A., Cremer, Olaf L., Determann, Rogier M., Dieperink, Willem, Dongelmans, Dave A., Franke, Hildegard S., Galek-Aldridge, Michal S., de Graaff, Mart J., Hagens, Laura A., Haringman, Jasper J., van der Heide, Sebastiaan T., van der Heiden, Pim L.J., Heijnen, Nanon F.L., Hiel, Stephan J.P., Hoeijmakers, Lotte L., Hol, Liselotte, Hollmann, Markus W., Hoogendoorn, Marga E., Horn, Janneke, van der Horst, Robrecht, Ie, Evy L.K., Ivanov, Dimitri P., Juffermans, Nicole, Kho, Eline, de Klerk, Eline S., Koopman-van Gemert, Ankie W.M.M., Koopmans, Matty, Kucukcelebi, Songul, Kuiper, Michael A., de Lange, Dylan W., van Mourik, Niels, Nijbroek, Sunny G.L.H., Onrust, Marisa, Oostdijk, Evelien A.N., Paulus, Frederique, Pennartz, Charlotte J., Pillay, Janesh, Pisani, Luigi, Purmer, Ilse M., Rettig, Thijs C.D., Roozeman, Jan-Paul, Schuijt, Michiel T.U., Schultz, Marcus J., Serpa Neto, Ary, Sleeswijk, Mengalvio E., Smit, Marry R., Spronk, Peter E., Stilma, Willemke, Strang, Aart C., Tsonas, Anissa M., Tuinman, Pieter R., Valk, Christel M.A., Veen-Schra, Felicia L., Veldhuis, Lars I., van Velzen, Patricia, van der Ven, Ward H., Vlaar, Alexander P.J., van Vliet, Peter, van der Voort, Peter H.J., van Welie, Louis, Wesselink, Henrico J.F.T., van der Wier-Lubbers, Hermien H., van Wijk, Bas, Winters, Tineke, Wong, Wing Yi, van Zanten, Arthur R.H.

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Prognostication using SpO 2 /FiO 2 in invasively ventilated ICU patients with ARDS due to COVID-19 - Insights from the PRoVENT-COVID study von Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W, Paulus, Frederique, Schultz, Marcus J, Pisani, Luigi

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