CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations von Höijer, Ida, Emmanouilidou, Anastasia, Östlund, Rebecka, van Schendel, Robin, Bozorgpana, Selma, Tijsterman, Marcel, Feuk, Lars, Gyllensten, Ulf, den Hoed, Marcel, Ameur, Adam

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Variability in the heritability of body mass index: a systematic review and meta-regression von Elks, Cathy E, den Hoed, Marcel, Zhao, Jing Hua, Sharp, Stephen J, Wareham, Nicholas J, Loos, Ruth J F, Ong, Ken K

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Heritability of objectively assessed daily physical activity and sedentary behavior von Hoed, Marcel den, Brage, Søren, Zhao, Jing Hua, Westgate, Kate, Nessa, Ayrun, Ekelund, Ulf, Spector, Tim D, Wareham, Nicholas J, Loos, Ruth JF

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Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach von von der Heyde, Benedikt, Emmanouilidou, Anastasia, Mazzaferro, Eugenia, Vicenzi, Silvia, Höijer, Ida, Klingström, Tiffany, Jumaa, Sitaf, Dethlefsen, Olga, Snieder, Harold, de Geus, Eco, Ameur, Adam, Ingelsson, Erik, Allalou, Amin, Brooke, Hannah L., den Hoed, Marcel

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Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis von Richmond, Rebecca C, Davey Smith, George, Ness, Andy R, den Hoed, Marcel, McMahon, George, Timpson, Nicholas J

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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention von Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Bentley, Amy R., Chong, Mike, Berry, Diane, Feenstra, Bjarke, Feitosa, Mary F., Hall, Leanne M., Huikari, Ville, Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Monroe, Kristine R., Richmond, Rebecca C., Rivera, Natalia V., Turman, Constance, van Rooij, Frank J. A., Zhao, Jing-Hua, Zhao, Wei, Baumeister, Sebastian E., Brage, Soren, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Franco, Oscar H., Galesloot, Tessel E., Grarup, Niels, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Li, Aihua, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Pedersen, Nancy L., Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Ridker, Paul M., Rudan, Igor, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Siggeirsdottir, Kristin, Teo, Koon K., Thorand, Barbara, Xu, Huichun, Young, Kristin L., Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bouchard, Claude, Chasman, Daniel I., Deldicque, Louise, Fornage, Myriam, Gudnason, Vilmundur, Gyllensten, Ulf, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Kardia, Sharon L. R., Kiemeney, Lambertus A., Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Pers, Tune H., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Spector, Tim D., van Dam, Rob M., van der Velde, Nathalie, Vollenweider, Peter, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Wichmann, Heinz-Erich, Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I.

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Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity von Höijer, Ida, Johansson, Josefin, Gudmundsson, Sanna, Chin, Chen-Shan, Bunikis, Ignas, Häggqvist, Susana, Emmanouilidou, Anastasia, Wilbe, Maria, den Hoed, Marcel, Bondeson, Marie-Louise, Feuk, Lars, Gyllensten, Ulf, Ameur, Adam

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Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence: Influence of Loci Identified by Genome-Wide Association Studies von DEN HOED, Marcel, EKELUND, Ulf, BRAGE, Søren, GRONTVED, Anders, JING HUA ZHAO, SHARP, Stephen J, ONG, Ken K, WAREHAM, Nicholas J, LOOS, Ruth J. F

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Distilling causality between physical activity traits and obesity via Mendelian randomization von Wang, Zhe, Davey Smith, George, Loos, Ruth J. F., den Hoed, Marcel

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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification von Lagou, Vasiliki, Jiang, Longda, Ulrich, Anna, Zudina, Liudmila, González, Karla Sofia Gutiérrez, Balkhiyarova, Zhanna, Faggian, Alessia, Maina, Jared G., Chen, Shiqian, Todorov, Petar V., Sharapov, Sodbo, David, Alessia, Marullo, Letizia, Mägi, Reedik, Rujan, Roxana-Maria, Ahlqvist, Emma, Thorleifsson, Gudmar, Gao, Ηe, Εvangelou, Εvangelos, Benyamin, Beben, Scott, Robert A., Isaacs, Aaron, Zhao, Jing Hua, Willems, Sara M., Johnson, Toby, Gieger, Christian, Grallert, Harald, Meisinger, Christa, Müller-Nurasyid, Martina, Strawbridge, Rona J., Goel, Anuj, Rybin, Denis, Albrecht, Eva, Jackson, Anne U., Stringham, Heather M., Corrêa, Ivan R., Farber-Eger, Eric, Steinthorsdottir, Valgerdur, Uitterlinden, André G., Munroe, Patricia B., Brown, Morris J., Schmidberger, Julian, Holmen, Oddgeir, Thorand, Barbara, Hveem, Kristian, Wilsgaard, Tom, Mohlke, Karen L., Wang, Zhe, Shmeliov, Aleksey, den Hoed, Marcel, Loos, Ruth J. F., Kratzer, Wolfgang, Haenle, Mark, Koenig, Wolfgang, Boehm, Bernhard O., Tan, Tricia M., Tomas, Alejandra, Salem, Victoria, Barroso, Inês, Tuomilehto, Jaakko, Boehnke, Michael, Florez, Jose C., Hamsten, Anders, Watkins, Hugh, Njølstad, Inger, Wichmann, H.-Erich, Caulfield, Mark J., Khaw, Kay-Tee, van Duijn, Cornelia M., Hofman, Albert, Wareham, Nicholas J., Langenberg, Claudia, Whitfield, John B., Martin, Nicholas G., Montgomery, Grant, Scapoli, Chiara, Tzoulaki, Ioanna, Elliott, Paul, Thorsteinsdottir, Unnur, Stefansson, Kari, Brittain, Evan L., McCarthy, Mark I., Froguel, Philippe, Sexton, Patrick M., Wootten, Denise, Groop, Leif, Dupuis, Josée, Meigs, James B., Deganutti, Giuseppe, Demirkan, Ayse, Pers, Tune H., Reynolds, Christopher A., Aulchenko, Yurii S., Kaakinen, Marika A., Jones, Ben, Prokopenko, Inga

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Investigating the role of lipid genes in liver disease using models of steatotic liver disease in zebrafish ( Danio rerio ) von Mujica, Endrina, den Hoed, Marcel

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Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomis... von Strawbridge, Rona J., Silveira, Angela, Hoed, Marcel den, Gustafsson, Stefan, Luan, Jian'an, Rybin, Denis, Dupuis, Josée, Li-Gao, Ruifang, Kavousi, Maryam, Dehghan, Abbas, Haljas, Kadri, Lahti, Jari, Gådin, Jesper R., Bäcklund, Alexandra, de Faire, Ulf, Gertow, Karl, Giral, Phillipe, Goel, Anuj, Humphries, Steve E., Kurl, Sudhir, Langenberg, Claudia, Lannfelt, Lars L., Lind, Lars, Lindgren, Cecilia C.M., Mannarino, Elmo, Mook-Kanamori, Dennis O., Morris, Andrew P., de Mutsert, Renée, Rauramaa, Rainer, Saliba-Gustafsson, Peter, Sennblad, Bengt, Smit, Andries J., Syvänen, Ann-Christine, Tremoli, Elena, Veglia, Fabrizio, Zethelius, Björn, Björck, Hanna M., Eriksson, Johan G., Hofman, Albert, Franco, Oscar H., Watkins, Hugh, Jukema, J. Wouter, Florez, Jose C., Wareham, Nicholas J., Meigs, James B., Ingelsson, Erik, Baldassarre, Damiano, Hamsten, Anders

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Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance von Soenen, Stijn, Mariman, Edwin C.M, Vogels, Neeltje, Bouwman, Freek G, den Hoed, Marcel, Brown, Louise, Westerterp-Plantenga, Margriet S

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Abstract 437: Large-scale Validation of Zebrafish Larvae as a Model System for Systematic Genetic Screens in Dyslipidemia, Atherosclerosis and Coronary Artery Disease von Bandaru, Manoj, den Hoed, Marcel

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Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity von den Hoed, Marcel, Hesselink, Matthijs K. C, van Kranenburg, Gerrit P. J, Westerterp, Klaas R

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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes von Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig, Anderson, Christopher D., Almgren, Peter, Amouyel, Philippe, Bartz, Traci M., Benavente, Oscar R., Boncoraglio, Giorgio B., Butterworth, Adam S., Carrera, Caty, Chasman, Daniel I., Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul I. W., Duan, Qing, Gottesman, Rebecca F., Harris, Tamara B., Hassan, Ahamad, Havulinna, Aki S., Heckbert, Susan R., Hyacinth, Hyacinth I., Ikram, M. Arfan, Ingelsson, Erik, Jian, Xueqiu, Jukema, J. Wouter, Kanai, Masahiro, Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Kooperberg, Charles, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Lemmens, Robin, Lewis, Cathryn M., Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K., Meschia, James F., Mitchell, Braxton D., Mosley, Thomas H., Nalls, Michael A., O’Donnell, Martin J., Pulit, Sara L., Reiner, Alexander P., Ridker, Paul M., Rothwell, Peter M., Rotter, Jerome I., Sale, Michele M., Salomaa, Veikko, Sapkota, Bishwa R., Schmidt, Reinhold, Schmidt, Carsten O., Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L. M., Tanislav, Christian, Thijs, Vincent N. S., Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Wilson, James G., Pastinen, Tomi, Ruusalepp, Arno, Koplev, Simon, Björkegren, Johan L. M., Codoni, Veronica, Civelek, Mete, Christophersen, Ingrid E., Roselli, Carolina, Ellinor, Patrick T., Kato, Norihiro, van der Harst, Pim, Elliott, Paul, Takeuchi, Fumihiko, Johnson, Andrew D., Sanghera, Dharambir K., Melander, Olle, Strbian, Daniel, Fernandez-Cadenas, Israel, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Pare, Guillaume, Hopewell, Jemma C., Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B., Seshadri, Sudha, Markus, Hugh S., Debette, Stephanie, Dichgans, Martin

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WED-454 - Zebrafish larvae as a model system to characterize effects of metabolic, drug and genetic perturbations on liver fat accumulation von Mujica, Endrina, Zhang, Hanqing, Emmanouilidou, Anastasia, Allalou, Amin, den Hoed, Marcel

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Zebrafish larvae as a model system to characterize effects of metabolic, drug and genetic perturbations on liver fat accumulation von Mujica, Endrina, Zhang, Hanqing, Emmanouilidou, Anastasia, Allalou, Amin, den Hoed, Marcel

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Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence von den Hoed, Marcel, Ekelund, Ulf, Brage, Søren, Grontved, Anders, Zhao, Jing Hua, Sharp, Stephen J., Ong, Ken K., Wareham, Nicholas J., Loos, Ruth J.F.

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Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC von LIGHTFOOT, J TIMOTHY, DE GEUS, ECO J C, BOOTH, FRANK W, BRAY, MOLLY S, DEN HOED, MARCEL, KAPRIO, JAAKKO, KELLY, SCOTT A, POMP, DANIEL, SAUL, MICHAEL C, THOMIS, MARTINE A, GARLAND, THEODORE, BOUCHARD, CLAUDE

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