Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy von Charych, Deborah, Khalili, Samira, Dixit, Vidula, Kirk, Peter, Chang, Thomas, Langowski, John, Rubas, Werner, Doberstein, Stephen K, Eldon, Michael, Hoch, Ute, Zalevsky, Jonathan

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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy von Sharma, Meenu, Khong, Hiep, Fa’ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

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Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma von Diab, Adi, Tykodi, Scott S., Daniels, Gregory A., Maio, Michele, Curti, Brendan D., Lewis, Karl D., Jang, Sekwon, Kalinka, Ewa, Puzanov, Igor, Spira, Alexander, Cho, Daniel C., Guan, Shanhong, Puente, Erika, Tuan Nguyen, Hoch, Ute, Currie, Sue L., Lin, Wei, Tagliaferri, Mary A., Zalevsky, Jonathan, Sznol, Mario, Hurwitz, Michael E.

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Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma von TONG, Wei-Gang, RONG CHEN, MAHADOCON, Kristi, TIANLING CHEN, KEGLEY, Peggy, HOCH, Ute, WIERDA, William G, PLUNKETT, William, SIEGEL, David, SINHA, Rajni, HARVEY, R. Donald, BADROS, Ashraf Z, POPPLEWELL, Leslie, COUTRE, Steven, FOX, Judith A

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Change in Topoisomerase 1-Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol von Rugo, Hope S, Cortes, Javier, Awada, Ahmad, O'Shaughnessy, Joyce, Twelves, Chris, Im, Seock-Ah, Hannah, Alison, Lu, Lin, Sy, Sherwin, Caygill, Katie, Zajchowski, Deborah A, Davis, Darren W, Tagliaferri, Mary, Hoch, Ute, Perez, Edith A

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Etirinotecan pegol (NKTR-102) versus treatment of physician's choice in women with advanced breast cancer previously treated with an anthracycline, a taxane, and capecitabine (BEAC... von Perez, Edith A, Dr, Awada, Ahmad, MD, O'Shaughnessy, Joyce, MD, Rugo, Hope S, MD, Twelves, Chris, MD, Im, Seock-Ah, MD, Gómez-Pardo, Patricia, MD, Schwartzberg, Lee S, MD, Diéras, Veronique, MD, Yardley, Denise A, MD, Potter, David A, MD, Mailliez, Audrey, MD, Moreno-Aspitia, Alvaro, MD, Ahn, Jin-Seok, MD, Zhao, Carol, MS, Hoch, Ute, PhD, Tagliaferri, Mary, MD, Hannah, Alison L, MD, Cortes, Javier, MD

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Two schedules of etirinotecan pegol (NKTR-102) in patients with previously treated metastatic breast cancer: a randomised phase 2 study von Awada, Ahmad, Dr Prof, Garcia, Agustin A, MD, Chan, Stephen, MD, Jerusalem, Guy H M, Prof, Coleman, Robert E, Prof, Huizing, Manon T, Prof, Mehdi, Aminder, MD, O'Reilly, Sue M, MD, Hamm, John T, MD, Barrett-Lee, Peter J, Prof, Cocquyt, Veronique, Prof, Sideras, Kostandinos, MD, Young, David E, MD, Zhao, Carol, MS, Chia, Yen Lin, PhD, Hoch, Ute, PhD, Hannah, Alison L, MD, Perez, Edith A, Prof

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NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer von Walker, Joshua M, Rolig, Annah S, Charych, Deborah H, Hoch, Ute, Kasiewicz, Melissa J, Rose, Daniel C, McNamara, Michael J, Hilgart-Martiszus, Ian F, Redmond, William L

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Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study von Tannir, Nizar M, Cho, Daniel C, Diab, Adi, Sznol, Mario, Bilen, Mehmet A, Balar, Arjun V, Grignani, Giovanni, Puente, Erika, Tang, Lily, Chien, David, Hoch, Ute, Choudhury, Arkopal, Yu, Danni, Currie, Sue L, Tagliaferri, Mary A, Zalevsky, Jonathan, Siefker-Radtke, Arlene O, Hurwitz, Michael E

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Discovery of a potent and selective Aurora kinase inhibitor von Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

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Voreloxin, a First-in-Class Anticancer Quinolone Derivative, in Relapsed/Refractory Solid Tumors: A Report on Two Dosing Schedules von ADVANI, Ranjana H, HURWITZ, Herbert I, FOX, Judith A, ALLEN, Roberta S, ADELMAN, Daniel C, GORDON, Michael S, EBBINGHAUS, Scot W, MENDELSON, David S, WAKELEE, Heather A, HOCH, Ute, SILVERMAN, Jeffrey A, HAVRILLA, Nancy A, BERMAN, Craig J

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EpoK, a Cytochrome P450 Involved in Biosynthesis of the Anticancer Agents Epothilones A and B. Substrate-Mediated Rescue of a P450 Enzyme von Ogura, Hiroshi, Nishida, Clinton R, Hoch, Ute R, Perera, Roshan, Dawson, John H, Ortiz de Montellano, Paul R

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Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Repl... von EVANCHIK, Marc J, ALLEN, Darin, YOBURN, Josh C, SILVERMAN, Jeffrey A, HOCH, Ute

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420 Progression-free survival and biomarker correlates of response with BEMPEG plus NIVO in previously untreated patients with metastatic melanoma: results from the PIVOT-02 study... von Diab, Adi, Tykodi, Scott, Daniels, Gregory, Maio, Michele, Curti, Brendan, Lewis, Karl, Jang, Sekwon, Kalinka, Ewa, Puzanov, Igor, Spira, Alexander, Cho, Daniel, Guan, Shanhong, Puente, Erika, Hoch, Ute, Currie, Sue, Nguyen, Tuan, Lin, Wei, Tagliaferri, Mary, Zalevsky, Jonathan, Sznol, Mario, Hurwitz, Michael

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A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors von Bentebibel, Salah-Eddine, Hurwitz, Michael E, Bernatchez, Chantale, Haymaker, Cara, Hudgens, Courtney W, Kluger, Harriet M, Tetzlaff, Michael T, Tagliaferri, Mary A, Zalevsky, Jonathan, Hoch, Ute, Fanton, Christie, Aung, Sandra, Hwu, Patrick, Curti, Brendan D, Tannir, Nizar M, Sznol, Mario, Diab, Adi

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Covalently Linked Heme in Cytochrome P4504A Fatty Acid Hydroxylases von Hoch, Ute, Ortiz de Montellano, Paul R.

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Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02) von Diab, Adi, Tannir, Nizar M., Bentebibel, Salah-Eddine, Hwu, Patrick, Papadimitrakopoulou, Vassiliki, Haymaker, Cara, Kluger, Harriet M., Gettinger, Scott N., Sznol, Mario, Tykodi, Scott S., Curti, Brendan D., Tagliaferri, Mary A., Zalevsky, Jonathan, Hannah, Alison L., Hoch, Ute, Aung, Sandra, Fanton, Christie, Rizwan, Ahsan, Iacucci, Ernesto, Liao, Yijie, Bernatchez, Chantale, Hurwitz, Michael E., Cho, Daniel C.

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Pharmacokinetics in Animals and Humans of a First-in-Class Peptide Deformylase Inhibitor von RAMANATHAN-GIRISH, Sandhya, MCCOLM, Juliet, GADD, Alison, HOCH, Ute, JIANG, Vernon, LOFLAND, Denene, JOHNSON, Kirk W, CLEMENTS, John M, TAUPIN, Phil, BARROWCLILFE, Sue, HEVIZI, John, SAFRIN, Sharon, MOORE, Clive, PATOU, Gary, MOSER, Heinz

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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models von Charych, Deborah H, Hoch, Ute, Langowski, John L, Lee, Steve R, Addepalli, Murali K, Kirk, Peter B, Sheng, Dawei, Liu, Xiaofeng, Sims, Paul W, VanderVeen, Laurie A, Ali, Cherie F, Chang, Thomas K, Konakova, Marina, Pena, Rhoneil L, Kanhere, Rupesh S, Kirksey, Yolanda M, Ji, Chunmei, Wang, Yujun, Huang, Jicai, Sweeney, Theresa D, Kantak, Seema S, Doberstein, Stephen K

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Autocatalytic Mechanism and Consequences of Covalent Heme Attachment in the Cytochrome P4504A Family von LeBrun, Laurie A., Hoch, Ute, Ortiz de Montellano, Paul R.

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