Structural basis for telmisartan-mediated partial activation of PPAR gamma von Amano, Yasushi, Yamaguchi, Tomohiko, Ohno, Kazuki, Niimi, Tatsuya, Orita, Masaya, Sakashita, Hitoshi, Takeuchi, Makoto

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NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes von Tani, Osamu, Akutsu, Yukie, Ito, Shinji, Suzuki, Takayuki, Tateishi, Yukihiro, Yamaguchi, Tomohiko, Niimi, Tatsuya, Namatame, Ichiji, Chiba, Yasunori, Sakashita, Hitoshi, Kubota, Tomomi, Yanagi, Tetsuo, Mizukami, Shusaku, Hirayama, Kenji, Furukawa, Koji, Yamasaki, Kazuhiko

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Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase von Sakamoto, Yasumitsu, Suzuki, Yoshiyuki, Nakamura, Akihiro, Watanabe, Yurie, Sekiya, Mizuki, Roppongi, Saori, Kushibiki, Chisato, Iizuka, Ippei, Tani, Osamu, Sakashita, Hitoshi, Inaka, Koji, Tanaka, Hiroaki, Yamada, Mitsugu, Ohta, Kazunori, Honma, Nobuyuki, Shida, Yosuke, Ogasawara, Wataru, Nakanishi-Matsui, Mayumi, Nonaka, Takamasa, Gouda, Hiroaki, Tanaka, Nobutada

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Correction to NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes von Tani, Osamu, Akutsu, Yukie, Ito, Shinji, Suzuki, Takayuki, Tateishi, Yukihiro, Yamaguchi, Tomohiko, Niimi, Tatsuya, Namatame, Ichiji, Chiba, Yasunori, Sakashita, Hitoshi, Kubota, Tomomi, Yanagi, Tetsuo, Mizukami, Shusaku, Hirayama, Kenji, Furukawa, Koji, Yamasaki, Kazuhiko

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Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei von Kubota, Tomomi, Tani, Osamu, Yamaguchi, Tomohiko, Namatame, Ichiji, Sakashita, Hitoshi, Furukawa, Koji, Yamasaki, Kazuhiko

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Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor von Ohno, Kazuki, Amano, Yasushi, Kakuta, Hirotoshi, Niimi, Tatsuya, Takakura, Shoji, Orita, Masaya, Miyata, Keiji, Sakashita, Hitoshi, Takeuchi, Makoto, Komuro, Issei, Higaki, Jitsuo, Horiuchi, Masatsugu, Kim-Mitsuyama, Shokei, Mori, Yutaka, Morishita, Ryuichi, Yamagishi, Sho-ichi

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Points to consider in establishment of cell substrate used for manufacture of biotechnological products von KISHIOKA, Yasuhiro, TADA, Minoru, KURIBAYASHI, Ryosuke, HORIUCHI, Takayuki, TAKAKURA, Tomoaki, YAMANO-ADACHI, Noriko, MISAKI, Ryou, ISHII, Jun, OTA, Yasumasa, OHYA, Tomoshi, KATAYAMA, Kazuhiko, KAWAHARA, Akihito, KOYAMA, Shingo, SAKASHITA, Hitoshi, TAKIMURA, Yasushi, MORIMOTO, Takuya, NAKANO, Ayuki, HAYAMIZU, Kenji, HYUGA, Masashi, MURAKAMI, Sei, UCHIDA, Kazuhisa, OMASA, Takeshi, AKIKO-ISHII-WATABE

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Structures of complexes of type 5 17β-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding von Amano, Yasushi, Yamaguchi, Tomohiko, Niimi, Tatsuya, Sakashita, Hitoshi

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Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase von Amano, Yasushi, Namatame, Ichiji, Tateishi, Yukihiro, Honboh, Kazuya, Tanabe, Eiki, Niimi, Tatsuya, Sakashita, Hitoshi

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An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi von Yamasaki, Kazuhiko, Tani, Osamu, Tateishi, Yukihiro, Tanabe, Eiki, Namatame, Ichiji, Niimi, Tatsuya, Furukawa, Koji, Sakashita, Hitoshi

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4‑Hydroxypyridazin-3(2H)‑one Derivatives as Novel d‑Amino Acid Oxidase Inhibitors von Hondo, Takeshi, Warizaya, Masaichi, Niimi, Tatsuya, Namatame, Ichiji, Yamaguchi, Tomohiko, Nakanishi, Keita, Hamajima, Toshihiro, Harada, Katsuya, Sakashita, Hitoshi, Matsumoto, Yuzo, Orita, Masaya, Takeuchi, Makoto

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Design and Synthesis of Non-peptidic Inhibitors for the Syk C-Terminal SH2 Domain Based on Structure-Based In-Silico Screening von Niimi, Tatsuya, Orita, Masaya, Okazawa-Igarashi, Miwa, Sakashita, Hitoshi, Kikuchi, Kazumi, Ball, Evelyn, Ichikawa, Atsushi, Yamagiwa, Yoko, Sakamoto, Shuichi, Tanaka, Akihiro, Tsukamoto, Shinichi, Fujita, Shigeo, Tatsuta, Kuniaki, Maeda, Yasuhide, Chikauchi, Ken

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Structures of complexes of type 5 17[beta]-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding von Amano, Yasushi, Yamaguchi, Tomohiko, Niimi, Tatsuya, Sakashita, Hitoshi

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Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors von Katayama, Naoko, Orita, Masaya, Yamaguchi, Tomohiko, Hisamichi, Hiroyuki, Kuromitsu, Sadao, Kurihara, Hiroyuki, Sakashita, Hitoshi, Matsumoto, Yuzo, Fujita, Shigeo, Niimi, Tatsuya

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Coumarin and Chromen-4-one Analogues as Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor: Discovery and X-ray Crystallography von Orita, Masaya, Yamamoto, Satoshi, Katayama, Naoko, Aoki, Motonori, Takayama, Kazuhisa, Yamagiwa, Yoko, Seki, Norio, Suzuki, Hiroshi, Kurihara, Hiroyuki, Sakashita, Hitoshi, Takeuchi, Makoto, Fujita, Shigeo, Yamada, Toshimitsu, Tanaka, Akihiro

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AR-NE3A, a New Macromolecular Crystallography Beamline for Pharmaceutical Applications at the Photon Factory von Yamada, Yusuke, Hiraki, Masahiko, Sasajima, Kumiko, Matsugaki, Naohiro, Igarashi, Noriyuki, Kikuchi, Takashi, Mori, Takeharu, Toyoshima, Akio, Kishimoto, Shunji, Wakatsuki, Soichi, Amano, Yasushi, Warizaya, Masaichi, Sakashita, Hitoshi

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Peptide Based Interleukin-1.BETA. Converting Enzyme(ICE) Inhibitors: Synthesis, Structure Activity Relationships and Crystallographic Study of the ICE-inhibitor Complex von OKAMOTO, Yoshinori, ANAN, Hideki, NAKAI, Eiichi, MORIHIRA, Koichiro, YONETOKU, Yasuhiro, KURIHARA, Hiroyuki, SAKASHITA, Hitoshi, TERAI, Yoshiya, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo

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Sequence-Specific DNA Recognition of the Escherichia coli Ada Protein Associated with the Methylation-Dependent Functional Switch for Transcriptional Regulation von Sakashita, Hitoshi, Sakuma, Takahiko, Akitomo, Yoshiko, Ohkubo, Tadayasu, Kainosho, Masatsune, Sekiguchi, Mutsuo, Morikawa, Kosuke

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バイオ医薬品製造に用いる細胞基材の樹立に関する留意事項 von 岸岡, 康博, 多田, 稔, 栗林, 亮佑, 堀内, 貴之, 高倉, 知朗, 山野-足立, 範子, 三﨑, 亮, 石井, 純, 太田, 康勝, 大屋, 智資, 片山, 和彦, 川原, 彰人, 小山, 伸吾, 阪下, 日登志, 瀧村, 靖, 森本, 拓也, 中野, 歩希, 早水, 健二, 日向, 昌司, 村上, 聖, 内田, 和久, 大政, 健史, 石井, 明子

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Kinetic Properties and Structural Characterization of Highly Purified Acetyl-CoA Synthetase from Bovine Heart and Tissue Distribution of the Enzyme in Rat Tissues von ISHIKAWA, MOMOYO, FUJINO, TAKAHIRO, SAKASHITA, HITOSHI, MORIKAWA, KOSUKE, YAMAMOTO, TOKUO

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