Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the bench... von Nakayama-Kitamura, Kimiko, Shigemoto-Mogami, Yukari, Toyoda, Hiroko, Mihara, Ikue, Moriguchi, Hiroyuki, Naraoka, Hitoshi, Furihata, Tomomi, Ishida, Seiichi, Sato, Kaoru

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Pharma challenges to adoption of microphysiological system in drug research and development, especially safety assessment von Naraoka, Hitoshi

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Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model von Kuroda, Hiroyuki, Kinomoto, Toshiko, Ogawa, Shuji, Kawabe, Mayumi, Suguro, Mayuko, Naraoka, Hitoshi, Takamatsu, Kazuhiko, Oishi, Yuji

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Metabolic Profiling to Identify Potential Serum Biomarkers for Gastric Ulceration Induced by Nonsteroid Anti-Inflammatory Drugs von Takeuchi, Kenichiro, Ohishi, Maki, Ota, Sana, Suzumura, Kenichi, Naraoka, Hitoshi, Ohata, Takeji, Seki, Jiro, Miyamae, Youichi, Honma, Masashi, Soga, Tomoyoshi

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Cardiotoxicity evaluation using three-dimensional cardiac tissues consisting of human iPS cell-derived cardiomyocytes and fibroblasts by cell coating technique von Tadano, Kiyoshi, Kazusa, Katsuyuki, Takamatsu, Kazuhiko, Naraoka, Hitoshi, Takeda, Maki, Akashi, Mitsuru, Miyagawa, Shigeru, Sawa, Yoshiki

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Metabolomic analysis of the effects of omeprazole and famotidine on aspirin-induced gastric injury von Takeuchi, Kenichiro, Ohishi, Maki, Endo, Keiko, Suzumura, Kenichi, Naraoka, Hitoshi, Ohata, Takeji, Seki, Jiro, Miyamae, Yoichi, Honma, Masashi, Soga, Tomoyoshi

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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin von Takeuchi, Kenichiro, Ohishi, Maki, Endo, Keiko, Suzumura, Kenichi, Naraoka, Hitoshi, Ohata, Takeji, Seki, Jiro, Miyamae, Yoichi, Honma, Masashi, Soga, Tomoyoshi

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A study on the influence of acotiamide hydrochloride hydrate on sex hormones, using a uterotrophic bioassay in rat von Kuroda, Hiroyuki, Yamaguchi, Takashi, Kinomoto, Toshiko, Ogawa, Shuji, Naraoka, Hitoshi, Takamatsu, Kazuhiko, Oishi, Yuji

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Opportunities for microphysiological systems from the view of Japanese industries von Naraoka, Hitoshi, Iguchi, Takuma, Harada, Kosuke, Usui, Toru, Suwa, Yoshiaki, Ando, Masamitsu, Sakura, Takeshi, Ohkubo, Tomoki

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The concern for uterine carcinogenesis in safety assessments for a new pharmaceutical von Kuroda, Hiroyuki, Yamaguchi, Takashi, Kinomoto, Toshiko, Ogawa, Shuji, Shiga, Atsushi, Naraoka, Hitoshi, Takamatsu, Kazuhiko, Oishi, Yuji

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Evaluation of H-FABP as a marker of ongoing myocardial damage using hGH transgenic mice von Naraoka, Hitoshi, Ito, Kyoko, Suzuki, Michie, Naito, Kunihiko, Tojo, Hideaki

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Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice von NARAOKA, Hitoshi, ITO, Kyoko, SUZUKI, Michie, NAITO, Kunihiko, TOJO, Hideaki

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Investigation of Mechanisms for MK-801-Induced Neurotoxicity Utilizing Metabolomic Approach von Kuroda, Kanae, Suzumura, Kenichi, Shirakawa, Takafumi, Hiraishi, Tomoko, Nakahara, Yutaka, Fushiki, Hiroshi, Honda, Sokichi, Naraoka, Hitoshi, Miyoshi, Sosuke, Aoki, Yoshinobu

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Consideration for the validation of clinical laboratory methods in nonclinical fields von Minomo, Hirofumi, Inoue, Yoshimi, Iwachido, Takako, Oota, Hiromi, Otabe, Koji, Kubono, Katsuo, Kondo, Satoshi, Sasaki, Daisuke, Suzuki, Yusuke, Nakamura, Yuta, Naraoka, Hitoshi, Higashiyama, Masumi, Fujisawa, Nozomi, Honda, Kumi, Matsumoto, Tadao, Yasui, Hideki, Saito, Yoshiro, Toyota, Naoto

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医薬品研究開発におけるMicrophysiological systems（MPS）研究の現状―安全性評価を中心に von 奈良岡, 準

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[18F]FDG-PET as an imaging biomarker to NMDA receptor antagonist-induced neurotoxicity von Shirakawa, Takafumi, Mitsuoka, Keisuke, Kuroda, Kanae, Miyoshi, Sosuke, Shiraki, Katsuhisa, Naraoka, Hitoshi, Noda, Akihiro, Fujikawa, Akihiko, Fujiwara, Michio

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S6-3. MPS development based on End-user's Needs von Hitoshi Naraoka

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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin von Kenichiro Takeuchi, Maki Ohishi, Keiko Endo, Kenichi Suzumura, Hitoshi Naraoka, Takeji Ohata, Jiro Seki, Yoichi Miyamae, Masashi Honma, Tomoyoshi Soga

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WS1-6 Investigation of Toxicological Biomarker Discovery by Imaging Mass Spectolometry von Hitoshi NARAOKA, Ken-ichi SUZUMURA, Kenji NAKANO, Yutaka AOKI, Taka-aki SATO, Kouji WATANABE

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P-71. Cardiotoxicity and drug response evaluation using LbL-3D Heart composed of human iPS cell-derived cardiomyocyte von Kiyoshi Tadano, Katsuyuki Kazusa, Kazuhiko Takamatsu, Hitoshi Naraoka, Maki Takeda, Shigeru Miyagawa, Yoshiki Sawa, Yoshinari Tsukamoto, Takami Akagi, Mitsuru Akashi

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