Generation of conditional oncogenic chromosomal translocations using CRISPR–Cas9 genomic editing and homology‐directed repair von Spraggon, Lee, Martelotto, Luciano G, Hmeljak, Julija, Hitchman, Tyler D, Wang, Jiang, Wang, Lu, Slotkin, Emily K, Fan, Pang‐Dian, Reis‐Filho, Jorge S, Ladanyi, Marc

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma von Moore, Amanda R., Ran, Leili, Guan, Youxin, Sher, Jessica J., Hitchman, Tyler D., Zhang, Jenny Q., Hwang, Catalina, Walzak, Edward G., Shoushtari, Alexander N., Monette, Sébastien, Murali, Rajmohan, Wiesner, Thomas, Griewank, Klaus G., Chi, Ping, Chen, Yu

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Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling von Ceraudo, Emilie, Horioka, Mizuho, Mattheisen, Jordan M., Hitchman, Tyler D., Moore, Amanda R., Kazmi, Manija A., Chi, Ping, Chen, Yu, Sakmar, Thomas P., Huber, Thomas

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Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma von Hitchman, Tyler D, Bayshtok, Gabriella, Ceraudo, Emilie, Moore, Amanda R, Lee, Cindy, Jia, Ruobing, Wang, Naitao, Pachai, Mohini R, Shoushtari, Alexander N, Francis, Jasmine H, Guan, Youxin, Chen, Juliet, Chang, Matthew T, Taylor, Barry S, Sakmar, Thomas P, Huber, Thomas, Chi, Ping, Chen, Yu

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma von Moore, Amanda R., Ran, Leili, Guan, Youxin, Sher, Jessica J., Hitchman, Tyler D., Zhang, Jenny Q., Hwang, Catalina, Walczak, Edward G., Shoushtari, Alexander N., Monette, Sébastien, Murali, Rajmohan, Wiesner, Thomas, Griewank, Klaus G., Chi, Ping, Chen, Yu

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Combined Inhibition of G alpha(q) and MEK Enhances Therapeutic Efficacy in Uveal Melanoma von Hitchman, Tyler D., Bayshtok, Gabriella, Ceraudo, Emilie, Moore, Amanda R., Lee, Cindy, Jia, Ruobing, Wang, Naitao, Pachai, Mohini R., Shoushtari, Alexander N., Francis, Jasmine H., Guan, Youxin, Chen, Juliet, Chang, Matthew T., Taylor, Barry S., Sakmar, Thomas P., Huber, Thomas, Chi, Ping, Chen, Yu

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Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition von Hitchman, Tyler D., Ceraudo, Emilie, Moore, Amanda R., Shoushtari, Alexander N., Francis, Jasmine H., Guan, Youxin, Chen, Juliet, Chang, Matthew T., Taylor, Barry S., Sakmar, Thomas P., Huber, Thomas, Chi, Ping, Chen, Yu

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