The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells von Harris, William J., Huang, Xu, Lynch, James T., Spencer, Gary J., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Miller, Crispin J., Ogilvie, Donald J., Somervaille, Tim C.P.

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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia von Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

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ERK5 is a critical mediator of inflammation-driven cancer von Finegan, Katherine G, Perez-Madrigal, Diana, Hitchin, James R, Davies, Clare C, Jordan, Allan M, Tournier, Cathy

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J

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Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells von Atkin, Jane, Halova, Lenka, Ferguson, Jennifer, Hitchin, James R, Lichawska-Cieslar, Agata, Jordan, Allan M, Pines, Jonathon, Wellbrock, Claudia, Petersen, Janni

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Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II von Raoof, Ali, Depledge, Paul, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hopkins, Gemma V, Jordan, Allan M, Maguire, Laura A, McGonagle, Alison E, Mould, Daniel P, Rushbrooke, Mathew, Small, Helen F, Smith, Kate M, Thomson, Graeme J, Turlais, Fabrice, Waddell, Ian D, Waszkowycz, Bohdan, Watson, Amanda J, Ogilvie, Donald J

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NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24 von Torres, Felix, Walser, Reto, Kaderli, Janina, Rossi, Emanuele, Bobby, Romel, Packer, Martin J, Sarda, Sunil, Walker, Graeme, Hitchin, James R, Milbradt, Alexander G, Orts, Julien

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib von James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J

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The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells von Harris, William J., Huang, Xu, Lynch, James T., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Ogilvie, Donald J., Somervaille, Tim C.P.

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CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1 von Lynch, James T., Cockerill, Mark J., Hitchin, James R., Wiseman, Daniel H., Somervaille, Tim C.P.

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Discovery of potent inhibitors of the lysophospholipase autotaxin von Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish

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Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase von Hamilton, Niall M, Dawson, Martin, Fairweather, Emma E, Hamilton, Nicola S, Hitchin, James R, James, Dominic I, Jones, Stuart D, Jordan, Allan M, Lyons, Amanda J, Small, Helen F, Thomson, Graeme J, Waddell, Ian D, Ogilvie, Donald J

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure von Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments von Hitchin, James R., Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma E., Hutton, Colin, Jordan, Allan M., McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J., Waddell, Ian, Ogilvie, Donald J.

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Discovery of potent inhibitors of the lyso phospholipase autotaxin von Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish

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Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate, Mcgonagle, Alison, Jordan, Allan, Acton, Ben, Fairweather, Emma, Griffiths, Louise, Hamilton, Niall M, Hamilton, Nicola, Hitchin, James R, Hutton, Colin, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel, Small, Helen F, Stowell, Alexandra, Tucker, Julie, Waddell, Ian, Ogilvie, Donald J

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A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones von Hitchin, James R., Hamilton, Niall M., Jordan, Allan M., Lyons, Amanda J., Ogilvie, Donald J.

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Discovery of potent inhibitors of the lysophospholipase autotaxin von Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, T, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M, Hitchin, James R, Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H, Ryder, Hamish

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Abstract 1139: Novel, cellular active inhibitors of G6PD, a key mediator of ROS-induced cellular stress von Jordan, Allan M., Hamilton, Niall M., Hamilton, Nicola S., Hitchin, James R., James, Dominic I., Jones, Stuart D., Lyons, Amanda J., March, H. Nikki, Thomson, Graeme J., Waddell, Ian D., Ogilvie, Donald J.

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h von Hitchin, James R, Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J, Fairweather, Emma E, Hutton, Colin, Jordan, Allan M, McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J, Waddell, Ian, Ogilvie, Donald J

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