Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer von Kitai, Hidenori, Ebi, Hiromichi, Tomida, Shuta, Floros, Konstantinos V, Kotani, Hiroshi, Adachi, Yuta, Oizumi, Satoshi, Nishimura, Masaharu, Faber, Anthony C, Yano, Seiji

Volltext

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1 von Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C., Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Pelle, Patricia Della, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H., Engelman, Jeffrey A.

Volltext

4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells von Roselli, Emiliano, Boucher, Justin C, Li, Gongbo, Kotani, Hiroshi, Spitler, Kristen, Reid, Kayla, Cervantes, Estelle V, Bulliard, Yannick, Tu, Nhan, Lee, Sae Bom, Yu, Bin, Locke, Frederick L, Davila, Marco L

Volltext

Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1‐rearranged tumor cells von Suzuki, Chiaki, Nishiyama, Akihiro, Arai, Sachiko, Tange, Shoichiro, Tajima, Atsushi, Tanimoto, Azusa, Fukuda, Koji, Takumi, Yohei, Kotani, Hiroshi, Takeuchi, Shinji, Yanagimura, Naohiro, Ohtsubo, Koushiro, Yamamoto, Norio, Omori, Koichi, Yano, Seiji

Volltext

Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer von Adachi, Yuta, Watanabe, Kazuyoshi, Kita, Kenji, Kitai, Hidenori, Kotani, Hiroshi, Sato, Yuki, Inase, Naohiko, Yano, Seiji, Ebi, Hiromichi

Volltext

Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage von Kotani, Hiroshi, Oshima, Hiroko, Boucher, Justin C, Yamano, Tomoyoshi, Sakaguchi, Hiroyuki, Sato, Shigeki, Fukuda, Koji, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Takeuchi, Shinji, Nishiuchi, Takumi, Oshima, Masanobu, Davila, Marco L, Yano, Seiji

Volltext

Effectiveness of Additional Immunosuppressive Drugs for Corticosteroid-refractory Immune Checkpoint Inhibitor-induced Myocarditis: Two Case Reports von Sakaguchi, Hiroyuki, Nanjo, Shigeki, Sato, Shigeki, Kotani, Hiroshi, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Suzuki, Chiaki, Shimojima, Masaya, Yano, Seiji, Takeuchi, Shinji

Volltext

Challenges in the treatment of BRAF K601E-mutated lung carcinoma: a case report of rapid response and resistance to dabrafenib and trametinib von Nishiyama, Akihiro, Sato, Shigeki, Sakaguchi, Hiroyuki, Kotani, Hiroshi, Yamashita, Kaname, Ohtsubo, Koushiro, Nanjo, Shigeki, Yano, Seiji, Mizuguchi, Keishi, Ikeda, Hiroko, Takeuchi, Shinji

Volltext

Case report: Navigating treatment pathways for cardiac intimal sarcoma with PDGFRβ N666K mutation von Nishiyama, Akihiro, Sato, Shigeki, Sakaguchi, Hiroyuki, Kotani, Hiroshi, Yamashita, Kaname, Ohtsubo, Koushiro, Mizuguchi, Keishi, Ikeda, Hiroko, Iino, Kenji, Takemura, Hirofumi, Takeuchi, Shinji

Volltext

Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers von Kotani, Hiroshi, Yamano, Tomoyoshi, Boucher, Justin C, Sato, Shigeki, Sakaguchi, Hiroyuki, Fukuda, Koji, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Takeuchi, Shinji, Nishiuchi, Takumi, Oshima, Hiroko, Oshima, Masanobu, Davila, Marco L, Yano, Seiji

Volltext

Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report von Tanimoto, Azusa, Takeuchi, Shinji, Kotani, Hiroshi, Yamashita, Kaname, Yamada, Tadaaki, Ohtsubo, Koushiro, Ebi, Hiromichi, Ikeda, Hiroko, Yano, Seiji

Volltext

Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma von Kawakami, Naoki, Namkoong, Ho, Shimoda, Masayuki, Kotani, Hiroshi, Fujiwara, Hiroshi, Hasegawa, Naoki

Volltext

C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins von Hirano, Mitsuru, Takada, Yoshinori, Wong, Chee Fah, Yamaguchi, Kazuma, Kotani, Hiroshi, Kurokawa, Tatsuki, Mori, Masayuki X., Snutch, Terrance P., Ronjat, Michel, De Waard, Michel, Mori, Yasuo

Volltext

IL-6 and G-CSF production resulting from lung cancer in an HIV patient von Kawakami, Naoki, Namkoong, Ho, Masaki, Katsunori, Kurebayashi, Yutaka, Shimoda, Masayuki, Kotani, Hiroshi, Fujiwara, Hiroshi, Hasegawa, Naoki

Volltext

105 4–1BB and optimized CD28 co-stimulation enhances function of human mono- and bi-specific third-generation CAR T cells von Roselli, Emiliano, Boucher, Justin, Li, Gongbo, Kotani, Hiroshi, Spitler, Kristen, Reid, Kayla, Bulliard, Yannick, Tu, Nhan, Lee, Sae Bom, Yu, Bin, Locke, Frederick, Davila, Marco

Volltext

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis von Masamune, Atsushi, Kotani, Hiroshi, Sörgel, Franziska Lena, Chen, Jian-Min, Hamada, Shin, Sakaguchi, Reiko, Masson, Emmanuelle, Nakano, Eriko, Kakuta, Yoichi, Niihori, Tetsuya, Funayama, Ryo, Shirota, Matsuyuki, Hirano, Tatsuya, Kawamoto, Tetsuya, Hosokoshi, Atsuki, Kume, Kiyoshi, Unger, Lara, Ewers, Maren, Laumen, Helmut, Bugert, Peter, Mori, Masayuki X., Tsvilovskyy, Volodymyr, Weißgerber, Petra, Kriebs, Ulrich, Fecher-Trost, Claudia, Freichel, Marc, Diakopoulos, Kalliope N., Berninger, Alexandra, Lesina, Marina, Ishii, Kentaro, Itoi, Takao, Ikeura, Tsukasa, Okazaki, Kazuichi, Kaune, Tom, Rosendahl, Jonas, Nagasaki, Masao, Uezono, Yasuhito, Algül, Hana, Nakayama, Keiko, Matsubara, Yoichi, Aoki, Yoko, Férec, Claude, Mori, Yasuo, Witt, Heiko, Shimosegawa, Tooru

Volltext

Haemophagocytic lymphohistiocytosis has variable time to onset following CD19 chimeric antigen receptor T cell therapy von Hashmi, Hamza, Bachmeier, Christina, Chavez, Julio C., Song, Jinming, Hussaini, Mohammad, Krivenko, Gabriel, Nishihori, Taiga, Kotani, Hiroshi, Davila, Marco L., Locke, Frederick L., Jain, Michael D.

Volltext

Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma Treated with Axicabtagene Ciloleucel von Faramand, Rawan, Jain, Michael, Staedtke, Verena, Kotani, Hiroshi, Bai, Renyuan, Reid, Kayla, Lee, Sae Bom, Spitler, Kristen, Wang, Xuefeng, Cao, Biwei, Pinilla, Javier, Lazaryan, Aleksander, Khimani, Farhad, Shah, Bijal, Chavez, Julio C., Nishihori, Taiga, Mishra, Asmita, Mullinax, John, Gonzalez, Ricardo, Hussaini, Mohammad, Dam, Marian, Brandjes, Brigett D., Bachmeier, Christina A., Anasetti, Claudio, Locke, Frederick L., Davila, Marco L.

Volltext

A Novel IL2Rα-/- Model for CAR-T Toxicity in Acute Lymphoblastic Leukemia Recapitulates Cytokine Release Syndrome and Neutropenia von Goala, Payal, Kotani, Hiroshi, Yongliang, Zhang, Reid, Kayla M., Boucher, Justin C., Savid-Frontera, Constanza, Lee, Sae Bom, Beatty, Nolan, Jain, Michael D., Davila, Marco L.

Volltext

Abstract 749: Both amplification and protein expression are required to predict FGFR tyrosine kinase inhibitor sensitivity in lung cancer von Ebi, Hiromichi, Kotani, Hiroshi, Yano, Seiji

Volltext