Topoisomerases as anticancer targets von Delgado, Justine L, Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi

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DNA Topoisomerases as Targets for Antibacterial Agents von Hiasa, Hiroshi

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Analysis of mutational patterns in quinolone resistance-determining regions of GyrA and ParC of clinical isolates von Ostrer, Lev, Khodursky, Rachel F., Johnson, James R., Hiasa, Hiroshi, Khodursky, Arkady

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Synthesis and cancer cell cytotoxicity of substituted xanthenes von Giri, Rajan, Goodell, John R., Xing, Chenguo, Benoit, Adam, Kaur, Harneet, Hiasa, Hiroshi, Ferguson, David M.

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DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities von Levine, Cindy, Hiasa, Hiroshi, Marians, Kenneth J.

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In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus von OPPEGARD, Lisa M, HAMANN, Bree L, STRECK, Kathryn R, ELLIS, Keith C, FIEDLER, Hans-Peter, KHODURSKY, Arkady B, HIASA, Hiroshi

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Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones von Oppegard, Lisa M, Streck, Kathryn R, Rosen, Jonathan D, Schwanz, Heidi A, Drlica, Karl, Kerns, Robert J, Hiasa, Hiroshi

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Determination of the Primary Target of a Quinolone Drug and the Effect of Quinolone Resistance-Conferring Mutations by Measuring Quinolone Sensitivity Based on Its Mode of Action von PFEIFFER, Emily S, HIASA, Hiroshi

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Analysis of pleiotropic transcriptional profiles: a case study of DNA gyrase inhibition von Jeong, Kyeong Soo, Xie, Yang, Hiasa, Hiroshi, Khodursky, Arkady B

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Replacement of ParC α4 Helix with That of GyrA Increases the Stability and Cytotoxicity of Topoisomerase IV-Quinolone-DNA Ternary Complexes von Pfeiffer, Emily S, Hiasa, Hiroshi

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DNA Gyrase-mediated Wrapping of the DNA Strand Is Required for the Replication Fork Arrest by the DNA Gyrase-Quinolone-DNA Ternary Complex von Hiasa, Hiroshi, Shea, Molly E.

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DNA Strand Cleavage Is Required for Replication Fork Arrest by a Frozen Topoisomerase-Quinolone-DNA Ternary Complex von Hiasa, H, Yousef, D O, Marians, K J

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding von Mustaev, Arkady, Malik, Muhammad, Zhao, Xilin, Kurepina, Natalia, Luan, Gan, Oppegard, Lisa M, Hiasa, Hiroshi, Marks, Kevin R, Kerns, Robert J, Berger, James M, Drlica, Karl

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Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acyli... von Fan, Bing-Zhi, Hiasa, Hiroshi, Lv, Wei, Brody, Scott, Yang, Zhao-Yong, Aldrich, Courtney, Cushman, Mark, Liang, Jian-Hua

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Interactions between DNA Helicases and Frozen Topoisomerase IV-Quinolone-DNA Ternary Complexes von Shea, M E, Hiasa, H

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Distinct Effects of the UvrD Helicase on Topoisomerase- Quinolone-DNA Ternary Complexes von Shea, Molly E., Hiasa, Hiroshi

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Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site von Oppegard, Lisa M., Schwanz, Heidi A., Towle, Tyrell R., Kerns, Robert J., Hiasa, Hiroshi

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Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity von Goodell, John R., Madhok, Avni A., Hiasa, Hiroshi, Ferguson, David M.

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Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase von Towle, Tyrell R., Kulkarni, Chaitanya A., Oppegard, Lisa M., Williams, Bridget P., Picha, Taylor A., Hiasa, Hiroshi, Kerns, Robert J.

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Initiation of Bidirectional Replication at the Chromosomal Origin Is Directed by the Interaction between Helicase and Primase von Hiasa, Hiroshi, Marians, Kenneth J.

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